PL57565B1 - - Google Patents
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- Publication number
- PL57565B1 PL57565B1 PL115299A PL11529966A PL57565B1 PL 57565 B1 PL57565 B1 PL 57565B1 PL 115299 A PL115299 A PL 115299A PL 11529966 A PL11529966 A PL 11529966A PL 57565 B1 PL57565 B1 PL 57565B1
- Authority
- PL
- Poland
- Prior art keywords
- brevibacterium
- microorganism
- compounds
- derivatives
- microorganisms
- Prior art date
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- 238000000034 method Methods 0.000 claims 7
- 244000005700 microbiome Species 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000006356 dehydrogenation reaction Methods 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 241000186146 Brevibacterium Species 0.000 claims 1
- 241000218649 Brevibacterium fuscum Species 0.000 claims 1
- 241001518266 Corynebacterium vitaeruminis Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241001524175 Glutamicibacter protophormiae Species 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Description
Otrzymana mase suszy sie pod zmniejszonym cisnieniem, po czym rozpuszcza w 6 metanolu. Roztwór metanolowy odbarwia sie we¬ glem aktywnym. Po przesaczeniu odbarwionego roztworu metanol odparowuje sie, oziebia do +4°C w ciagu 10 godzin. Wykrystalizowuje osad, który 5 odsacza sie i suszy pod zmniejszonym cisnieniem.Po wysuszeniu produkt ten posiada cechy cha- ' rakterystyczne dla pregnadienu-l,4-3,20-dionu. « PL
Claims (4)
- Zastrzezenia patentowe io 1. Sposób wytwarzania pochodnych 3-keto-All4- pregnadienu na drodze mikrobiologicznej dehy¬ drogenacji sterydów znamienny tym, ze preg- nen-4,17 alfa-21-diol-3,ll,20-trion, pregnen-4,11 15 beta, 17 alfa, 21-triol-3,20-dion, lub halogeno- -pochodne tych zwiazków, lub hydroksy-po- chodne tych zwiazków zawierajace grupy hy¬ droksylowe w innych pozycjach, albo estry 21 tych zwiazków poddaje sie dehydrogenacji w 20 pozycji 1 za pomoca kultury mikroorganizmów rodzaju Brevibacterium lub enzymów produ¬ kowanych przez te drobne ustroje.
- 2. Sposób wedlug zastrz. 1 znamienny tym, ze jako mikroorganizm stosuje sie Brevibacterium 25 protophormiae.
- 3. Sposób wedlug zastrz. 1 znamienny tym, ze jako mikroorganizm stosuje sie Brevibacterium fuscum.
- 4. Sposób wedlug zastrz. 1 znamienny tym, ze 30 jako mikroorganizm stosuje sie Brevibacterium vitarumen. PL
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL57565B1 true PL57565B1 (pl) | 1969-04-28 |
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