PL444478A1 - Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining - Google Patents

Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining

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Publication number
PL444478A1
PL444478A1 PL444478A PL44447823A PL444478A1 PL 444478 A1 PL444478 A1 PL 444478A1 PL 444478 A PL444478 A PL 444478A PL 44447823 A PL44447823 A PL 44447823A PL 444478 A1 PL444478 A1 PL 444478A1
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Poland
Prior art keywords
tau
biosensor
surface plasmon
plasmon resonance
protein
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PL444478A
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English (en)
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PL247217B1 (pl
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Łukasz Ołdak
Ewa Gorodkiewicz
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Uniwersytet W Białymstoku
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Priority to PL444478A priority Critical patent/PL247217B1/pl
Publication of PL444478A1 publication Critical patent/PL444478A1/pl
Publication of PL247217B1 publication Critical patent/PL247217B1/pl

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Przedmiotem zgłoszenia jest biosensor do specyficznego oznaczania p-Tau 181 w płynach ustrojowych w płynach ustrojowych i homogenatach tkankowych techniką matrycowego powierzchniowego rezonansu plazmonów w wersji Imaging, który zawiera płytkę szklaną (1) podzieloną na partycje za pomocą siatki polimerowej (4) i pokrytą warstwą złota (3) na podłożu tytanu (2) oraz siatkę polimeru tworzącą pęk miejsc aktywnych zawierających warstwę receptorową. Warstwę receptorową stanowi monoklonalne królicze przeciwciało specyficzne na fosforylowane białko Tau (p-Tau 181) jako ligand (6) połączone kowalencyjnie z linkerem, w postaci cysteaminy (5), łączącym receptor z warstwą złota (3) na podłożu tytanu (2) pokrywających płytkę szklaną (1).
PL444478A 2023-04-19 2023-04-19 Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining PL247217B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL444478A PL247217B1 (pl) 2023-04-19 2023-04-19 Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL444478A PL247217B1 (pl) 2023-04-19 2023-04-19 Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining

Publications (2)

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PL444478A1 true PL444478A1 (pl) 2024-10-21
PL247217B1 PL247217B1 (pl) 2025-06-02

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PL444478A PL247217B1 (pl) 2023-04-19 2023-04-19 Biosensor do specyficznego oznaczania białka fosfo-Tau p181 z wykorzystaniem techniki powierzchniowego rezonansu plazmonów w wersji obrazowej Imagining

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL430495A1 (pl) * 2019-07-04 2021-01-11 Politechnika Poznańska Biosensor do specyficznego oznaczania stężenia katepsyny S w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging
PL432021A1 (pl) * 2019-11-29 2021-05-31 Politechnika Poznańska Biosensor do specyficznego oznaczania stężenia ludzkiego antygenu rakowo-płodowego CEA
PL433106A1 (pl) * 2020-03-02 2021-09-06 Politechnika Poznańska Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL430495A1 (pl) * 2019-07-04 2021-01-11 Politechnika Poznańska Biosensor do specyficznego oznaczania stężenia katepsyny S w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging
PL432021A1 (pl) * 2019-11-29 2021-05-31 Politechnika Poznańska Biosensor do specyficznego oznaczania stężenia ludzkiego antygenu rakowo-płodowego CEA
PL433106A1 (pl) * 2020-03-02 2021-09-06 Politechnika Poznańska Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
S. SHEKHAR ET AL.: "PLoS One. 2016 Jul 26;11(7):e0159099", ESTIMATION OF TAU AND PHOSPHORYLATED TAU181 IN SERUM OF ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT PATIENTS. *

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