PL63002B1 - - Google Patents
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- Publication number
- PL63002B1 PL63002B1 PL122906A PL12290667A PL63002B1 PL 63002 B1 PL63002 B1 PL 63002B1 PL 122906 A PL122906 A PL 122906A PL 12290667 A PL12290667 A PL 12290667A PL 63002 B1 PL63002 B1 PL 63002B1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- general formula
- mor
- reactions
- catalyst
- Prior art date
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 101100276977 Caenorhabditis elegans dapk-1 gene Proteins 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 150000005171 halobenzenes Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- QMBFJLTXYWWQIQ-UHFFFAOYSA-N 2-[2-(2,3-dimethylanilino)phenyl]acetic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)CC(O)=O)=C1C QMBFJLTXYWWQIQ-UHFFFAOYSA-N 0.000 description 1
- AWNWLZIGTUDXIU-UHFFFAOYSA-N 2-[2-[2-chloro-5-(trifluoromethyl)anilino]phenyl]acetic acid Chemical compound ClC1=C(NC2=C(C=CC=C2)CC(=O)O)C=C(C=C1)C(F)(F)F AWNWLZIGTUDXIU-UHFFFAOYSA-N 0.000 description 1
- YRLCJTLJODVGRC-UHFFFAOYSA-N COC1=CC=C(C=C1C)NC1=C(C=CC=C1)CC(=O)O Chemical compound COC1=CC=C(C=C1C)NC1=C(C=CC=C1)CC(=O)O YRLCJTLJODVGRC-UHFFFAOYSA-N 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
Description
W analogiczny sposób jak w powyzszych przy¬ kladach mozna wytworzyc nastepujace kwasy fe- nylooctowe: kwas [o-(2,3-ksylidyno)fenylo]-octowy o tempera¬ turze topnienia 112°C; kwas [o-(3-trójfluorometylo-6-chloroanilino)-fe- nylo]-octowy o temperaturze topnienia 94—96°; kwas [o-(6-metoksy-m-toluidyno)-fenylo]-octowy o temperaturze topnienia 105—107°. PL PL
Claims (3)
1. Zastrzezenia patentowe 1. Sposób wytwarzania podstawionych kwasów fenylooctowyeh o wzorze ogólnym 1, w którym Ri oznacza nizsza grupe alkilowa, atom chlorowca do liczby atomowej 17 lub grupe trójfiuorometyIowa, R2 oznacza wodór lub podstawnik o znaczeniu poda¬ nym dla Ri, R3 oznacza wodór, nizsza grupe alki¬ lowa lub alkoksylowa albo atom chlorowca do liczby atomowej' 17, znamienny tym, ze zwiazek o wzorze ogólnym 2 poddaje sie reakcji z podsta¬ wionym chlorowcobenzenem o wzorze ogólnym 3, w którym Hal oznacza brom lub jod, a Ri, R2 i R3 maja wyzej podane znaczenie, w obecnosci srodka wiazacego kwas i ewentualnie katalizatora przy¬ spieszajacego wymiane chlorowca zwiazanego z pierscieniem aromatycznym.
2. Sposób wedlug zastrz. 1, znamienny tym, ze reakcje prowadzi sie w obecnosci sproszkowanej miedzi jako katalizatora.
3. Sposób wedlug zastrz. 1, znamienny tym, ze reakcje prowadzi sie w nadmiarze zwiazku o wzo¬ rze 3, w którym Ri, R2 i R3 maja znaczenie podane w zastrz. 1, w temperaturze wrzenia tego zwiazku. Dokonano jednej poprawki ^:m?/iiKI. 12 o, 11 63002 MKP C 07 c, 63/54 (^V"CH2—CO-OH NH ^ 8* N H mór 2 mor 3 PL PL
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL63002B1 true PL63002B1 (pl) | 1971-04-30 |
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