PL820B1 - Method for the purification of amino aryl arsinic acids. - Google Patents
Method for the purification of amino aryl arsinic acids. Download PDFInfo
- Publication number
- PL820B1 PL820B1 PL820A PL82021A PL820B1 PL 820 B1 PL820 B1 PL 820B1 PL 820 A PL820 A PL 820A PL 82021 A PL82021 A PL 82021A PL 820 B1 PL820 B1 PL 820B1
- Authority
- PL
- Poland
- Prior art keywords
- purification
- acid
- acids
- amino aryl
- arsinic acids
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- 238000000746 purification Methods 0.000 title claims 2
- -1 amino aryl arsinic acids Chemical class 0.000 title description 3
- 239000002253 acid Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 claims description 4
- 230000008025 crystallization Effects 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- DJHGAFSJWGLOIV-UHFFFAOYSA-N Arsenic acid Chemical compound O[As](O)(O)=O DJHGAFSJWGLOIV-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229940000488 arsenic acid Drugs 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Description
Wiadomem jest, ze kwas p-aminpfenylo- arsiinowy, produkt cenny jako wyjsciowy dla fabrykacji zwiazków aryloairsinowych, otrzymuje sie bez wzgledu na modyfikacje zasadniczej metody wydobywania- go z ani¬ liny i kwasu arsioowogo, w stanie powaznie zalnfeczysziczonyim zwiazkami piokrewnemi, a w szczególnosci kwasem dwuaminodwufe- nyloarsinowym, którego domieszka ze wzgledów terapeutycznych jest nader szko- . dliwa. Wiadomo równiez, ze mieiszainiinar obu wspomnianych kwasów daje sie roizdzielic przez krystalizacje ich soli sodowych z.'alko¬ holu; stosowanie jednak tego sposobu przy fabrykacji na wieksza skale napotyka na powazne trudnosci jak znaczne koszta, nie¬ bezpieczenstwo pozaru i inne.Obecnie znaleziono, ze sole potasowców w szczególnosci jednoz&jsadowe obu pomie- nionych kwasów daja sie skutecznie roz¬ dzielic przez krystalizacje czastkowa z wo^ dy, a otrzymywana w rezultacie sól kw,asu aminofenylloansinowego jest 100°/0-ej czy¬ stosci. Metoda ta daje! sie przyteim uogólnic, gdyz rozszerza sie na zwiazki homologiczne. t Przyklad. 217 kg surowego kwasu p-aminofenylo- arsinowego z zaJwairtosciia, np. 10—20% kwia1- su dwuaminodwufenyloarsiriowego, rozpu¬ szcza sie w 100 1 wody z dodainiiem 10 1 lugu sodowego 36° Be, goitujac bezposrednio para wodlna. Po ostudzeniu wykrysitailizowu- je w pieknych wielkich krysztalach sól jed- :nosodowa kwasu p-aminofenyloarsinowego.Krysztaly, wysuszone przy zwyklej tern- wyodrebnic przez dal&za krystalizacje ozast- peraturze, zawieraja cztery czasteczki wody. kowa.Analitycznie po za tern stwierdzono teo- „ . . . . , ,, PL PLIt is known that p-aminophenyl arsiic acid, a valuable starting product for the production of arylamine compounds, is obtained regardless of the modification of the basic method of extracting from angina and arsenic acid, in a state that is severely treated with pyrogenic compounds, and in particular with diamine acid. - nyloarsine, the admixture of which, due to therapeutic reasons, is very high school. dliwa. It is also known that the mixture of the two acids mentioned can be separated by crystallization of their sodium salts from alcohol; however, the application of this method in large-scale fabrication is faced with serious difficulties, such as considerable costs, risk of fire and others. It has now been found that, in particular, monosolamic salts of both mentioned acids can be effectively separated by partial crystallization from water The result is that the resultant aminophenylacinic acid salt is 100% pure. This method gives you! it is to be generalized because it extends to homologous compounds. t Example. 217 kg of crude p-aminophenyl arsinic acid, eg 10-20% diamino diphenyl arsiric acid, are dissolved in 100 liters of water with 10 liters of sodium hydroxide solution 36 ° Be, directly calming water vapor. After cooling, it detected in beautiful large crystals the monosodium salt of p-aminophenylacic acid. The crystals, dried by simple isolation by further crystallization in nature, contain four water molecules. Kowa. Analytically, it was stated that theo- “. . . . , ,, PL PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL820B1 true PL820B1 (en) | 1924-11-29 |
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