PL8792B1 - A method of producing elastic, easily dissolving lozenges, pills, medicinal products. - Google Patents

A method of producing elastic, easily dissolving lozenges, pills, medicinal products. Download PDF

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Publication number
PL8792B1
PL8792B1 PL8792A PL879227A PL8792B1 PL 8792 B1 PL8792 B1 PL 8792B1 PL 8792 A PL8792 A PL 8792A PL 879227 A PL879227 A PL 879227A PL 8792 B1 PL8792 B1 PL 8792B1
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PL
Poland
Prior art keywords
pills
medicinal products
producing elastic
easily dissolving
lozenges
Prior art date
Application number
PL8792A
Other languages
Polish (pl)
Filing date
Publication date
Application filed filed Critical
Publication of PL8792B1 publication Critical patent/PL8792B1/en

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Description

Pastylki, pigulki i podobne wyroby lecznicze wytwarza sie wedlug najrozma¬ itszych przepisów zaleznie od zamierzone¬ go ich uzycia.Pastylki i podobne wyroby leczni¬ cze wyrabia sie badz z masy za¬ sadniczej np. masla kakaowego i od¬ nosnego srodka leczniczego, badz z ze¬ latyny glicerynowej, nastepnie masa zasadnicza moze sie skladac z dek¬ stryny, cukru, skrobi, gliceryny i ciala czynnego i wreszcie pastylki wyrabia sie równiez zapomoca sprasowywania srodka leczniczego i mieszaniny zawierajacej skrobie.Pastylki rzeczone wykazuja jednak rozmaite niedogodnosci. Pastylki z masla kakaowego topi sie zbyt latwo, pastylki zas z zelatyny glicerynowej sa gietkie i nie posiadaja dostatecznej wytrzyma¬ losci.Obecnie wykryto, iz pastylki i wyroby podobne, które zawieraja w masie zasad¬ niczej oprócz odnosnego srodka czynnego i np. nieznacznej ilosci Suce. Liauir., po¬ nadto jeden lub wiecej nadajacych sie do tego celu srodków hydrotropowych, np, p-toluolosulfonianu sodowego lub sul¬ fonian sodowy, jako takie lub zmieszane z obojetnemi, latworozpuszczajacemi cia¬ lami np. boraksem lub cukrem mlecznym i które to wyroby zapomoca ugniatania mieszaniny powyzszej z woda i mala ilo¬ scia sluzu tragantowego staja sie sprezy-stemi, nie wykazuja niedogodnosci, o któ¬ rych mowa powyzej.Postepuje sie np. w sposób nastepu¬ jacy: 100 czesci wagowych protargolu, 430 cz. wag. p-toluolosulfonianu sodo¬ wego, 284 cz. wag. boraksu i 16 cz. wag. Suce. Liauir. miesza sie dokladnie. Mieszanine ugniata sie z 120 cz. wag. sluzu tragantowego i 50 cz. wag. wody na mase plastyczna. Z tej ostatniej wytla¬ cza sie, w sposób znany zapomoca odpo¬ wiedniej prasy, pastylki o okreslonej dlu¬ gosci i grubosci.Pastylki rzeczone sa sprezyste i pomi¬ mo to posiadaja wytrzymalosc dostatecz¬ na. Rozpuszczaja sie szybko i calkowicie w wodzie i skladnik czynny, jak wykaza¬ ly próby bakterjologiczne, przechodzi z latwoscia do otaczajacego pastylki osrod¬ ka np, do plytki agarowej. PL PLPellets, pills and similar medicinal products are manufactured according to a variety of recipes, depending on their intended use. Pellets and similar medicinal products are made either from a basic mass of e.g. cocoa butter and a related medicament, or Glycerin gelatin, then the main mass may consist of dextrin, sugar, starch, glycerin and active body, and finally pellets are also made by compressing the medicament and the starch-containing mixture. However, said pellets have various disadvantages. Cocoa butter lozenges melt too easily, and glycerin gelatin lozenges are pliable and have insufficient strength. It has now been found that lozenges and similar products which contain by weight in addition to the relevant active agent and, for example, a small amount of Suce . Liauir, further one or more hydrotropic agents suitable for this purpose, e.g. sodium p-toluolsulfonate or sodium sulfonate as such or mixed with inert, easily dissolving bodies, e.g. borax or milk sugar, and the articles by kneading the mixture of the above with water and a small amount of mucilage, they become elastic, they do not show the drawbacks mentioned above. For example, the procedure is as follows: 100 parts by weight of protargol, 430 parts wt. sodium p-toluolsulfonate, 284 p. wt. borax and 16 parts wt. Bitch. Liauir. mixed thoroughly. The mixture is kneaded with 120 parts. wt. tragant mucus and 50 parts wt. water for plastic mass. From the latter, pellets of a certain length and thickness are extruded in a manner known per se with the aid of a suitable press. Said pellets are elastic and, in spite of this, have sufficient strength. They dissolve rapidly and completely in water and the active ingredient, as demonstrated by bacteriological tests, passes easily into the medium surrounding the pellets, for example into an agar plate. PL PL

Claims (1)

1. Zastrzezenie patentowe. Sposób wytwarzania ze srodków lecz¬ niczych sprezystych, latworozpuszczaja- cych sie wyrobów, jak pastylek, pigulek i podobnych wyrobów leczniczych, zna¬ mienny tern, ze jako mase zasadnicza do tych wyrobów stosuje sie srodki hydro- tropowe, np. p-toluolosulfonian sodowy lub sulfaniljan sodowy, jako takie, lub zmie¬ szane z innemi rozpuszczajacemi sie w wo¬ dzie cialami. I. G. Farbenindustrie Aktiengesellschaft. Zastepca: M. Skrzypkowski, rzecznik patentowy. Druk L. Boguslawskiego, Warszawa. PL PL1. Patent claim. A method of producing elastic medicaments, easily dissolving products such as lozenges, pills and similar medicinal products, characterized by the fact that hydrotropic agents, for example sodium p-toluolsulfonate or sodium sulfanilate, as is or mixed with other water-soluble bodies. I. G. Farbenindustrie Aktiengesellschaft. Deputy: M. Skrzypkowski, patent attorney. Printed by L. Boguslawski, Warsaw. PL PL
PL8792A 1927-03-15 A method of producing elastic, easily dissolving lozenges, pills, medicinal products. PL8792B1 (en)

Publications (1)

Publication Number Publication Date
PL8792B1 true PL8792B1 (en) 1928-05-31

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