PL442759A1 - Diazowe pochodne kolchicyny oraz sposób ich otrzymywania - Google Patents

Diazowe pochodne kolchicyny oraz sposób ich otrzymywania

Info

Publication number
PL442759A1
PL442759A1 PL442759A PL44275922A PL442759A1 PL 442759 A1 PL442759 A1 PL 442759A1 PL 442759 A PL442759 A PL 442759A PL 44275922 A PL44275922 A PL 44275922A PL 442759 A1 PL442759 A1 PL 442759A1
Authority
PL
Poland
Prior art keywords
colchicine
sub
diazo
formula
derivatives
Prior art date
Application number
PL442759A
Other languages
English (en)
Inventor
Hanna Krawczyk
Filip Borys
Original Assignee
Politechnika Warszawska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Warszawska filed Critical Politechnika Warszawska
Priority to PL442759A priority Critical patent/PL442759A1/pl
Publication of PL442759A1 publication Critical patent/PL442759A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia są diazowe pochodne kolchicyny o wzorze ogólnym (1), w których R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub> niezależnie oznaczają H lub F, przy czym fragment diazowy łączy się z pierścieniem benzamidowym w pozycjach orto, meta lub para. Kolejnym przedmiotem zgłoszenia jest sposób otrzymywania diazowych pochodnych kolchicyny obejmujący reakcję kolchicyny o wzorze ogólnym (2) z pochodną diazową o wzorze (3), a także sposób otrzymywania diazowych pochodnych kolchicyny obejmujący etap syntezy pochodnej diazowej o wzorze (3) w reakcji chlorku kwasowego o wzorze (4) z nitrozobenzenem o wzorze (5).
PL442759A 2022-11-08 2022-11-08 Diazowe pochodne kolchicyny oraz sposób ich otrzymywania PL442759A1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL442759A PL442759A1 (pl) 2022-11-08 2022-11-08 Diazowe pochodne kolchicyny oraz sposób ich otrzymywania

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL442759A PL442759A1 (pl) 2022-11-08 2022-11-08 Diazowe pochodne kolchicyny oraz sposób ich otrzymywania

Publications (1)

Publication Number Publication Date
PL442759A1 true PL442759A1 (pl) 2024-05-13

Family

ID=91070351

Family Applications (1)

Application Number Title Priority Date Filing Date
PL442759A PL442759A1 (pl) 2022-11-08 2022-11-08 Diazowe pochodne kolchicyny oraz sposób ich otrzymywania

Country Status (1)

Country Link
PL (1) PL442759A1 (pl)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035865A2 (en) * 1998-12-17 2000-06-22 Tularik Inc. Tubulin-binding agents
CN103553957A (zh) * 2013-09-27 2014-02-05 华东师范大学 含有组蛋白去乙酰化酶抑制活性的秋水仙碱衍生物及制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035865A2 (en) * 1998-12-17 2000-06-22 Tularik Inc. Tubulin-binding agents
CN103553957A (zh) * 2013-09-27 2014-02-05 华东师范大学 含有组蛋白去乙酰化酶抑制活性的秋水仙碱衍生物及制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MÜLLER-DEKU, A.; MEIRING, J.C.M.; LOY, K.; KRAUS, Y.; HEISE, C.; BINGHAM, R.; JANSEN, K.I.; QU, X.; BARTOLINI, F.; KAPITEIN, L.C., PHOTOSWITCHABLE PACLITAXEL-BASED MICROTUBULE STABILISERS ALLOW OPTICAL CONTROL OVER THE MICROTUBULE CYTOSKELETON. NAT. COMMUN. 2020, 11, 4640. *

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