PL447324A1 - Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywania - Google Patents
Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywaniaInfo
- Publication number
- PL447324A1 PL447324A1 PL447324A PL44732422A PL447324A1 PL 447324 A1 PL447324 A1 PL 447324A1 PL 447324 A PL447324 A PL 447324A PL 44732422 A PL44732422 A PL 44732422A PL 447324 A1 PL447324 A1 PL 447324A1
- Authority
- PL
- Poland
- Prior art keywords
- sup
- cation
- weight
- reaction
- synthetic bioactive
- Prior art date
Links
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical class [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract 6
- 230000000975 bioactive effect Effects 0.000 title abstract 4
- 239000000463 material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 150000001768 cations Chemical class 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 239000011777 magnesium Substances 0.000 abstract 5
- 239000011701 zinc Substances 0.000 abstract 5
- 239000011575 calcium Substances 0.000 abstract 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 229910052712 strontium Inorganic materials 0.000 abstract 2
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- 239000002019 doping agent Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B28—WORKING CEMENT, CLAY, OR STONE
- B28B—SHAPING CLAY OR OTHER CERAMIC COMPOSITIONS; SHAPING SLAG; SHAPING MIXTURES CONTAINING CEMENTITIOUS MATERIAL, e.g. PLASTER
- B28B11/00—Apparatus or processes for treating or working the shaped or preshaped articles
- B28B11/04—Apparatus or processes for treating or working the shaped or preshaped articles for coating or applying engobing layers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Ceramic Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Structural Engineering (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywania. Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany, w postaci cząstek nanometrycznych, zawiera wapń Ca w ilości 38,97 do 39,81% wag. oraz fosfor P w ilości 18,39 do 18,57% wag. związane w nanokrystaliczny hydroksyapatyt HAP domieszkowany, a domieszka zawiera co najmniej jeden metal wybrany spośród magnezu Mg albo strontu Sr albo cynku Zn, wprowadzony w postaci kationu Mg<sup>2+</sup> albo kationu Sr<sup>2+</sup> albo kationu Zn<sup>2+</sup>, gdzie zawartość strontu wynosi od 0,09 do 1,3% wag., zawartość cynku wynosi od 0,06 do 0,97% wag., zawartość magnezu wynosi od 0,02 do 0,36% wag. Natomiast sposób otrzymywania syntetycznego bioaktywnego materiału hydroksyapatytowego domieszkowanego metodą chemiczną na mokro, gdzie w alkalicznych warunkach reakcji syntezy z roztworu reakcyjnego, zawierającego źródło wielu jonów, w tym jony Ca<sup>2+</sup> oraz metalu wprowadzonego w postaci kationu Mg<sup>2+</sup> albo kationu Sr<sup>2+</sup> albo kationu Zn<sup>2+</sup>, wytrąca się w postaci osadu związki zawierające fosfor i wapń. Reakcję prowadzi się w zakresie temperatur od 25°C do 65°C w czasie od 2 do 12 godzin, przy pH roztworu o wartości od 9 do 11. Do roztworu reakcyjnego dozuje się roztwór wodny zawierający jony fosforanowe PO<sub>4</sub><sup>3-</sup>, i utrzymuje stan równowagi substratów, aż do wyczerpania i wytrącenia osadu z nanometrycznej wielkości cząstkami krystalicznymi hydroksyapatytu z domieszką. Osad oczyszcza się przez wielokrotne odwirowanie z prędkością od 3500 do 4000 rpm w czasie 2 do 5 min przemiennie z przemywaniem wodą dejonizowaną do uzyskania odczynu obojętnego, i poddaje suszeniu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL447324A PL447324A1 (pl) | 2022-10-06 | 2022-10-06 | Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL447324A PL447324A1 (pl) | 2022-10-06 | 2022-10-06 | Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywania |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL447324A1 true PL447324A1 (pl) | 2024-05-13 |
Family
ID=91070380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL447324A PL447324A1 (pl) | 2022-10-06 | 2022-10-06 | Syntetyczny bioaktywny materiał hydroksyapatytowy modyfikowany oraz sposób jego otrzymywania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL447324A1 (pl) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090276056A1 (en) * | 2006-04-25 | 2009-11-05 | Washington State University | Resorbable ceramics with controlled strength loss rates |
| WO2012024634A2 (en) * | 2010-08-19 | 2012-02-23 | University Of Washington Through Its Center For Commercialization | Environmentally-responsive nanocomposites and methods of their use |
-
2022
- 2022-10-06 PL PL447324A patent/PL447324A1/pl unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090276056A1 (en) * | 2006-04-25 | 2009-11-05 | Washington State University | Resorbable ceramics with controlled strength loss rates |
| WO2012024634A2 (en) * | 2010-08-19 | 2012-02-23 | University Of Washington Through Its Center For Commercialization | Environmentally-responsive nanocomposites and methods of their use |
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