PT103650A - COMPOSITIONS OF VEGETABLE EXTRACTS - Google Patents
COMPOSITIONS OF VEGETABLE EXTRACTS Download PDFInfo
- Publication number
- PT103650A PT103650A PT10365007A PT10365007A PT103650A PT 103650 A PT103650 A PT 103650A PT 10365007 A PT10365007 A PT 10365007A PT 10365007 A PT10365007 A PT 10365007A PT 103650 A PT103650 A PT 103650A
- Authority
- PT
- Portugal
- Prior art keywords
- extracts
- composition according
- tamarindus indica
- camellia sinensis
- malpighia glabra
- Prior art date
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Abstract
SÃO DIVULGADAS COMPOSIÇÕES COMPREENDENDO EXTRACTOS VEGETAIS SELECCIONADOS DO GRUPO COMPREENDENDO DE MALPIGHIA GLABRA (L.), CAMELLIA SINENSIS ( L.), ILEX PARAGURIENSIS (S.H), TAMARINDUS INDICA (L:), ANANAS COMOSUS (L:), PAULINIA CUPANA ( H.B.K.), CORDIA ECALYCULATA ( V. ), EQUISETUM ARVENSE (L.) E PASSIFLORA INCARNATA (L.). AS REFERIDAS COMPOSIÇÕES PODEM SER UTILIZADAS COMO SUPLEMENTOS ALIMENTARES EM REGIMES DE EMAGRECIMENTO.COMPOSITIONS ARE DISCLOSED UNDERSTANDING SELECTED VEGETABLE EXTRACTS OF THE GROUP UNDERSTANDING MALPIGHIA GLABRA (L.), CAMELLIA SINENSIS (L.), ILEX PARAGURIENSIS (SH), TAMARINDUS INDICA (L :), ANANAS COMOSUS (L :), PAULINIA CUPANA (HBK) , CORDIA ECALYCULATA (V.), EQUISETUM ARVENSE (L.) AND PASSIFLORA INCARNATA (L.). Said compositions may be used as food supplements in regimens for deagriculture.
Description
DESCRIÇÃO "COMPOSIÇÕES DE EXTRACTOS VEGETAIS"DESCRIPTION " COMPOSITIONS OF VEGETABLE EXTRACTS "
CAMPO DA INVENÇÃO A presente invenção refere-se a composições compreendendo extractos vegetais seleccionados do grupo compreendendoFIELD OF THE INVENTION The present invention relates to compositions comprising vegetable extracts selected from the group comprising
Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.)r Paulinia cupana (H.B.K.), Cordia ecalyculata (V.),Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.) and Paulinia cupana (H.B.K.), Cordia ecalyculata (V.),
Equisetum arvense (L.) e Passiflora incarnata (L.). As composições da presente invenção podem ser utilizadas como suplementos alimentares em regimes de emagrecimento.Equisetum arvense (L.) and Passiflora incarnata (L.). The compositions of the present invention may be used as food supplements in slimming regimens.
ANTECEDENTES DA INVENÇÃO 0 papel dos extractos vegetais é principalmente considerado como adjuvante de acção terapêutica ou simplesmente como complementos alimentares. Desde a antiguidade que se utilizam empiricamente extractos vegetais no tratamento de doenças. Apesar dos grandes desenvolvimentos da farmacologia ocidental, nomeadamente com o isolamento de princípios activos e a síntese química de novas moléculas com propriedades farmacológicas, a fitoterapia tem vindo a ganhar importância no mundo ocidental, nomeadamente por se terem verificado benefícios em determinadas patologias (ver revisão sobre fitoterapia em Cunha, A.P., Silva, 1 A.P. e Roque, O.R. (2003) "Plantas e produtos vegetais em fitoterapia", Fundação Calouste Gulbenkian, Lisboa). A acerola, Malpighia glabra (L.), tem origem nas Antilhas, América Central e norte da América do Sul. O fruto nasce na aceroleira que é um arbusto de até 3 m de altura, e possui vitaminas A, Bl, B2, B3, cálcio, fósforo, ferro e principalmente vitamina C, que em algumas variedades, chega a ser de até 5 gramas por 100 gramas de polpa. Este valor chega a ser cem vezes superior ao da laranja ou limão (Malpighia glabra. (2006, Junho 10). Wikipédía, a enciclopédia livre. Obtido às 16:07, Janeiro 23, 2007 de http://pt.wikipedia.Org/w/index.php7title =Malpighia_glabra&oldid=2280627). Sendo um fonte natural rica em ácido ascórbico (vitamina C) , carotenóides e antocianinas, um extracto deste fruto tem importantes propriedades antioxidantes, antiasténicas e é um bom regenerador celular. O chá-verde, Camellia sinensis (L.), é um arbusto ou pequena árvore, originário da Ásia, particularmente das florestas da Birmânia ao Vietname e da China Meridional. Dos constituintes das suas folhas destacam-se principalmente as xantinas (representadas principalmente por cafeína) e polifenóis. A cafeína proporciona uma acção estimulante sobre o sistema nervoso central, reduzindo a fadiga e inibindo o sono. Os polifenóis mostraram ser inibidores da peroxidação lipídica e captadores de radicais livres (propriedades antioxidantes) . Os flavonóides (polifenóis antioxidantes) têm uma acção lipolítica, por potenciação das catecolaminas, favorecendo o metabolismo natural das gorduras. Tem sido também utilizado como coadjuvante em regimes de emagrecimento (Cunha et al., 2003). 2 0 mate, Ilex paraguariensis (S.H.), é uma árvore ou arbusto espontâneo no norte da Argentina, Paraguai, Uruguai e sul do Brasil. Dos constituintes das suas folhas destacam-se basicamente as xantinas (representadas principalmente por cafeína e teobromina), polifenóis (incluindo taninos), vitaminas e sais minerais. Os taninos têm acção drenante, liporredutora e tonificante. Os extractos desta planta retardam a progressão do bolo alimentar, e permitem o prolongamento da sensação de saciedade. Tem sido utilizado no tratamento da neurastenia, sendo também diurético e bom coadjuvante no tratamento da obesidade (Cunha et al., 2003). O tamarindo, Tamarindus indica (L.), é nativo da índia e Sudeste asiático e cresce perto de regiões tropicais e subtropicais do sub-continente indiano. Este fruto contém pectinas, açúcares simples, ácidos orgânicos (incluindo o ácido tartárico) e sais. A polpa é um laxante suave recomendado na obstipação crónica e/ou resultante da mudança de regime alimentar e tem uma acção anti-inflamatória intestinal. 0 ananás, Ananas comosus (L.), é o fruto de uma planta nativa da América tropical. Este contém principalmente fibras e enzimas proteolíticas, incluindo a bromelaína. A acção anti-inflamatória da bromelaína permite a fragmentação parcial das fibras proteicas que envolvem o tecido celulítico, favorecendo a mobilização dos depósitos gordos das camadas adiposas - acção drenante. É utilizado como coadjuvante no tratamento da celulite (Cunha et al., 2003). O guaraná, Paulinia cupana (H.B.K.), é a semente de um arbusto trepador nativo do Brasil e Uruguai. Contém cafeína, taninos catéquicos, vestígios de teofilina e teobromina. É um 3 estimulante do sistema nervoso central, energizante e permite um aumento do dispêndio calórico. Combate a fadiga psíquica e física que acompanham o excesso de peso e/ou a prática de um regime alimentar com restrições calóricas. Diminui o apetite e é utilizado como coadjuvante no tratamento do excesso de peso (Cunha et ai., 2003). Verificou-se recentemente que uma dieta suplementada com guaraná tem efeitos no metabolismo dos lípidos (Lima, W.P., Carnevali Jr., L.C., Eder, R., Rosa, L.F.B.P.C., Bacchi, E.M. e Seelaender, M.C.L. (2005) "Lipid metabolism in Trained rats: Effect of guarana (Paulinia cupana Mart.) supplementation", Clinicai Nutrition, 24, 1019-1028). É muito utilizado por desportistas para melhorar o desempenho físico. O chá-de-Bugre, Cordia ecalyculata (V.), é preparado a partir de folhas de uma pequena árvore originária da América do Sul. Este chá contém polifenóis (incluindo taninos), potássio, alantoína e ácido alantóico. É conhecido como supressor do apetite, diurético e eficaz na redução de gorduras localizadas (Taylor, T. (2005) "The healing power of rainforest. A guide to understanding and using herbal medicinais herbs", Square One Publishers, NY). A cavalinha, Equisetum arvense (L.), é uma planta herbácea vivaz nativa da Europa, Norte de África, Sul da Ásia e América em solos argilo-siliciosos, húmidos e sombrios. Existe em quase todo o território de Portugal. É rica em sais minerais, flavonóides e taninos, sendo a quercetina o constituinte activo. Os flavonóides conferem uma acção diurética, evitando a formação de cálculos renais e biliares. A cavalinha é recomendada quando se pretenda aumentar a diurese, como veículo da redução da retenção de líquidos, particularmente no caso da obesidade 4 acompanhada de retenção de líquidos. Tem também uma acção remineralizante (Cunha et al., 2003). A passiflora, Passiflora incarnata (L.), também conhecida por maracujá, é uma trepadeira arbustiva espontânea na América tropical. As suas partes aéreas têm inúmeros flavonóides entre os quais a vitexina. Tem uma acção sedativa e tranquilizante, prevenindo nomeadamente a irritabilidade em determinados regimes de emagrecimento (Cunha et al., 2003; Dhawan, K., Dhawan, S. e Sharma, A. (2004) "Passiflora: a review update", Journal of Ethnopharmacology 94, 1-23).BACKGROUND OF THE INVENTION The role of the plant extracts is mainly considered as adjuvant of therapeutic action or simply as food supplements. Since ancient times empirically used plant extracts in the treatment of diseases. In spite of major developments in Western pharmacology, particularly with the isolation of active principles and the chemical synthesis of new molecules with pharmacological properties, phytotherapy has gained importance in the Western world, especially since there have been benefits in certain pathologies (see review on Phytotherapy in Cunha, AP, Silva, 1 AP and Roque, OR (2003) " Plants and plant products in phytotherapy ", Calouste Gulbenkian Foundation, Lisbon). The acerola, Malpighia glabra (L.), originates in the Antilles, Central America and north of South America. The fruit is born in the cherry tree which is a shrub up to 3 m high, and has vitamins A, Bl, B2, B3 , calcium, phosphorus, iron and especially vitamin C, which in some varieties, amounts to up to 5 grams per 100 grams of pulp. This value reaches 100 times greater than that of the orange or lemon (Malpighia glabra.) (2006, June 10). /w/index.php7title = Malpighia_glabra & oldid = 2280627). Being a natural source rich in ascorbic acid (vitamin C), carotenoids and anthocyanins, an extract of this fruit has important antioxidant properties, antiasthenic and is a good cell regenerator. Green tea, Camellia sinensis (L.), is a shrub or small tree, originating in Asia, particularly from the forests of Burma to Vietnam and South China. The constituents of its leaves stand out mainly the xanthines (represented mainly by caffeine) and polyphenols. Caffeine provides a stimulant action on the central nervous system, reducing fatigue and inhibiting sleep. Polyphenols have been shown to be inhibitors of lipid peroxidation and free radical scavengers (antioxidant properties). Flavonoids (antioxidant polyphenols) have a lipolytic action, by potentiation of catecholamines, favoring the natural metabolism of fats. It has also been used as a coadjuvant in slimming regimens (Cunha et al., 2003). The mate, Ilex paraguariensis (S.H.), is a spontaneous tree or shrub in northern Argentina, Paraguay, Uruguay and southern Brazil. The constituents of its leaves stand out basically the xanthines (represented mainly by caffeine and theobromine), polyphenols (including tannins), vitamins and minerals. Tannins have a draining, toning and toning action. The extracts from this plant slow the progression of the bolus, and allow the prolongation of the sensation of satiety. It has been used in the treatment of neurasthenia, being also a diuretic and a good adjuvant in the treatment of obesity (Cunha et al., 2003). Tamarind, Tamarindus indica (L.), is native to India and Southeast Asia and grows near tropical and subtropical regions of the Indian subcontinent. This fruit contains pectins, simple sugars, organic acids (including tartaric acid) and salts. The pulp is a mild laxative recommended in chronic constipation and / or resulting from change in diet and has an anti-inflammatory bowel action. Pineapples, Ananas comosus (L.), are the fruit of a plant native to tropical America. This mainly contains fibers and proteolytic enzymes, including bromelain. The anti-inflammatory action of bromelain allows the partial fragmentation of the protein fibers that surround the cellulite tissue, favoring the mobilization of fatty deposits of the adipose layers - draining action. It is used as a coadjuvant in the treatment of cellulite (Cunha et al., 2003). Guarana, Paulinia cupana (H.B.K.), is the seed of a climbing shrub native to Brazil and Uruguay. Contains caffeine, cathectic tannins, traces of theophylline and theobromine. It is a 3-stimulant of the central nervous system, energizing and allows an increase in caloric expenditure. Combat psychic and physical fatigue that accompany overweight and / or the practice of a calorie-restricted diet. It decreases the appetite and is used as a coadjuvant in the treatment of overweight (Cunha et al., 2003). It has recently been found that a guarana-supplemented diet has effects on lipid metabolism (Lima, WP, Carnevali Jr., LC, Eder, R., Rosa, LFBPC, Bacchi, EM and Seelaender, MCL (2005) " Lipid metabolism in Trained rats: Effect of guarana (Paulinia cupana Mart.) supplementation ", Clinical Nutrition, 24, 1019-1028). It is widely used by athletes to improve physical performance. Tea-de-Bugre, Cordia ecalyculata (V.), is prepared from leaves of a small tree native to South America. This tea contains polyphenols (including tannins), potassium, allantoin and allantoic acid. It is known as an appetite suppressant, diuretic and effective in reducing localized fats (Taylor, T. (2005) "The healing power of rainforest." The horsetail, Equisetum arvense (L.), is a vivacious herbaceous plant native to Europe, North Africa, South Asia and America in clayey, siliceous, moist and damp soils. It exists in almost the entire territory of Portugal. It is rich in mineral salts, flavonoids and tannins, with quercetin being the active constituent. Flavonoids confer a diuretic action, preventing the formation of kidney and gallstones. Horsetail is recommended when it is desired to increase diuresis as a vehicle for reducing fluid retention, particularly in the case of obesity 4 accompanied by fluid retention. It also has a remineralizing action (Cunha et al., 2003). Passiflora, incarnata (L.), also known as passion fruit, is a spontaneous bushberry in tropical America. Its aerial parts have numerous flavonoids including vitexin. It has a sedative and tranquilizing action, preventing, in particular, irritability in certain weight-loss regimens (Cunha et al., 2003; Dhawan, K., Dhawan, S. and Sharma, A. (2004) "Passiflora: a review update ", Journal of Ethnopharmacology 94, 1-23).
Estas e outras plantas e respectivos extractos são tradicionalmente utilizados separadamente. Os complementos fitoterapêuticos são principalmente compostos de uma só planta na forma, por exemplo, de pó. A combinação de vários extractos de plantas permite não só a acção individual de cada extracto, como o estabelecimento de sinergias que reforçam e potencializam a acção das plantas (ver revisão por Williamson, E.M. (2001) "Synergy and other interactions in phytomedicines", Phytomedicine, 8(5), 401-409). Estas interacções sinérgicas são fundamentais na fitoterapia pois permitem explicar as frequentes dificuldades no isolamento de um único principio activo, e também explicam a eficácia de doses aparentemente baixas de constituintes activos num produto fitoterapêutico. As interacções sinérgicas estão não só documentadas para constituintes num extracto total de uma única planta, como também entre diferentes plantas numa formulação. Williamson (2001) descreve vários exemplos de sinergia entre diferentes plantas numa formulação, referindo que a avaliação destes efeitos sinérgicos é naturalmente complicada. É o caso de formulações, por exemplo na medicina Chinesa, que consistem por 5 vezes em sete ou mais extractos vegetais, na maioria dos casos sem caracterização dos extractos e dos processos de extracção, com plantas provenientes de crescimento espontâneo e sob condições não controladas. É, portanto, necessário que as composições de fitoterapia se baseiem em parâmetros de qualidade, reprodutibilidade e segurança (Ong, E.S. (2004) "Extraction methods and Chemical standardization of botanicals and herbal preparations", Journal of Chromatography B, 812, 23-33) . Além disso, é igualmente desejável que do ponto de vista do consumidor, a administração seja cómoda, isto é, fácil, rápida, indolor e que o extracto não necessite, por exemplo, de manipulações adicionais. O emagrecimento é muito difícil para alguns indivíduos. O ganho de peso resulta quando a ingestão calórica num indivíduo excede o número de calorias gastas como energia. Numa tentativa de perder peso, os indivíduos pretendem frequentemente atingir um déficit calórico (i. e., diminuindo a ingestão calórica de modo que as calorias gastas como energia excedam a ingestão calórica) . Geralmente, isto resulta numa resposta adaptativa de diminuição da taxa metabólica basal e perda de músculo esquelético, o que pode tornar ainda mais difícil a manutenção do peso (assim que o peso desejado for atingido). É pois desejável que um programa de emagrecimento inclua complementos alimentares que auxiliem o organismo na manutenção do seu equilíbrio energético e ao mesmo tempo estimulem ou induzam processos indirectos de perda de peso, tais como lipólise, supressão do apetite, diurese, termogénese, etc. Alguns extractos vegetais já incluem algumas destas propriedades. No entanto a combinação de vários extractos (3, 4, 5, 6 ou mais) permitirá não só uma abordagem multifacetada da perda de peso como quantidades mais baixas desses mesmos extractos. Esta 6 abordagem é particularmente desejada para indivíduos que não podem ou preferem não utilizar fármacos e, que no caso de indivíduos obesos, esses fármacos podem ser contra-indicados devido ao risco de potenciais efeitos colaterais prejudiciais.These and other plants and extracts thereof are traditionally used separately. Phytotherapeutic supplements are mainly composed of a single plant in the form of, for example, powder. The combination of various plant extracts allows not only the individual action of each extract, but also the establishment of synergies that reinforce and potentiate the action of plants (see review by Williamson, EM (2001) " Synergy and other interactions in phytomedicines " Phytomedicine, 8 (5), 401-409). These synergistic interactions are fundamental in phytotherapy as they explain the frequent difficulties in isolating a single active ingredient and also explain the efficacy of apparently low doses of active constituents in a phytotherapeutic product. Synergistic interactions are not only documented for constituents in a total extract of a single plant, but also between different plants in a formulation. Williamson (2001) describes various examples of synergy between different plants in a formulation, noting that the evaluation of these synergistic effects is naturally complicated. It is the case of formulations, for example in Chinese medicine, which consist of 5 times in seven or more plant extracts, in most cases without characterization of the extracts and the extraction processes, with spontaneously growing plants and under uncontrolled conditions. It is therefore necessary that phytotherapy compositions are based on parameters of quality, reproducibility and safety (Ong, ES (2004) " Extraction methods and Chemical standardization of botanicals and herbal preparations ", Journal of Chromatography B, 812, 33). Moreover, it is also desirable that from the consumer's point of view, administration is convenient, i.e., easy, quick, painless and that the extract does not require, for example, additional manipulations. Weight loss is very difficult for some individuals. Weight gain results when the caloric intake in an individual exceeds the number of calories expended as energy. In an attempt to lose weight, individuals often intend to achieve a calorie deficit (i.e., lowering calorie intake so that calories expended as energy exceed caloric intake). Generally, this results in an adaptive response of decreased basal metabolic rate and loss of skeletal muscle, which may make it even more difficult to maintain weight (as soon as desired weight is achieved). It is therefore desirable for a slimming program to include dietary supplements which assist the body in maintaining its energy balance and at the same time stimulate or induce indirect processes of weight loss, such as lipolysis, appetite suppression, diuresis, thermogenesis, etc. Some plant extracts already include some of these properties. However the combination of various extracts (3, 4, 5, 6 or more) will allow not only a multifaceted approach to weight loss but also lower amounts of those extracts. This approach is particularly desired for individuals who can not or do not prefer to use drugs and, in the case of obese individuals, such drugs may be contraindicated because of the risk of potential harmful side effects.
De acordo com o exposto, existe a necessidade na técnica para um suplemento alimentar que promova a perda de peso, mantendo o equilíbrio energético e muscular, ao mesmo tempo que seja seguro e de cómoda utilização.Accordingly, there is a need in the art for a food supplement that promotes weight loss while maintaining energy and muscle balance, while being safe and convenient to use.
SUMÁRIO DA INVENÇÃO A presente invenção refere-se a uma composição de extractos vegetais caracterizada por compreender uma combinação de, pelo menos, três extractos seleccionados do grupo compreendendo Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.) , Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equisetum arvense (L.) e Passiflora incarnata (L.) . Numa Forma de realização preferida da presente invenção, a composição é caracterizada por compreender uma combinação de quatro ou mais dos referidos extractos vegetais.The present invention relates to a plant extracts composition comprising a combination of at least three extracts selected from the group comprising Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH) , Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equisetum arvense (L.) and Passiflora incarnata (L.). In a preferred embodiment of the present invention, the composition is characterized in that it comprises a combination of four or more of said plant extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.) , Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Ananas comosus (L.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 16-20%, 8-12%, 11-15%, 8-12% e 47-51%, respectivamente e numa forma muito 7 preferida, numa forma de dosagem unitária contendo cerca de 35, 20, 25, 20 e 95 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention, the composition is characterized in that it comprises extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Ananas comosus (L. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 16-20%, 8-12%, 11-15%, 8-12% and 47-51%, respectively and in a very preferred form, in a form of dosage unit containing about 35, 20, 25, 20 and 95 mg, respectively, of dry extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Paulinia cupana (H.B.K.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 16-20%, 13-17%, 18-22%, 18-22% e 24-28%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 35, 30, 40, 40 e 50 mg, respectivamente, de extractos secos.In a preferred embodiment of the invention the composition is characterized in that it comprises extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Paulinia cupana (HBK) , in any proportion. In a more preferred form, in a weight ratio of extracts of about 16-20%, 13-17%, 18-22%, 18-22% and 24-28% respectively and in a most preferred form in a dosage form containing about 35, 30, 40, 40 and 50 mg, respectively, of dry extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Cordia ecalyculata (V.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 8-12%, 13-17%, 18-22%, 8-12% e 43-47%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 20, 30, 40, 20 e 85 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention the composition is characterized in that it comprises extracts of said Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Cordia ecalyculata (V. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 8-12%, 13-17%, 18-22%, 8-12% and 43-47% respectively and in a most preferred form in a dosage form containing about 20, 30, 40, 20 and 85 mg, respectively, of dry extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.)f Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.) e Equisetum arvense (I.), em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 13-17%, 13-17%, 13-17%, 18-22% e 31-35%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo 8 cerca de 30, 30, 30, 40 e 65 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention the composition is characterized in that it comprises extracts of said Malpighia glabra (L.) f Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L.) and Equisetum arvense (I. ) in any proportion. In a more preferred form, in a weight ratio of extracts of about 13-17%, 13-17%, 13-17%, 18-22% and 31-35% respectively and in a most preferred form in a dosage form containing about 30, 30, 30, 40 and 65 mg, respectively, of dry extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender extractos das referidas Malpighia glabra (L.), Tamarindus indica (L.), Ananas comosus (L.)r Cordia ecalyculata (V.), e Passiflora incarnata (L.) , em quaisquer proporções. Numa forma mais preferida, numa proporção em peso de extractos de cerca de 8-12%, 11-15%, 13-17%, 34-38% e 24-28%, respectivamente e numa forma muito preferida, numa forma de dosagem unitária contendo cerca de 20, 25, 30, 70 e 50 mg, respectivamente, de extractos secos.In a preferred embodiment of the present invention the composition is characterized in that it comprises extracts of said Malpighia glabra (L.), Tamarindus indica (L.), Ananas comosus (L.) Cordia ecalyculata (V.), and Passiflora incarnata L.) in any proportion. In a more preferred form, in a weight ratio of extracts of about 8-12%, 11-15%, 13-17%, 34-38% and 24-28%, respectively and in a most preferred form, in a dosage form containing about 20, 25, 30, 70 and 50 mg, respectively, of dry extracts.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por ser utilizada na preparação de um suplemento alimentar para regimes de emagrecimento.In a preferred embodiment of the present invention, the composition is characterized in that it is used in the preparation of a dietary supplement for slimming regimens.
Numa forma de realização preferida da presente invenção, a composição é caracterizada por compreender adicionalmente um ou mais adjuvantes e/ou veiculos farmaceuticamente aceitáveis.In a preferred embodiment of the present invention, the composition is characterized in that it additionally comprises one or more pharmaceutically acceptable adjuvants and / or vehicles.
DESCRIÇÃO DETALHADA DA INVENÇÃO A presente invenção refere-se a composições compreendendo a mistura de, pelo menos, três extractos vegetais seleccionados do grupo compreendendo Malpighia glabra (L.)r Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equisetum arvense (L.) e Passíflora incarnata (L.). As composições da presente invenção podem ser utilizadas como suplementos alimentares em regimes de emagrecimento. 9DETAILED DESCRIPTION OF THE INVENTION The present invention relates to compositions comprising mixing at least three plant extracts selected from the group comprising Malpighia glabra (L.) Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica L.), Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equisetum arvense (L.) and Passíflora incarnata (L.). The compositions of the present invention may be used as food supplements in slimming regimens. 9
Extractos vegetaisVegetable extracts
Os extractos vegetais das composições da presente invenção são extractos secos de plantas medicinais. Estas plantas são cultivadas com técnicas de agricultura biológica. As extracções são realizadas em plantas seleccionadas e utilizando técnicas de extracção com solventes inócuos. A secagem dos extractos é realizada, de um modo preferido, por atomização. Os processos e metodologias são bem conhecidas dos especialistas na técnica e estão de acordo com certificados de qualidade reconhecidos internacionalmente. Os extractos são caracterizados com base nas caracteristicas físicas (e. g. , aspecto, cor, odor/sabor, pH em solução, solubilidade, etc.) e microbiológicas (e. g., ensaios para a presença de estirpes bacterianas patogénicas). Além disso, é quantificado um princípio activo padronizado específico para cada extracto. No extracto de Malpighia glabra (L.) (acerola) o princípio activo quantificado é o ácido ascórbico. No extracto de Ilex paraguariensis (S.H.) (mate) os princípios activos quantificados são a cafeína e a teobromina. No extracto de Camellia sinensis (L.) (chá-verde) os princípios activos quantificados são polifenóis e EGCG (epigalhocatequina galhato). No extracto de Tamarindus indica (L.) (tamarindo) o princípio activo quantificado é o ácido tartárico. No extracto de Ananas comosus (L.) (ananás) o princípio activo quantificado é a bromelaína. No extracto de Paulinia cupana (H.B.K.) (guaraná) os princípios activos quantificados são cafeína e taninos. No extracto de Cordia ecalyculata (V.) (chá-de-bugre) os princípios activos quantificados são taninos. No extracto de Equisetum arvense (L.) (cavalinha) o princípio activo quantificado é a quercetina. No extracto de Passiflora incarnata (L.) (passiflora) o princípio activo quantificado é a vitexina. 10The plant extracts of the compositions of the present invention are dried extracts of medicinal plants. These plants are cultivated with organic farming techniques. The extractions are carried out in selected plants and using extraction techniques with innocuous solvents. The drying of the extracts is preferably carried out by atomization. Processes and methodologies are well known to those skilled in the art and are in accordance with internationally recognized quality certificates. The extracts are characterized on the basis of physical (e.g., appearance, color, odor / taste, pH in solution, solubility, etc.) and microbiological characteristics (e.g., assays for the presence of pathogenic bacterial strains). In addition, a standardized active principle specific to each extract is quantified. In the extract of Malpighia glabra (L.) (acerola) the active ingredient quantified is ascorbic acid. In the extract of Ilex paraguariensis (S.H.) (mate) the quantified active principles are caffeine and theobromine. In the extract of Camellia sinensis (L.) (tea-green) the quantified active principles are polyphenols and EGCG (epigalhocatechin gallate). In the extract of Tamarindus indica (L.) (tamarind) the active ingredient quantified is tartaric acid. In the extract of Ananas comosus (L.) (pineapple) the quantified active principle is bromelain. In the extract of Paulinia cupana (H.B.K.) (guaraná) the quantified active principles are caffeine and tannins. In the extract of Cordia ecalyculata (V.) (tea-de-bugre) the quantified active principles are tannins. In Equisetum arvense (L.) extract (mackerel) the quantified active principle is quercetin. In the extract of Passiflora incarnata (L.) (passiflora) the quantified active principle is vitexin. 10
Combinações de extractos A presente invenção refere-se a composições caracterizadas por compreenderem combinações de, pelo menos, três extractos seleccionados do grupo compreendendo Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (S.H.), Tamarindus indica (L.), Ananas comosus (L.), Paulinia cupana (H.B.K.), Cordia ecalyculata (V.), Equisetum arvense (L.) e Passiflora incarnata (L.) . A escolha do número e tipos de extractos compreendidos nas composições baseia-se por um lado nas propriedades reconhecidas de cada extracto (como já referidas) e nas indicações especificas pretendidas para essa mesma composição. No âmbito de um programa de emagrecimento, estas indicações especificas podem ser não só individuais como sazonais e podem incluir, por exemplo, indicações anticeluliticas, antiasténicas, de supressão do apetite, etc. As quantidades de cada extracto numa determinada composição têm como referência de segurança a Dose Diária Recomendada (DDR) para cada um dos princípios activos padronizados ou extractos caracterizados. De acordo com o exposto, o conteúdo de ácido ascórbico no extracto de acerola utilizado não deverá ultrapassar 1000 mg (DDR), a quantidade de extracto de mate utilizado não deverá ultrapassar 3 g, o conteúdo de cafeína no extracto de chá-verde utilizado não deverá ultrapassar 240-320 mg, a quantidade de extracto de tamarindo utilizado não deverá ultrapassar 1-2 g, a quantidade de extracto de ananás utilizado não deverá ultrapassar 2 g, o conteúdo de cafeína no extracto de guaraná utilizado não deverá ultrapassar 100 mg, a quantidade de extracto de cavalinha utilizado não deverá ultrapassar 1-2 g e o conteúdo de vitexina 11 no extracto de passiflora utilizado não deverá ultrapassar 100 mg.The present invention relates to compositions comprising combinations of at least three extracts selected from the group comprising Malpighia glabra (L.), Camellia sinensis (L.), Ilex paraguariensis (SH), Tamarindus indica (L .), Ananas comosus (L.), Paulinia cupana (HBK), Cordia ecalyculata (V.), Equisetum arvense (L.) and Passiflora incarnata (L.). The choice of the number and types of extracts comprised in the compositions is based on the one hand on the recognized properties of each extract (as already mentioned) and on the specific indications desired for the same composition. Within a weight-loss program, these specific indications may be not only individual but also seasonal, and may include, for example, anti-cellulite, antiasthenic, appetite-suppressing, and so on indications. The amounts of each extract in a given composition are based on the Recommended Daily Dose (DDR) for each of the standard active ingredients or characterized extracts. Accordingly, the ascorbic acid content in the acerola extract used should not exceed 1000 mg (RDA), the amount of mate extract used should not exceed 3 g, the caffeine content in the green tea extract used should not exceed 3 g. should exceed 240-320 mg, the amount of tamarind extract used should not exceed 1-2 g, the amount of pineapple extract used should not exceed 2 g, the caffeine content in the guarana extract used should not exceed 100 mg, the amount of horsetail extract used should not exceed 1-2 g and the content of vitexin 11 in the passiflora extract used should not exceed 100 mg.
AdministraçãoAdministration
De acordo com o método de administração pretendido, as composições da presente invenção compreenderão tipicamente um ou mais adjuvantes e/ou veículos farmaceuticamente aceitáveis convencionais. A formulação de fármacos é discutida de um modo geral em, por exemplo, Hoover, John E. (1975) "Remington's Pharmaceutical Sciences", Mack Publishing Co., Easton, PA..According to the intended method of administration, the compositions of the present invention will typically comprise one or more conventional pharmaceutically acceptable adjuvants and / or vehicles. The drug formulation is discussed generally in, for example, Hoover, John E. (1975) " Remington's Pharmaceutical Sciences ", Mack Publishing Co., Easton, PA ..
As formas de dosagem sólidas para administração oral incluem, por exemplo, cápsulas, comprimidos, pílulas, gomas, pós e granulados. Nessas formas de dosagem sólidas, as composições dos referidos extractos são vulgarmente combinadas com um ou mais adjuvantes, e. g.; lactose, sacarose, pó de amido, ésteres celulósicos de ácidos alcanóicos, ésteres alquílicos de celulose, talco, ácido esteárico, estearato de magnésio, óxido de magnésio, sais de sódio e cálcio de ácidos fosfóricos e sulfúricos, gelatina, goma de acácia, alginato de sódio, polivinilpirrolidona e/ou álcool polivinílico e, depois, comprimidas ou encapsulados para administração conveniente. Essas cápsulas ou comprimidos podem conter uma formulação de libertação controlada, como podem ser proporcionadas numa dispersão da composição dos extractos. No caso de cápsulas, comprimidos e pílulas, as formas de dosagem também podem compreender agentes de tamponamento, tais como citrato de sódio ou magnésio ou carbonato ou bicarbonato de cálcio. Os comprimidos e pílulas podem ser adicionalmente preparados com revestimentos entéricos. 12Solid dosage forms for oral administration include, for example, capsules, tablets, pills, gums, powders and granules. In such solid dosage forms, the compositions of said extracts are commonly combined with one or more adjuvants, e.g. g .; lactose, sucrose, starch powder, cellulosic esters of alkanoic acids, alkyl esters of cellulose, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, gelatin, acacia gum, alginate sodium, polyvinylpyrrolidone and / or polyvinyl alcohol and then compressed or encapsulated for convenient administration. Such capsules or tablets may contain a controlled release formulation, as may be provided in a dispersion of the composition of the extracts. In the case of capsules, tablets and pills, the dosage forms may also comprise buffering agents, such as sodium or magnesium citrate or calcium carbonate or bicarbonate. The tablets and pills may be further prepared with enteric coatings. 12
As formas de dosagem líquidas para administração oral incluem, por exemplo, emulsões, soluções, suspensões, xaropes e elixires farmaceuticamente aceitáveis contendo diluentes inertes utilizados habitualmente na técnica (e. g., água). Essas composições também podem compreender adjuvantes, tais como agentes de humidificação, emulsionantes, de suspensão, aromatizantes (e.g., edulcorante) e/ou de fragrância.Liquid dosage forms for oral administration include, for example, pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used in the art (e.g., water). Such compositions may also comprise adjuvants, such as wetting, emulsifying, suspending, flavoring (e.g., sweetening) and / or fragrance agents.
Também podem ser utilizados outros adjuvantes e modos de administração bem conhecidos na técnica.Other adjuvants and modes of administration well known in the art may also be used.
Os seguintes exemplos pretendem ser ilustrativos e não limitativos, e representam formas de realização específicas da presente invenção.The following examples are intended to be illustrative and not limiting, and represent specific embodiments of the present invention.
EXEMPLOSEXAMPLES
Os exemplos de composições que se seguem foram preparadas com extractos vegetais caracterizados e certificados para utilização em fitoterapêutica. Cada extracto em pó seco contém um principio activo padronizado e devidamente quantificado. 0 Extracto de acerola a 26,5%, contém 28% de ácido ascórbico; o Extracto de mate contém 9% de cafeína e 0,35% de teobromina; o Extracto de chá-verde contém 28% de polifenóis e 3,79% de EGCG (epigalhocatequina galhato); o Extracto de tamarindo contém 5% de ácido tartárico; o Extracto de ananás contém 80 GDU/g de bromelaína; o Extracto de guaraná contém 10% de cafeína e 1% de taninos; o Extracto de chá-de-bugre contém 6,7% de taninos: o Extracto de cavalinha contém 2,74% de quercetina; o Extracto de passiflora contém 3,8% de vitexina. Os extractos secos são 13 fornecidos, por exemplo, pela Anidro Brasil Extrações Ltda, Brasil.The following examples of compositions were prepared with characterized and certified herbal extracts for use in phytotherapy. Each dry powder extract contains a standardized and properly quantified active ingredient. 0 26.5% acerola extract contains 28% ascorbic acid; Mate extract contains 9% caffeine and 0.35% theobromine; Green Tea Extract contains 28% polyphenols and 3.79% EGCG (epigalhocatechin gallate); tamarind extract contains 5% tartaric acid; Pineapple extract contains 80 GDU / g of bromelain; Guarana extract contains 10% caffeine and 1% tannins; Tea extract contains 6.7% tannins: Horsetail Extract contains 2.74% quercetin; Passiflora extract contains 3.8% vitexin. The dried extracts are provided, for example, by Anidro Brasil Extrações Ltda, Brazil.
Exemplo 1 - Composição FIT01Example 1 - Composition FIT01
Esta composição é particularmente adequada para excesso de peso acompanhado de celulite (composição anticelulitica).This composition is particularly suitable for overweight accompanied by cellulite (anti-cellulite composition).
Composição por cápsula de gelatina duraComposition per hard gelatin capsule
Substância Quantidade (mg) Extracto de acerola, 26,5% 35 Extracto de mate 25 Extracto de chá-verde 20 Extracto de tamarindo 20 Extracto de ananás 95 Celulose microcristalina AVICEL PH101 37 Estearato de ! magnésio 2 Sílica coloidal anidra AEROSIL 200 1 Cápsula de gelatina N°2 1 TOTAL 235 14Substance Amount (mg) Acerola extract, 26.5% Matte extract 25 Green tea extract 20 Tamarind extract 20 Pineapple extract 95 Microcrystalline cellulose AVICEL PH101 37 Stearate of! Magnesium 2 Silica colloidal anhydrous AEROSIL 200 1 Gelatin capsule No. 2 1 TOTAL 235 14
Exemplo 2 - Composição FIT02Example 2 - Composition FIT02
Esta composição é particularmente adequada para excesso de peso acompanhado de fadiga (composição estimulante).This composition is particularly suitable for overweight accompanied by fatigue (stimulant composition).
Composição por cápsula de gelatina duraComposition per hard gelatin capsule
Substância Quantidade (mg) Extracto de acerola, 26,5% 35 Extracto de mate 40 Extracto de chá-verde 30 Extracto de tamarindo 40 Extracto de guaraná 50 Celulose microcristalina AVICEL PH101 37 Estearato de magnésio 2 Sílica coloidal anidra AEROSIL 200 1 Cápsula de gelatina N°2 1 TOTAL 235 15Substance Amount (mg) Acerola extract, 26.5% Matte extract 40 Tea extract green 30 Tamarind extract 40 Guarana extract 50 Microcrystalline cellulose AVICEL PH101 37 Magnesium stearate 2 Colloidal anhydrous silica AEROSIL 200 1 Gelatin capsule No. 2 1 TOTAL 235 15
Exemplo 3 - Composição FIT03Example 3 - Composition FIT03
Esta composição é particularmente adequada para excesso de peso, com gorduras localizadas e necessidade de inibição do apetite (composição antigorduras localizadas).This composition is particularly suitable for overweight, with localized fats and need for appetite suppression (localized antifung composition).
Composição por cápsula de gelatina duraComposition per hard gelatin capsule
Substância Quantidade (mg) Extracto de acerola, 26,5% 20 Extracto de mate 40 Extracto de chá-verde 30 Extracto de tamarindo 20 Extracto de chá-de-bugre 85 Celulose microcristalina AVICEL PH101 37 Estearato de magnésio 2 Sílica coloidal anidra AEROSIL 200 1 Cápsula de < gelatina N°2 1 TOTAL 235 16Substance Amount (mg) Acerola extract 26.5% Matte extract 40 Green tea extract 30 Tamarind extract 20 Tea extract 56 Microcrystalline cellulose AVICEL PH101 37 Magnesium stearate 2 Colloidal anhydrous silica AEROSIL 200 1 Capsule of < Gelatin No. 2 1 TOTAL 235 16
Exemplo 4 - Composição FIT04Example 4 - FIT04 Composition
Esta composição é particularmente adequada para excesso de peso acompanhado de retenção hídrica (composição anti-retenção de líquidos).This composition is particularly suitable for overweight accompanied by water retention (anti-retention composition of liquids).
Composição por cápsula de gelatina duraComposition per hard gelatin capsule
Substância Quantidade (mg) Extracto de acerola, 26,5% 30 Extracto de mate 30 Extracto de chá-verde 30 Extracto de tamarindo 40 Extracto de cavalinha 65 Celulose microcristalina AVICEL PH101 37 Estearato de magnésio 2 Sílica coloidal anidra AEROSIL 200 1 Cápsula de gelatina N°2 1 TOTAL 235 17Substance Amount (mg) Acerola extract 26.5% Matte extract 30 Green tea extract 30 Tamarind extract 40 Horsetail extract 65 Microcrystalline cellulose AVICEL PH101 37 Magnesium stearate 2 Colloidal anhydrous silica AEROSIL 200 1 Gelatin capsule No. 2 1 TOTAL 235 17
Exemplo 5 - Composição FIT05Example 5 - Composition FIT05
Esta composição é particularmente adequada para excesso de peso acompanhado de ansiedade (composição tranquilizante).This composition is particularly suitable for overweight accompanied by anxiety (tranquilizer composition).
Composição por cápsula de gelatina duraComposition per hard gelatin capsule
Substância Quantidade (mg) Extracto de acerola, 26,5% 20 Extracto de tamarindo 25 Extracto de ananás 30 Extracto de chá-de-bugre 70 Extracto de passiflora 50 Celulose microcristalina AVICEL PH101 37 Estearato de magnésio 2 Sílica coloidal anidra AEROSIL 200 1 Cápsula ( de i gelatina N°2 1 TOTAL 235Substance Amount (mg) Acerola Extract, 26.5% 20 Tamarind Extract 25 Pineapple Extract 30 Tea Extract 70 Passiflora Extract 50 Microcrystalline Cellulose AVICEL PH101 37 Magnesium Stearate 2 Colloidal Silica Anhydrous AEROSIL 200 1 Capsule (gelatin No. 2 1 TOTAL 235
Lisboa, 1 de Fevereiro de 2007 18Lisbon, 1 February 2007 18
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