PL442527A1 - Sposób otrzymywania seskwiterpenów - pochodnych petazyny z kłączy lepiężnika różowego (Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb.) - Google Patents
Sposób otrzymywania seskwiterpenów - pochodnych petazyny z kłączy lepiężnika różowego (Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb.)Info
- Publication number
- PL442527A1 PL442527A1 PL442527A PL44252722A PL442527A1 PL 442527 A1 PL442527 A1 PL 442527A1 PL 442527 A PL442527 A PL 442527A PL 44252722 A PL44252722 A PL 44252722A PL 442527 A1 PL442527 A1 PL 442527A1
- Authority
- PL
- Poland
- Prior art keywords
- petazine
- sesquiterpenes
- derivatives
- butterbur
- rhizomes
- Prior art date
Links
- 229930004725 sesquiterpene Natural products 0.000 title abstract 6
- 150000004354 sesquiterpene derivatives Chemical class 0.000 title abstract 6
- 241000485481 Petasites hybridus Species 0.000 title abstract 4
- 235000001436 butterbur Nutrition 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 235000003823 Petasites japonicus Nutrition 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 238000002953 preparative HPLC Methods 0.000 abstract 3
- 238000004810 partition chromatography Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- YSVZGWAJIHWNQK-UHFFFAOYSA-N [3-(hydroxymethyl)-2-bicyclo[2.2.1]heptanyl]methanol Chemical compound C1CC2C(CO)C(CO)C1C2 YSVZGWAJIHWNQK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/30—Partition chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Zgłoszenie rozwiązuje zagadnienie izolacji seskwiterpenów, pochodnych petazyny, przy zastosowaniu techniki odśrodkowej chromatografii podziałowej (centrifugal partition chromatography, CPC) oraz preparatywnej wysokosprawnej chromatografii cieczowej (preparative high performance liquid chromatography, prepHPLC). Przedmiotem zgłoszenia jest sposób otrzymywania seskwiterpenów, pochodnych petazyny z kłączy lepiężnika różowego (Petasites hybridus (L.), który charakteryzuje się tym, że suchy ekstrakt poddaje się rozdzielaniu przy użyciu odśrodkowej chromatografii podziałowej z dwufazową mieszaniną rozpuszczalników o składzie heksan, metanol, woda. Separację przeprowadza się w trybie zstępującym, a rotację kolumny podczas eksperymentów doprowadza się do maksymalnej liczby obrotów, zaś rozdzielanie prowadzi się w temperaturze 25°C – 35°C, a stężenie nastrzykiwanego ekstraktu wynosi od 25 do 50 mg/ml, natomiast frakcje zawierające seskwiterpeny (pochodne petazyny) zbierane są pod kontrolą detektora UV-VIS, a seskwiterpeny, pochodne petazyny izoluje się, a uzyskane frakcje poddaje się oczyszczeniu, a w pierwszym etapie frakcje uzyskane metodą CPC zawierające odpowiednie seskwiterpeny, (pochodne petazyn) odparowuje się do sucha i rozpuszcza w metanolu, a uzyskany roztwór poddaje się oczyszczeniu przy użyciu preparatywnej wysokosprawnej chromatografii cieczowej.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442527A PL245499B1 (pl) | 2022-10-14 | 2022-10-14 | Sposób otrzymywania seskwiterpenów-pochodnych petazyny z kłączy lepiężnika różowego Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442527A PL245499B1 (pl) | 2022-10-14 | 2022-10-14 | Sposób otrzymywania seskwiterpenów-pochodnych petazyny z kłączy lepiężnika różowego Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL442527A1 true PL442527A1 (pl) | 2024-04-15 |
| PL245499B1 PL245499B1 (pl) | 2024-08-12 |
Family
ID=90716770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL442527A PL245499B1 (pl) | 2022-10-14 | 2022-10-14 | Sposób otrzymywania seskwiterpenów-pochodnych petazyny z kłączy lepiężnika różowego Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb. |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL245499B1 (pl) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL122936B1 (en) * | 1978-08-18 | 1982-09-30 | Inst Przemyslu Fermentacyjnego | Method of preparing of extracts from vegetable raw-materials containing chamazulene and sesquiterpene and flavonoid compounds |
| DE19702168A1 (de) * | 1996-03-28 | 1997-10-02 | Zeller Max Soehne Ag | Verwendung von Extrakt aus Petasites hybridus sowie Verfahren und Vorrichtung zur Gewinnung des Extraktes |
-
2022
- 2022-10-14 PL PL442527A patent/PL245499B1/pl unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL122936B1 (en) * | 1978-08-18 | 1982-09-30 | Inst Przemyslu Fermentacyjnego | Method of preparing of extracts from vegetable raw-materials containing chamazulene and sesquiterpene and flavonoid compounds |
| DE19702168A1 (de) * | 1996-03-28 | 1997-10-02 | Zeller Max Soehne Ag | Verwendung von Extrakt aus Petasites hybridus sowie Verfahren und Vorrichtung zur Gewinnung des Extraktes |
Non-Patent Citations (1)
| Title |
|---|
| PETER SIEGENTHALER; MARKUS NEUENSCHWANDER: "Pharmaceutica Acta Helvetiae; Volume 72, Issue 2, April 1997, Pages 57-67", SESQUITERPENES FROM PETASITES HYBRIDUS (FURANOPETASIN CHEMOVAR): SEPARATION, ISOLATION AND QUANTITATION OF COMPOUNDS FROM FRESH PLANT EXTRACTS * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL245499B1 (pl) | 2024-08-12 |
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