PT103650B - COMPOSITIONS OF VEGETABLE EXTRACTS - Google Patents
COMPOSITIONS OF VEGETABLE EXTRACTS Download PDFInfo
- Publication number
- PT103650B PT103650B PT10365007A PT10365007A PT103650B PT 103650 B PT103650 B PT 103650B PT 10365007 A PT10365007 A PT 10365007A PT 10365007 A PT10365007 A PT 10365007A PT 103650 B PT103650 B PT 103650B
- Authority
- PT
- Portugal
- Prior art keywords
- extracts
- composition according
- tamarindus indica
- camellia sinensis
- malpighia glabra
- Prior art date
Links
- 239000000284 extract Substances 0.000 title claims abstract description 101
- 239000000203 mixture Substances 0.000 title claims abstract description 71
- 235000013311 vegetables Nutrition 0.000 title abstract description 3
- 240000003394 Malpighia glabra Species 0.000 claims abstract description 40
- 235000014837 Malpighia glabra Nutrition 0.000 claims abstract description 40
- 240000004584 Tamarindus indica Species 0.000 claims abstract description 35
- 235000004298 Tamarindus indica Nutrition 0.000 claims abstract description 35
- 235000006468 Thea sinensis Nutrition 0.000 claims abstract description 24
- 235000007119 Ananas comosus Nutrition 0.000 claims abstract description 20
- 235000011922 Passiflora incarnata Nutrition 0.000 claims abstract description 14
- 241001034349 Cordia ecalyculata Species 0.000 claims abstract description 13
- 240000008440 Passiflora incarnata Species 0.000 claims abstract description 13
- 241000912433 Paulinia Species 0.000 claims abstract description 13
- 241000195950 Equisetum arvense Species 0.000 claims abstract description 10
- 239000005768 Equisetum arvense L. Substances 0.000 claims abstract description 10
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 8
- 244000188472 Ilex paraguariensis Species 0.000 claims description 23
- 235000003368 Ilex paraguariensis Nutrition 0.000 claims description 23
- 241000234671 Ananas Species 0.000 claims description 17
- 239000000419 plant extract Substances 0.000 claims description 13
- 230000004580 weight loss Effects 0.000 claims description 12
- 239000002552 dosage form Substances 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 7
- 241001325266 Cordia Species 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 244000052707 Camellia sinensis Species 0.000 claims 13
- 244000269722 Thea sinensis Species 0.000 abstract description 19
- 244000099147 Ananas comosus Species 0.000 abstract description 3
- 235000003325 Ilex Nutrition 0.000 abstract 1
- 241000209035 Ilex Species 0.000 abstract 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 20
- 241000196324 Embryophyta Species 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 description 10
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 229960001948 caffeine Drugs 0.000 description 10
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 10
- 239000007903 gelatin capsule Substances 0.000 description 10
- 239000001648 tannin Substances 0.000 description 9
- 235000018553 tannin Nutrition 0.000 description 9
- 229920001864 tannin Polymers 0.000 description 9
- 206010033307 Overweight Diseases 0.000 description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 description 7
- 235000013824 polyphenols Nutrition 0.000 description 7
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 7
- 241000195955 Equisetum hyemale Species 0.000 description 6
- 239000003925 fat Substances 0.000 description 6
- 241000411851 herbal medicine Species 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 235000013616 tea Nutrition 0.000 description 6
- 240000003444 Paullinia cupana Species 0.000 description 5
- 235000000556 Paullinia cupana Nutrition 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 239000008119 colloidal silica Substances 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 108010004032 Bromelains Proteins 0.000 description 4
- 208000035484 Cellulite Diseases 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 235000000370 Passiflora edulis Nutrition 0.000 description 4
- 206010049752 Peau d'orange Diseases 0.000 description 4
- 239000004365 Protease Substances 0.000 description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- JMFSHKGXVSAJFY-UHFFFAOYSA-N Saponaretin Natural products OCC(O)C1OC(Oc2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)cc4)C(O)C1O JMFSHKGXVSAJFY-UHFFFAOYSA-N 0.000 description 4
- MOZJVOCOKZLBQB-UHFFFAOYSA-N Vitexin Natural products OCC1OC(Oc2c(O)c(O)cc3C(=O)C=C(Oc23)c4ccc(O)cc4)C(O)C(O)C1O MOZJVOCOKZLBQB-UHFFFAOYSA-N 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 235000019835 bromelain Nutrition 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000009569 green tea Nutrition 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- SGEWCQFRYRRZDC-VPRICQMDSA-N vitexin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O SGEWCQFRYRRZDC-VPRICQMDSA-N 0.000 description 4
- PZKISQRTNNHUGF-UHFFFAOYSA-N vitexine Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O PZKISQRTNNHUGF-UHFFFAOYSA-N 0.000 description 4
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 241000218996 Passiflora Species 0.000 description 3
- 235000011925 Passiflora alata Nutrition 0.000 description 3
- 235000013750 Passiflora mixta Nutrition 0.000 description 3
- 235000013731 Passiflora van volxemii Nutrition 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000019577 caloric intake Nutrition 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000001882 diuretic effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- -1 tannins) Chemical class 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 229960004559 theobromine Drugs 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- NUCLJNSWZCHRKL-UHFFFAOYSA-N allantoic acid Chemical compound NC(=O)NC(C(O)=O)NC(N)=O NUCLJNSWZCHRKL-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000002830 appetite depressant Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000036232 cellulite Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229940094952 green tea extract Drugs 0.000 description 2
- 235000020688 green tea extract Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 230000037356 lipid metabolism Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000003880 negative regulation of appetite Effects 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 229940001884 passion flower extract Drugs 0.000 description 2
- 235000020689 passion flower extract Nutrition 0.000 description 2
- 235000020733 paullinia cupana extract Nutrition 0.000 description 2
- 229940013712 pineapple extract Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- 239000007909 solid dosage form Substances 0.000 description 2
- 230000009044 synergistic interaction Effects 0.000 description 2
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 2
- 229940062013 tamarind extract Drugs 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 244000085625 Equisetum Species 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 244000288157 Passiflora edulis Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 235000011449 Rosa Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000008649 adaptation response Effects 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000019787 caloric expenditure Nutrition 0.000 description 1
- 235000021236 calorie-restricted diet Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000021045 dietary change Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940126707 lipid peroxidation inhibitor Drugs 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 230000002366 lipolytic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000012245 magnesium oxide Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000009329 organic farming Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000000395 remineralizing effect Effects 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035924 thermogenesis Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
SÃO DIVULGADAS COMPOSIÇÕES COMPREENDENDO EXTRACTOS VEGETAIS SELECCIONADOS DO GRUPO COMPREENDENDO DE MALPIGHIA GLABRA (L.), CAMELLIA SINENSIS ( L.), ILEX PARAGURIENSIS (S.H), TAMARINDUS INDICA (L:), ANANAS COMOSUS (L:), PAULINIA CUPANA ( H.B.K.), CORDIA ECALYCULATA ( V. ), EQUISETUM ARVENSE (L.) E PASSIFLORA INCARNATA (L.). AS REFERIDAS COMPOSIÇÕES PODEM SER UTILIZADAS COMO SUPLEMENTOS ALIMENTARES EM REGIMES DE EMAGRECIMENTO.COMPOSITIONS ARE DISCLOSED UNDERSTANDING SELECTED VEGETABLE EXTRACTS OF THE GROUP UNDERSTANDING MALPIGHIA GLABRA (L.), CAMELLIA SINENSIS (L.), ILEX PARAGURIENSIS (SH), TAMARINDUS INDICA (L :), ANANAS COMOSUS (L :), PAULINIA CUPANA (HBK) , CORDIA ECALYCULATA (V.), EQUISETUM ARVENSE (L.) AND PASSIFLORA INCARNATA (L.). Said compositions may be used as food supplements in regimens for deagriculture.
Description
A presente invenção refere-se a composições compreendendo extractos vegetais seleccionados do grupo compreendendoThe present invention relates to compositions comprising plant extracts selected from the group comprising
Malpighia glabra (L.),Malpighia glabra (L.),
Camellia sinensis (L.),Camellia sinensis (L.),
Ilex paraguariensis (S.H.) , Tamarindus indica (L.),Ilex paraguariensis (S.H.), Tamarindus indica (L.),
Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.),Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.),
Equisetum arvense (L.) e Passiflora incarnata (L.). As composições da presente invenção podem ser utilizadas como suplementos alimentares em regimes de emagrecimento.Equisetum arvense (L.) and Passiflora incarnata (L.). The compositions of the present invention may be used as dietary supplements in weight loss regimens.
ANTECEDENTES DA INVENÇÃO papel dos extractos vegetais é principalmente considerado como adjuvante de acção terapêutica ou simplesmente como complementos alimentares. Desde a antiguidade que se utilizam empiricamente extractos vegetais no tratamento de doenças. Apesar dos grandes desenvolvimentos da farmacologia ocidental, nomeadamente com o isolamento de princípios activos e a síntese química de novas moléculas com propriedades farmacológicas, a fitoterapia tem vindo a ganhar importância no mundo ocidental, nomeadamente por se terem verificado benefícios em determinadas patologias (ver revisão sobre fitoterapia em Cunha, A.P., Silva,BACKGROUND OF THE INVENTION The role of plant extracts is primarily considered as an adjuvant to therapeutic action or simply as food supplements. From ancient times plant extracts are used empirically in the treatment of diseases. Despite major developments in western pharmacology, notably with the isolation of active ingredients and the chemical synthesis of new molecules with pharmacological properties, herbal medicine has gained in importance in the western world, notably because there have been benefits in certain pathologies (see review on herbal medicine in Cunha, AP, Silva,
A.P. e Roque, O.R. (2003) Plantas e produtos vegetais em fitoterapia, Fundação Calouste Gulbenkian, Lisboa).A.P. and Roque, O.R. (2003) Plants and plant products in herbal medicine, Calouste Gulbenkian Foundation, Lisbon).
A acerola, Malpighia glabra (L.), tem origem nas Antilhas, América Central e norte da América do Sul. O fruto nasce na aceroleira que é um arbusto de até 3 m de altura, e possui vitaminas A, Bl, B2, B3, cálcio, fósforo, ferro e principalmente vitamina C, que em algumas variedades, chega a ser de até 5 gramas por 100 gramas de polpa. Este valor chega a ser cem vezes superior ao da laranja ou limão (Malpighia glabra. (2006, Junho 10). Wikipédia, a enciclopédia livre. Obtido às 16:07, Janeiro 23, 2007 de http://pt.wikipedia.Org/w/index.php7title =Malpighia_glabra&oldid=2280627) . Sendo um fonte natural rica em ácido ascórbico (vitamina C) , carotenóides e antocianinas, um extracto deste fruto tem importantes propriedades antioxidantes, antiasténicas e é um bom regenerador celular.The acerola, Malpighia glabra (L.), originates from the Antilles, Central America and northern South America. The fruit is born in the acerola tree, which is up to 3 m high, and has vitamins A, Bl, B2, B3. , calcium, phosphorus, iron and especially vitamin C, which in some varieties is up to 5 grams per 100 grams of pulp. This is up to 100 times higher than orange or lemon (Malpighia glabra. (2006, June 10). Wikipedia, the free encyclopedia. Retrieved at 16:07, January 23, 2007 from http://en.wikipedia.Org /w/index.php7title = Malpighia_glabra & oldid = 2280627). Being a natural source rich in ascorbic acid (vitamin C), carotenoids and anthocyanins, an extract of this fruit has important antioxidant, antiasthenic properties and is a good cellular regenerator.
O chá-verde, Camellia sinensis (L.)r é um arbusto ou pequena árvore, originário da Ásia, particularmente das florestas daGreen tea, Camellia sinensis (L.) r is a shrub or small tree originating in Asia, particularly from the forests of
Birmânia ao Vietname e da China Meridional. Dos das suas folhas destacam-se principalmente constituintes as xantinas (representadas principalmente por cafeína) e polifenóis. A cafeína proporciona uma acção estimulante sobre o sistema nervoso central, reduzindo a fadiga e inibindo o sono. Os polifenóis mostraram ser inibidores da peroxidação lipídica e captadores de radicais livres (propriedades antioxidantes) . Os flavonóides (polifenóis antioxidantes) têm uma acção lipolítica, por potenciação das catecolaminas, favorecendo o metabolismo natural das gorduras. Tem sido também utilizado como coadjuvante em regimes de emagrecimento (Cunha et al., 2003).Burma to Vietnam and South China. Of its leaves, the main constituents are xanthines (mainly caffeine) and polyphenols. Caffeine provides a stimulating action on the central nervous system, reducing fatigue and inhibiting sleep. Polyphenols have been shown to be lipid peroxidation inhibitors and free radical scavengers (antioxidant properties). Flavonoids (antioxidant polyphenols) have a lipolytic action by potentiation of catecholamines, favoring the natural metabolism of fats. It has also been used as an adjunct in weight loss regimens (Cunha et al., 2003).
mate, Ilex paraguariensis (S.H.), é uma árvore ou arbusto espontâneo no norte da Argentina, Paraguai, Uruguai e sul do Brasil. Dos constituintes das suas folhas destacam-se basicamente as xantinas (representadas principalmente por cafeína e teobromina), polifenóis (incluindo taninos), vitaminas e sais minerais. Os taninos têm acção drenante, liporredutora e tonificante. Os extractos desta planta retardam a progressão do bolo alimentar, e permitem o prolongamento da sensação de saciedade. Tem sido utilizado no tratamento da neurastenia, sendo também diurético e bom coadjuvante no tratamento da obesidade (Cunha et al., 2003).mate, Ilex paraguariensis (S.H.), is a spontaneous tree or shrub in northern Argentina, Paraguay, Uruguay, and southern Brazil. The constituents of its leaves are mainly xanthines (represented mainly by caffeine and theobromine), polyphenols (including tannins), vitamins and minerals. Tannins have draining, lipid-reducing and toning action. The extracts of this plant slow the progression of the bolus, and allow the prolongation of the feeling of satiety. It has been used in the treatment of neurasthenia, being also a diuretic and a good adjunct in the treatment of obesity (Cunha et al., 2003).
O tamarindo, Tamarindus indica (L.), é nativo da índia e Sudeste asiático e cresce perto de regiões tropicais e subtropicais do sub-continente indiano. Este fruto contém pectinas, açúcares simples, ácidos orgânicos (incluindo o ácido tartárico) e sais. A polpa é um laxante suave recomendado na obstipação crónica e/ou resultante da mudança de regime alimentar e tem uma acção anti-inflamatória intestinal.Tamarind, Tamarindus indica (L.), is native to India and Southeast Asia and grows near tropical and subtropical regions of the Indian subcontinent. This fruit contains pectins, simple sugars, organic acids (including tartaric acid) and salts. Pulp is a mild laxative recommended in chronic constipation and / or resulting from dietary change and has an intestinal anti-inflammatory action.
O ananás, Ananas comosus (L.), é o fruto de uma planta nativa da América tropical. Este contém principalmente fibras e enzimas proteoliticas, incluindo a bromelaína. A acção anti-inflamatória da bromelaína permite a fragmentação parcial das fibras proteicas que envolvem o tecido celulítico, favorecendo a mobilização dos depósitos gordos das camadas adiposas - acção drenante. É utilizado como coadjuvante no tratamento da celulite (Cunha et al., 2003).Pineapple, Ananas comosus (L.), is the fruit of a plant native to tropical America. It mainly contains proteolytic fibers and enzymes, including bromelain. The anti-inflammatory action of bromelain allows partial fragmentation of the protein fibers surrounding the cellulitic tissue, favoring the mobilization of fat deposits from the fat layers - draining action. It is used as an adjunct in the treatment of cellulite (Cunha et al., 2003).
O guaraná, Paulinia cupana (H.B.K.), é a semente de um arbusto trepador nativo do Brasil e Uruguai. Contém cafeína, taninos catéquicos, vestígios de teofilina e teobromina. É um estimulante do sistema nervoso central, energizante e permite um aumento do dispêndio calórico. Combate a fadiga psíquica e física que acompanham o excesso de peso e/ou a prática de um regime alimentar com restrições calóricas. Diminui o apetite e é utilizado como coadjuvante no tratamento do excesso de peso (Cunha et al.r 2003). Verificou-se recentemente que uma dieta suplementada com guaraná tem efeitos no metabolismo dos lípidos (Lima, W.P., Carnevali Jr., L.C., Eder, R., Rosa, L.F.B.P.C., Bacchi, E.M. e Seelaender, M.C.L. (2005) Lipid metabolism in Trained rats: Effect of guarana (Paulinia cupana Mart.) supplementation, Clinicai Nutrition, 24, 1019-1028). É muito utilizado por desportistas para melhorar o desempenho físico.Guarana, Paulinia cupana (HBK), is the seed of a climbing bush native to Brazil and Uruguay. Contains caffeine, catechic tannins, traces of theophylline and theobromine. It is an energizing central nervous system stimulant and allows an increase in caloric expenditure. Combat the psychic and physical fatigue that accompany overweight and / or the practice of a calorie-restricted diet. Decreases appetite and is used as an adjunct in the treatment of overweight (Cunha et al. R 2003). A diet supplemented with guarana has recently been found to have effects on lipid metabolism (Lima, WP, Carnevali Jr., LC, Eder, R., Rosa, LFBPC, Bacchi, EM and Seelaender, MCL (2005). Lipid metabolism in Trained rats: Effect of guarana (Paulinia cupana Mart.) supplementation, Clinical Nutrition, 24, 1019-1028). It is widely used by sportsmen to improve physical performance.
O chá-de-Bugre, Cordia ecalyculata (V.), é preparado a partir de folhas de uma pequena árvore originária da América do Sul. Este chá contém polifenóis (incluindo taninos), potássio, alantoína e ácido alantóico. É conhecido como supressor do apetite, diurético e eficaz na redução de gorduras localizadas (Taylor, T. (2005) The healing power of rainforest. A guide to understanding and using herbal medicinais herbs, Square One Publishers, NY).Bugre tea, Cordia ecalyculata (V.), is made from leaves of a small tree originating in South America. This tea contains polyphenols (including tannins), potassium, allantoin and allantoic acid. It is known as appetite suppressant, diuretic and effective in reducing localized fat (Taylor, T. (2005) The healing power of rainforest. A guide to understanding and using herbal medicinal herbs, Square One Publishers, NY).
A cavalinha, Equisetum arvense (L.), é uma planta herbácea vivaz nativa da Europa, Norte de África, Sul da Ásia e América em solos argilo-siliciosos, húmidos e sombrios. Existe em quase todo o território de Portugal. É rica em sais minerais, flavonóides e taninos, sendo a quercetina o constituinte activo. Os flavonóides conferem uma acção diurética, evitando a formação de cálculos renais e biliares. A cavalinha é recomendada quando se pretenda aumentar a diurese, como veículo da redução da retenção de líquidos, particularmente no caso da obesidade acompanhada de retenção de líquidos. Tem também uma acção remineralizante (Cunha et ai., 2003).The horsetail, Equisetum arvense (L.), is a perennial herbaceous plant native to Europe, North Africa, South Asia, and America on damp, damp and silty clay soil. It exists in almost all of Portugal. It is rich in mineral salts, flavonoids and tannins, being quercetin the active constituent. Flavonoids confer a diuretic action, preventing the formation of kidney and gallstones. Horsetail is recommended when diuresis is to be increased as a vehicle for reducing fluid retention, particularly in the case of obesity accompanied by fluid retention. It also has a remineralizing action (Cunha et al., 2003).
A passiflora, Passíflora incarnata (L.), também conhecida por maracujá, é uma trepadeira arbustiva espontânea na América tropical. As suas partes aéreas têm inúmeros flavonóides entre os quais a vitexina. Tem uma acção sedativa e tranquilizante, prevenindo nomeadamente a irritabilidade em determinados regimes de emagrecimento (Cunha et al., 2003; Dhawan, K., Dhawan, S. e Sharma, A. (2004) Passiflora: a review update, Journal of Ethnopharmacology 94, 1-23).Passionflower, Passiflora incarnata (L.), also known as passion fruit, is a spontaneous shrubbery in tropical America. Its aerial parts have numerous flavonoids including vitexin. It has a sedative and soothing action, particularly preventing irritability in certain weight loss regimes (Cunha et al., 2003; Dhawan, K., Dhawan, S. and Sharma, A. (2004) Passiflora: a review update, Journal of Ethnopharmacology 94, 1-23).
Estas e outras plantas e respectivos extractos são tradicionalmente utilizados separadamente. Os complementos fitoterapêuticos são principalmente compostos de uma só planta na forma, por exemplo, de pó. A combinação de vários extractos de plantas permite não só a acção individual de cada extracto, como o estabelecimento de sinergias que reforçam e potencializam a acção das plantas (ver revisão por Williamson, E.M. (2001) Synergy and other interactions in phytomedicines, Phytomedicine, 8(5), 401-409). Estas interacções sinérgicas são fundamentais na fitoterapia pois permitem explicar as frequentes dificuldades no isolamento de um único principio activo, e também explicam a eficácia de doses aparentemente baixas de constituintes activos num produto fitoterapêutico. As interacções sinérgicas estão não só documentadas para constituintes num extracto total de uma única planta, como também entre diferentes plantas numa formulação. Williamson (2001) descreve vários exemplos de sinergia entre diferentes plantas numa formulação, referindo que a avaliação destes efeitos sinérgicos é naturalmente complicada. É o caso de formulações, por exemplo na medicina Chinesa, que consistem por vezes em sete ou mais extractos vegetais, na maioria dos casos sem caracterização dos extractos e dos processos de extracção, com plantas provenientes de crescimento espontâneo e sob condições não controladas.These and other plants and their extracts are traditionally used separately. Phytotherapeutic supplements are mainly composed of a single plant in the form of, for example, powder. The combination of various plant extracts allows not only the individual action of each extract, but also the establishment of synergies that enhance and potentiate plant action (see review by Williamson, EM (2001). Synergy and other interactions in phytomedicines, Phytomedicine, 8 (5), 401-409). These synergistic interactions are fundamental in herbal medicine as they explain the frequent difficulties in isolating a single active ingredient, and also explain the effectiveness of apparently low doses of active constituents in a herbal product. Synergistic interactions are not only documented for constituents in a single plant total extract, but also between different plants in a formulation. Williamson (2001) describes several examples of synergy between different plants in a formulation, noting that the evaluation of these synergistic effects is naturally complicated. This is the case for formulations, for example in Chinese medicine, which sometimes consist of seven or more plant extracts, in most cases without characterization of the extracts and extraction processes, with plants coming from spontaneous growth and under uncontrolled conditions.
É, portanto, necessário que as composições de fitoterapia se baseiem em parâmetros de qualidade, reprodutibilidade segurançaIt is therefore necessary for herbal medicine compositions to be based on quality, reproducibility and safety parameters.
Extraction methods and chemical standardization of botanicals and herbal preparations, Journal of ChromatographyExtraction methods and chemical standardization of botanicals and herbal preparations, Journal of Chromatography
B,B,
812,812,
23-33) . Além disso, é igualmente desejável que do ponto de vista do consumidor, a administração seja cómoda, isto é, fácil, rápida, indolor e que o extracto não necessite, por exemplo, de manipulações adicionais.23-33). In addition, it is also desirable that from the consumer's point of view administration is convenient, that is, easy, quick, painless and that the extract does not require, for example, further manipulation.
emagrecimento é muito difícil para alguns indivíduos. 0 ganho de peso resulta quando a ingestão calórica num indivíduo excede o número de calorias gastas como energia. Numa tentativa de perder peso, os indivíduos pretendem frequentemente atingir um déficit calórico (i. e., diminuindo a ingestão calórica de modo que as calorias gastas como energia excedam a ingestão calórica). Geralmente, isto resulta numa resposta adaptativa de diminuição da taxa metabólica basal e perda de músculo esquelético, o que pode tornar ainda mais difícil a manutenção do peso (assim que o peso desejado for atingido). É pois desejável que um programa de emagrecimento inclua complementos alimentares que auxiliem o organismo na manutenção do seu equilíbrio energético e ao mesmo tempo estimulem ou induzam processos indirectos de perda de peso, tais como lipólise, supressão do apetite, diurese, termogénese, etc. Alguns extractos vegetais já incluem algumas destas propriedades. No entanto a combinação de vários extractos (3, 4, 5, 6 ou mais) permitirá não só uma abordagem multifacetada da perda de peso como quantidades mais baixas desses mesmos extractos. Esta abordagem é particularmente desejada para indivíduos que não podem ou preferem não utilizar fármacos e, que no caso de indivíduos obesos, esses fármacos podem ser contra-indicados devido ao risco de potenciais efeitos colaterais prejudiciais.Weight loss is very difficult for some individuals. Weight gain results when an individual's caloric intake exceeds the number of calories spent on energy. In an attempt to lose weight, individuals often aim to achieve a calorie deficit (i.e., by decreasing caloric intake so that calories spent on energy exceed caloric intake). This usually results in an adaptive response to decreased basal metabolic rate and skeletal muscle loss, which can make weight maintenance even more difficult (once the desired weight is reached). It is therefore desirable for a weight loss program to include dietary supplements that assist the body in maintaining its energy balance and at the same time stimulate or induce indirect weight loss processes such as lipolysis, appetite suppression, diuresis, thermogenesis, etc. Some plant extracts already include some of these properties. However, the combination of several extracts (3, 4, 5, 6 or more) will not only allow a multifaceted approach to weight loss but also lower amounts of these extracts. This approach is particularly desirable for individuals who cannot or prefer not to use drugs, and for obese individuals such drugs may be contraindicated due to the risk of potential harmful side effects.
De acordo com o exposto, existe a necessidade na técnica para um suplemento alimentar que promova a perda de peso, mantendo o equilíbrio energético e muscular, ao mesmo tempo que seja seguro e de cómoda utilização.Accordingly, there is a need in the art for a dietary supplement that promotes weight loss while maintaining energy and muscle balance while being safe and convenient to use.
SUMÁRIO DA INVENÇÃOSUMMARY OF THE INVENTION
A presente invenção refere-se a uma composição de extractos vegetais caracterizada por compreender uma combinação de, pelo menos, três extractos seleccionados do grupo compreendendo Malpighia glabra (L.)r Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equísetum arvense (L.) e Passiflora incarnata (L.) . Numa Forma de realização preferida da presente invenção, a composição é caracterizada por compreender uma combinação de quatro ou mais dos referidos extractos vegetais.The present invention relates to a composition of plant extract comprising a combination of at least three extracts selected from the group comprising Malpighia glabra (L.) r Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equísetum arvense (L.) and Passiflora incarnata (L.). In a preferred embodiment of the present invention, the composition is characterized in that it comprises a combination of four or more of said plant extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Ananas comosus (L.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 16-20%, 8-12%, 11-15%, 8-12% e 47-51%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 35, 20, 25, 20 e 95 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention, the composition is characterized by comprising extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Ananas comosus (L. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 16-20%, 8-12%, 11-15%, 8-12% and 47-51%, respectively and in a most preferred form, in a dosage form. containing about 35, 20, 25, 20 and 95 mg, respectively, of dried extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Paulinia cupana (H.B.K.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 16-20%, 13-17%, 18-22%, 18-22% e 24-28%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 35, 30, 40, 40 e 50 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention, the composition is characterized by comprising extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Paulinia cupana (HBK). , in any proportions. In a more preferred form, in a weight ratio of extracts of about 16-20%, 13-17%, 18-22%, 18-22% and 24-28%, respectively and in a most preferred form, in a dosage form. containing about 35, 30, 40, 40 and 50 mg, respectively, of dried extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Cordia ecalyculata (V.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 8-12%, 13-17%, 18-22%, 8-12% e 43-47%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 20, 30, 40, 20 e 85 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention, the composition is characterized by comprising extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Cordia ecalyculata (V. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 8-12%, 13-17%, 18-22%, 8-12% and 43-47%, respectively and in a most preferred form, in a dosage form. containing about 20, 30, 40, 20 and 85 mg, respectively, of dried extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Equisetum arvense (L.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 13-17%, 13-17%, 13-17%, 18-22% e 31-35%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 30, 30, 30, 40 e 65 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention, the composition is characterized by comprising extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Equisetum arvense (L. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 13-17%, 13-17%, 13-17%, 18-22% and 31-35%, respectively and in a most preferred form, in a dosage form. containing about 30, 30, 30, 40 and 65 mg, respectively, of dried extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Tamarindus indica (L.), Ananas comosus (L.)f Cordia ecalyculata (V.), e Passiflora incarnata (L.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 8-12%, 11-15%, 13-17%, 34-38% e 24-28%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 20, 25, 30, 70 e 50 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention is the composition comprising extracts of said Malpighia glabra (L.), Tamarindus indica (L.), Ananas comosus (L.) ecalyculata Cordia f (p), Passiflora incarnata and ( L.), in any proportions. In a more preferred form, in a weight ratio of extracts of about 8-12%, 11-15%, 13-17%, 34-38% and 24-28%, respectively and in a most preferred form, in a dosage form. containing about 20, 25, 30, 70 and 50 mg, respectively, of dried extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por ser utilizada na preparação de um suplemento alimentar para regimes de emagrecimento.In a preferred embodiment of the present invention, the composition is characterized in that it is used in the preparation of a dietary supplement for weight loss regimens.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender adicionalmente um ou mais adjuvantes e/ou veículos farmaceuticamente aceitáveis.In a preferred embodiment of the present invention, the composition is further comprising one or more pharmaceutically acceptable adjuvants and / or vehicles.
DESCRIÇÃO DETALHADA DA INVENÇÃODETAILED DESCRIPTION OF THE INVENTION
A presente invenção refere-se a composições compreendendo a mistura de, pelo menos, três extractos vegetais seleccionados do grupo compreendendo Malpighia glabra (L.), Camellia sinensis (L.)f Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equisetum arvense (L.) e Passiflora incarnata (L.). As composições da presente invenção podem ser utilizadas como suplementos alimentares em regimes de emagrecimento.The present invention relates to compositions comprising a mixture of at least three plant extracts selected from the group comprising Malpighia glabra (L.), Camellia sinensis (L.) f Ilex paraguariensis (SH), Tamarindus indica (L.) Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equisetum arvense (L.) and Passiflora incarnata (L.). The compositions of the present invention may be used as dietary supplements in weight loss regimens.
Extractos vegetaisVegetable extracts
Os extractos vegetais das composições da presente invenção são extractos secos de plantas medicinais. Estas plantas são cultivadas com técnicas de agricultura biológica. As extracções são realizadas em plantas seleccionadas e utilizando técnicas de extracção com solventes inócuos. A secagem dos extractos é realizada, de um modo preferido, por atomização. Os processos e metodologias são bem conhecidas dos especialistas na técnica e estão de acordo com certificados de qualidade reconhecidos internacionalmente. Os extractos são caracterizados com base nas caracteristicas físicas (e. g., aspecto, cor, odor/sabor, pH em solução, solubilidade, etc.) e microbiológicas (e. g.r ensaios para a presença de estirpes bacterianas patogénicas) . Além disso, é quantificado um princípio activo padronizado específico para cada extracto. No extracto de Malpighia glabra (L.) (acerola) o princípio activo quantificado é o ácido ascórbico. No extracto de Ilex paraguariensis (S.H.) (mate) os princípios activos quantificados são a cafeína e a teobromina. No extracto de Camellia sinensis (L.) (chá-verde) os princípios activos quantificados são polifenóis e EGCG (epigalhocatequina galhato) . No extracto de Tamarindus indica (L.) (tamarindo) o princípio activo quantificado é o ácido tartárico. No extracto de Ananas comosus (L.) (ananás) o princípio activo quantificado é a bromelaína. No extracto de Paulinia cupana (H.B.K.) (guaraná) os princípios activos quantificados são cafeína e taninos. No extracto de Cordia ecalyculata (V.) (chá-de-bugre) os princípios activos quantificados são taninos. No extracto de EquisetumPlant extracts of the compositions of the present invention are dried extracts of medicinal plants. These plants are grown using organic farming techniques. Extractions are performed on selected plants and using innocuous solvent extraction techniques. The extracts are preferably dried by spraying. The processes and methodologies are well known to those skilled in the art and are in accordance with internationally recognized quality certificates. The extracts are characterized based on their physical characteristics (eg, appearance, color, odor / taste, solution pH, solubility, etc.) and microbiological (eg r assays for the presence of pathogenic bacterial strains). In addition, a specific standardized active ingredient is quantified for each extract. In Malpighia glabra (L.) (acerola) extract the quantified active ingredient is ascorbic acid. In Ilex paraguariensis (SH) (mate) extract the quantified active ingredients are caffeine and theobromine. In Camellia sinensis (L.) extract (green tea) the quantified active ingredients are polyphenols and EGCG (epigallocatechin gallhato). In the extract of Tamarindus indica (L.) (tamarind) the quantified active ingredient is tartaric acid. In the extract of Ananas comosus (L.) (pineapple) the quantified active ingredient is bromelain. In Paulinia cupana (HBK) extract (guarana) the quantified active ingredients are caffeine and tannins. In Cordia ecalyculata (V.) extract (buggy tea) the quantified active ingredients are tannins. In the extract of Equisetum
Combinações de extractosExtract Combinations
A presente invenção refere-se a composições caracterizadas por compreenderem combinações de, peio menos, três extractos seleccionados do grupo compreendendo Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equisetum arvense (L.) e Passiflora incarnata (L.).The present invention relates to compositions characterized in that they comprise combinations of at least three extracts selected from the group comprising Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equisetum arvense (L.) and Passiflora incarnata (L.).
A escolha do número e tipos de extractos compreendidos nas composições baseia-se por um lado nas propriedades reconhecidas de cada extracto (como já referidas) e nas indicações especificas pretendidas para essa mesma composição. No âmbito de um programa de emagrecimento, estas indicações especificas podem ser não só individuais como sazonais e podem incluir, por exemplo, indicações anticeluliticas, antiasténicas, de supressão do apetite, etc. As quantidades de cada extracto numa determinada composição têm como referência de segurança a Dose Diária Recomendada (DDR) para cada um dos princípios activos padronizados ou extractos caracterizados. De acordo com o exposto, o conteúdo de ácido ascórbico no extracto de acerola utilizado não deverá ultrapassar 1000 mg (DDR), a quantidade de extracto de mate utilizado não deverá ultrapassar 3 g, o conteúdo de cafeína no extracto de chá-verde utilizado não deverá ultrapassar 240-320 mg, a quantidade de extracto de tamarindo utilizado não deverá ultrapassar 1-2 g, a quantidade de extracto de ananás utilizado não deverá ultrapassar 2 g, o conteúdo de cafeína no extracto de guaraná utilizado não deverá ultrapassar 100 mg, a quantidade de extracto de cavalinha utilizado não deverá ultrapassar 1-2 g e o conteúdo de vitexina no extracto de passiflora utilizado não deverá ultrapassarThe choice of the number and types of extracts comprised in the compositions is based on the one hand on the recognized properties of each extract (as already mentioned) and the specific indications desired for that same composition. Within a weight loss program, these specific indications may be both individual and seasonal and may include, for example, anti-cellulite, antiasthenic, appetite suppressant, etc. The amounts of each extract in a given composition are safety reference the Recommended Daily Intake (DDR) for each of the standard active ingredients or characterized extracts. Accordingly, the ascorbic acid content of the acerola extract used should not exceed 1000 mg (DDR), the amount of mate extract used should not exceed 3 g, the caffeine content of the green tea extract used should not exceed should not exceed 240-320 mg, the amount of tamarind extract used should not exceed 1-2 g, the amount of pineapple extract used should not exceed 2 g, the caffeine content in guarana extract used should not exceed 100 mg, the amount of horsetail extract used should not exceed 1-2 g and the vitexin content in the passionflower extract used should not exceed
100 mg.100 mg.
AdministraçãoAdministration
De acordo com o método de administração pretendido, as composições da presente invenção compreenderão tipicamente um ou mais adjuvantes e/ou veículos farmaceuticamente aceitáveis convencionais. A formulação de fármacos é discutida de um modo geral em, por exemplo, Hoover, John E. (1975) Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, PA..According to the intended method of administration, the compositions of the present invention will typically comprise one or more conventional pharmaceutically acceptable adjuvants and / or vehicles. Drug formulation is generally discussed in, for example, Hoover, John E. (1975) Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, PA.
As formas de dosagem sólidas para administração oral incluem, por exemplo, cápsulas, comprimidos, pílulas, gomas, pós e granulados. Nessas formas de dosagem sólidas, as composições dos referidos extractos são vulgarmente combinadas com um ou mais adjuvantes, e. g., lactose, sacarose, pó de amido, ésteres celulósicos de ácidos alcanóicos, ésteres alquilicos de celulose, talco, ácido esteárico, estearato de magnésio, óxido de magnésio, sais de sódio e cálcio de ácidos fosfóricos e sulfúricos, gelatina, goma de acácia, alginato de sódio, polivinilpirrolidona e/ou álcool polivinílico e, depois, comprimidas ou encapsulados para administração conveniente. Essas cápsulas ou comprimidos podem conter uma formulação deSolid dosage forms for oral administration include, for example, capsules, tablets, pills, gums, powders and granules. In such solid dosage forms, the compositions of said extracts are commonly combined with one or more adjuvants, e.g. lactose, sucrose, starch powder, cellulosic esters of alkanoic acids, alkyl esters of cellulose, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, gelatin, Acacia, sodium alginate, polyvinylpyrrolidone and / or polyvinyl alcohol and then compressed or encapsulated for convenient administration. Such capsules or tablets may contain a formulation of
ou magnésio ou carbonato ou bicarbonato de cálcio. Os comprimidos e pílulas podem ser adicionalmente preparados com revestimentos entéricos.or magnesium or calcium carbonate or bicarbonate. Tablets and pills may additionally be prepared with enteric coatings.
As formas de dosagem líquidas para administração oral incluem, por exemplo, emulsões, soluções, suspensões, xaropes e elixires farmaceuticamente aceitáveis contendo diluentes inertes utilizados habitualmente na técnica (e. g., água). Essas composições também podem compreender adjuvantes, tais como agentes de humidificação, emulsionantes, de suspensão, aromatizantes (e.g., edulcorante) e/ou de fragrância.Liquid dosage forms for oral administration include, for example, pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used in the art (e.g., water). Such compositions may also comprise adjuvants such as wetting, emulsifying, suspending, flavoring (e.g. sweetening) and / or fragrance agents.
Também podem ser utilizados outros adjuvantes e modos de administração bem conhecidos na técnica.Other adjuvants and modes of administration well known in the art may also be used.
Os seguintes exemplos pretendem ser ilustrativos e não limitativos, e representam formas de realização específicas da presente invenção.The following examples are intended to be illustrative and not limiting, and represent specific embodiments of the present invention.
EXEMPLOSEXAMPLES
Os exemplos de composições gue se seguem foram preparadas com extractos vegetais caracterizados e certificados para utilização em fitoterapêutica. Cada extracto em pó seco contém um principio activo padronizado e devidamente guantifiçado. 0The following composition examples were prepared with characterized plant extracts and certified for use in herbal medicine. Each dry powder extract contains a standard and properly guaranteed active ingredient. 0
Extracto de acerola a 26,5%, contém 28% de ácido ascórbico; o Extracto de mate contém 9% de cafeína e 0,35% de teobromina; o Extracto de chá-verde contém 28% de polifenóis e 3,79% de EGCG (epigalhocatequina galhato); o Extracto de tamarindo contém 5% de ácido tartárico; o Extracto de ananás contém 80 GDU/g de bromelaina; o Extracto de guaraná contém 10% de cafeína e 1% de taninos; o Extracto de chá-de-bugre contém 6,7% de taninos: o Extracto de cavalinha contém 2,74% de guercetina; o Extracto de passiflora contém 3,8% de vitexina. Os extractos secos são fornecidos, por exemplo, pela Anidro Brasil Extrações Ltda,26.5% acerola extract contains 28% ascorbic acid; Mate Extract contains 9% caffeine and 0.35% theobromine; Green Tea Extract contains 28% polyphenols and 3.79% EGCG (epigallocatechin gallate); Tamarind Extract contains 5% tartaric acid; Pineapple Extract contains 80 GDU / g bromelain; Guarana Extract contains 10% caffeine and 1% tannins; Bugre tea extract contains 6.7% tannins: Horsetail extract contains 2.74% guercetin; Passionflower Extract contains 3.8% vitexin. Dry extracts are provided, for example, by Anidro Brasil Extrações Ltda.
Brasil.Brazil.
Exemplo 1 - Composição FIT01Example 1 - Composition FIT01
Esta composição é particularmente adequada para excesso de peso acompanhado de celulite (composição anticelulitica).This composition is particularly suitable for overweight accompanied by cellulite (anti-cellulite composition).
Composição por cápsula de gelatina duraComposition by hard gelatin capsule
Exemplo 2 - Composição FIT02Example 2 - Composition FIT02
Esta composição é particularmente adequada para excesso de peso acompanhado de fadiga (composição estimulante).This composition is particularly suitable for overweight accompanied by fatigue (stimulant composition).
Composição por cápsula de gelatina duraComposition by hard gelatin capsule
Exemplo 3 - Composição FIT03Example 3 - Composition FIT03
Esta composição é particularmente adequada para excesso de peso, com gorduras localizadas e necessidade de inibição do apetite (composição antigorduras localizadas).This composition is particularly suitable for overweight, with localized fat and need for appetite suppression (localized fat composition).
Composição por cápsula de gelatina duraComposition by hard gelatin capsule
SubstânciaSubstance
Quantidade (mg)Quantity (mg)
Extracto de acerola, 26,5%20Acerola extract, 26.5% 20
Extracto de mate40Mate40 Extract
Extracto de chá-verde30Green Tea Extract30
Extracto de tamarindo20Tamarind Extract20
Extracto de chá-de-bugre85Bugre85 Tea Extract
Celulose microcristalina AVICEL PH10137Microcrystalline Cellulose AVICEL PH10137
Estearato de magnésio2Magnesium Stearate2
Sílica coloidal anidra AEROSIL 2001Anhydrous Colloidal Silica AEROSIL 2001
Cápsula de gelatina N°21Gelatin Capsule No. 21
TOTAL235TOTAL235
Exemplo 4 - Composição FIT04Example 4 - Composition FIT04
Esta composição é particularmente adequada para excesso de peso acompanhado de retenção hídrica (composição anti-retenção de líquidos).This composition is particularly suitable for overweight accompanied by water retention (liquid anti-retention composition).
Composição por cápsula de gelatina duraComposition by hard gelatin capsule
SubstânciaSubstance
Quantidade (mg)Quantity (mg)
Extracto de acerola, 26,5%30Acerola extract, 26.5% 30
Extracto de mate30Mate30 Extract
Extracto de chá-verde30Green Tea Extract30
Extracto de tamarindo40Tamarind Extract40
Extracto de cavalinha65Horsetail extract65
Celulose microcristalina AVICEL PH10137Microcrystalline Cellulose AVICEL PH10137
Estearato de magnésio2Magnesium Stearate2
Sílica coloidal anidra AEROSIL 2001Anhydrous Colloidal Silica AEROSIL 2001
Cápsula de gelatina N°21Gelatin Capsule No. 21
TOTAL235TOTAL235
Exemplo 5 - Composição FIT05Example 5 - Composition FIT05
Esta composição é particularmente adequada para excesso de peso acompanhado de ansiedade (composição tranquilizante).This composition is particularly suitable for overweight accompanied by anxiety (tranquilizing composition).
Composição por cápsula de gelatina duraComposition by hard gelatin capsule
SubstânciaSubstance
Quantidade (mg)Quantity (mg)
Extracto de acerola, 26,5%20Acerola extract, 26.5% 20
Extracto de tamarindo25Tamarind Extract25
Extracto de ananás30Pineapple Extract30
Extracto de chá-de-bugre70Bugre70 Tea Extract
Extracto de passiflora50Passionflower extract50
Celulose microcristalina AVICEL PH10137Microcrystalline Cellulose AVICEL PH10137
Estearato de magnésio2Magnesium Stearate2
Sílica coloidal anidra AEROSIL 2001Anhydrous Colloidal Silica AEROSIL 2001
Cápsula de gelatina N°21Gelatin Capsule No. 21
Claims (19)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT10365007A PT103650B (en) | 2007-02-01 | 2007-02-01 | COMPOSITIONS OF VEGETABLE EXTRACTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT10365007A PT103650B (en) | 2007-02-01 | 2007-02-01 | COMPOSITIONS OF VEGETABLE EXTRACTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT103650A PT103650A (en) | 2008-08-29 |
| PT103650B true PT103650B (en) | 2008-11-28 |
Family
ID=40551154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT10365007A PT103650B (en) | 2007-02-01 | 2007-02-01 | COMPOSITIONS OF VEGETABLE EXTRACTS |
Country Status (1)
| Country | Link |
|---|---|
| PT (1) | PT103650B (en) |
-
2007
- 2007-02-01 PT PT10365007A patent/PT103650B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT103650A (en) | 2008-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kumari et al. | Rauvolfia serpentina L. Benth. ex Kurz.: phytochemical, pharmacological and therapeutic aspects | |
| Singh et al. | Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthus emblica): The Sustainer | |
| Zovko Koncic et al. | New insights into dietary supplements used in sport: active substances, pharmacological and side effects | |
| Kaur et al. | Pharmacological actions of Opuntia ficus indica: A Review | |
| Khare | Indian herbal remedies: rational western therapy, ayurvedic and other traditional usage, botany | |
| Khare | Indian medicinal plants: an illustrated dictionary | |
| Street et al. | Commercially important medicinal plants of South Africa: a review | |
| CA2600301A1 (en) | Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition | |
| Enema et al. | Chemistry and pharmacology of aphrodisiac plants: a review | |
| US20060210653A1 (en) | Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition | |
| Barman et al. | Antinociceptive activity of methanol extract of Areca catechu L.(Arecaceae) stems and leaves in mice | |
| Shakya | Drug-induced hepatotoxicity and hepatoprotective medicinal plants: a review | |
| PL209905B1 (en) | Formulation for treating obesity and associated metabolic syndrome | |
| KR101466862B1 (en) | Compositions for reducing weight | |
| Lanje et al. | Medicinal natural drug of Valerian (Valerina Officinalis): an-over review | |
| US7943183B2 (en) | Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition | |
| PD L et al. | Natural remedies for heart diseases | |
| Abou Auda | An updated comprehensive review, systematics and biological activity of medicinal plants used in traditional medicines and their common uses in the Gaza Strip, Palestine | |
| PT103650B (en) | COMPOSITIONS OF VEGETABLE EXTRACTS | |
| RU2259205C1 (en) | Curative-prophylactic agent in disease of urogenital system in men | |
| Yavuz et al. | Herbs potentially enhancing sports performance. | |
| Aslam et al. | Pharmacognostical, phytochemical and pharmacological of Echinops Echinatus Roxb: A comprehensive review | |
| Appiah et al. | Prospects of Croton membranaceus for prostate health | |
| Sultan et al. | Tribulus Terrestris-an Ethnomedical & Phytochemical Review | |
| Samaranayake et al. | Medicinal, culinary and other uses of Cissus quadrangularis (heeressa) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 20070412 |
|
| FG3A | Patent granted, date of granting |
Effective date: 20081114 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20120801 |