PL448318A1 - Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki - Google Patents

Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki

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Publication number
PL448318A1
PL448318A1 PL448318A PL44831824A PL448318A1 PL 448318 A1 PL448318 A1 PL 448318A1 PL 448318 A PL448318 A PL 448318A PL 44831824 A PL44831824 A PL 44831824A PL 448318 A1 PL448318 A1 PL 448318A1
Authority
PL
Poland
Prior art keywords
spock2
regulator
application
cells
pluripotent stem
Prior art date
Application number
PL448318A
Other languages
English (en)
Other versions
PL248682B1 (pl
Inventor
Małgorzata BOROWIAK
Katarzyna BŁASZCZYK
Anna Paulina JĘDRZEJAK
Original Assignee
Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Im. Adama Mickiewicza W Poznaniu filed Critical Uniwersytet Im. Adama Mickiewicza W Poznaniu
Priority to PL448318A priority Critical patent/PL248682B1/pl
Priority to PCT/IB2025/054020 priority patent/WO2025219915A1/en
Publication of PL448318A1 publication Critical patent/PL448318A1/pl
Publication of PL248682B1 publication Critical patent/PL248682B1/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Przedmiotem zgłoszenia jest zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek trzustki.
PL448318A 2024-04-16 2024-04-16 Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki PL248682B1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL448318A PL248682B1 (pl) 2024-04-16 2024-04-16 Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki
PCT/IB2025/054020 WO2025219915A1 (en) 2024-04-16 2025-04-16 USE OF SP0CK2 AS A REGULATOR OF DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TOWARDS PANCREATIC β-CELLS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL448318A PL248682B1 (pl) 2024-04-16 2024-04-16 Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki

Publications (2)

Publication Number Publication Date
PL448318A1 true PL448318A1 (pl) 2025-10-20
PL248682B1 PL248682B1 (pl) 2026-01-12

Family

ID=95937568

Family Applications (1)

Application Number Title Priority Date Filing Date
PL448318A PL248682B1 (pl) 2024-04-16 2024-04-16 Zastosowanie SPOCK2, jako regulatora różnicowania ludzkich pluripotencjalnych komórek macierzystych w kierunku komórek β trzustki

Country Status (2)

Country Link
PL (1) PL248682B1 (pl)
WO (1) WO2025219915A1 (pl)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140329704A1 (en) * 2013-03-28 2014-11-06 President And Fellows Of Harvard College Markers for mature beta-cells and methods of using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BYRNES, L. E. I IN.: "Nat. Commun. 9, 3922, 2018", LINEAGE DYNAMICS OF MURINE PANCREATIC DEVELOPMENT AT SINGLE CELL RESOLUTION., DOI: 10.1038/s41467-018-06176-3 *
SCAVUZZO, M. A. I IN.: "Nat. Commun. 9, 3356, 2018", ENDOCRINE LINEAGE BIASES ARISE IN TEMPORALLY DISTINCT ENDOCRINE PROGENITORS DURING PANCREATIC MORPHOGENESIS, DOI: 10.1038/s41467-018-05740-1; *
WENWEN JIN, WEI JIANG,: "Cell Regeneration, 2022, 11:24,", STEPWISE DIFFERENTIATION OF FUNCTIONAL PANCREATIC Β CELLS FROM HUMAN PLURIPOTENT STEM CELLS, DOI: https://doi.org/10.1186/s13619-022-00125-8; *

Also Published As

Publication number Publication date
PL248682B1 (pl) 2026-01-12
WO2025219915A1 (en) 2025-10-23

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