PL67865B1 - - Google Patents
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- Publication number
- PL67865B1 PL67865B1 PL145558A PL14555867A PL67865B1 PL 67865 B1 PL67865 B1 PL 67865B1 PL 145558 A PL145558 A PL 145558A PL 14555867 A PL14555867 A PL 14555867A PL 67865 B1 PL67865 B1 PL 67865B1
- Authority
- PL
- Poland
- Prior art keywords
- solution
- ester
- decanoyl
- dimethylformamide
- quinolyl
- Prior art date
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- -1 N-decanoyl amino Chemical class 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- HQQZYKLJMWIKOD-UHFFFAOYSA-N 2-[[2-(decanoylamino)acetyl]amino]acetic acid Chemical compound CCCCCCCCCC(=O)NCC(=O)NCC(O)=O HQQZYKLJMWIKOD-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Description
Warstwe wodna po odsaczeniu osadu wyekstrahowano kilkakrotnie octanem etylu. Po wysuszeniu i odparowaniu octa¬ nu otrzymano 850 mg zwiazku, identycznego z po¬ przednio odsaczonym osadem. W sumie otrzymano 1,50 g N-dekanoilo-glicylo-glicyny (53% wydajnosci) %N obliczony = 9,80 25 Dla C14H2e04N2 (M = 286,4) %N znaleziony = 987 Przyklad IV. Do roztworu 1,16 g (3,8 mM) bromowodorku glicylo-L-fenyloalaniny w 7,6 ml In NaOH (7,6 mM) dodano roztwór 1,53 g (5,3 mM) estru chinolyl-8-owego kwasu dekanowego (otrzy¬ manego w sposób opisany w przykladzie II) w 6 ml dwumetyloformamidu. Mieszanine reakcyjna, w której byly dwie warstwy, wytrzasano 1 godzi¬ ne i 15 minut w temperaturze 20°C. Po skonczonej reakcji postepowano analogicznie, jak w przykla¬ dzie I i II. Otrzymano 960 mg (82% wydajnosci) N-dekanoilo-glicylo-L-fenyloalaniny w formie ge¬ stego oleju.%N obliczony = 7,45 Dla C21H3204N2 (M = 376,5) 0/oN znaieziony = 7,35 PL PL
Claims (1)
1. Zastrzezenie patentowe Sposób wytwarzania N-dekanoilo-aminokwasów i -peptydów, znamienny tym, ze na roztwór wod¬ ny soli sodowej lub potasowej aminokwasu lub peptydu dziala sie roztworem estru pirydyl-3-owe- go lub chinolyl-8-owego kwasu dekanowego w dwumetyloformamidzie. 30 W.D.Kart. C/325/73, 100+15, A4 Cena zl 10.— PL PL
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL67865B1 true PL67865B1 (pl) | 1972-12-30 |
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