PL442461A1 - Synthetic bioactive hydroxyapatite material and method of its preparation - Google Patents
Synthetic bioactive hydroxyapatite material and method of its preparationInfo
- Publication number
- PL442461A1 PL442461A1 PL442461A PL44246122A PL442461A1 PL 442461 A1 PL442461 A1 PL 442461A1 PL 442461 A PL442461 A PL 442461A PL 44246122 A PL44246122 A PL 44246122A PL 442461 A1 PL442461 A1 PL 442461A1
- Authority
- PL
- Poland
- Prior art keywords
- sup
- ions
- reaction
- rpm
- hydroxyapatite
- Prior art date
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 title abstract 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract 5
- 239000000463 material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000000975 bioactive effect Effects 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 239000011575 calcium Substances 0.000 abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 3
- 150000002500 ions Chemical class 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- 239000002019 doping agent Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 125000004437 phosphorous atom Chemical group 0.000 abstract 1
- 239000013049 sediment Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest syntetyczny bioaktywny materiał hydroksyapatytowy, w postaci cząstek nanometrycznych, który zawiera wapń Ca w ilości 39,84% wag. oraz fosfor P w ilości 18,53% wag. związane w nanokrystaliczny hydroksyapatyt HAP, a nanometryczne cząstki o kulistej morfologii mają wielkość w zakresie od 36,50 nm do 49,5 nm. Ponadto materiał hydroksyapatytowy zawiera domieszkę co najmniej jednego spośród jonów Mg<sup>2+</sup>, Zn<sup>2+</sup>, Sr<sup>2+</sup> z zachowaniem stosunku molowego 1,67 dla dwóch i więcej jonów domieszki. Przedmiotem zgłoszenia jest też sposób otrzymywania ww. materiału metodą chemiczną na mokro, który polega na tym, że w alkalicznych warunkach reakcji syntezy, w trakcie mieszania roztworów wodnych substratów z roztworu reakcyjnego, zawierającego źródło wielu jonów, wytrąca się w postaci osadu związki zawierające fosfor i wapń, przy stosunku molowym atomów wapnia do atomów fosforu wynoszącym Ca/P=1,67. Reakcję prowadzi się w zakresie temperatur od 25°C do 65°C w czasie od 2 do 12 godzin, przy pH roztworu o wartości od 9 do 11. W warunkach ciągłego mieszania z szybkością od 450 rpm do 1600 rpm do roztworu reakcyjnego z jonami Ca<sup>2+</sup> dozuje się roztwór wodny zawierający jony fosforanowe PO<sub>4</sub><sup>3-</sup> w czasie 30 - 50 min. Podczas syntezy utrzymuje się stan równowagi substratów, aż do wyczerpania i wytrącenia osadu z nanometrycznej wielkości cząstkami krystalicznymi hydroksyapatytu. Następnie osad oczyszcza się przez wielokrotne odwirowanie z prędkością od 3500 do 4000 rpm w czasie 2 do 5 min przemiennie z przemywaniem wodą dejonizowaną do uzyskania odczynu obojętnego i poddaje suszeniu w czasie od 24 do 72 godzin w temperaturze nie wyższej niż 90°C.The subject of the application is a synthetic bioactive hydroxyapatite material in the form of nanometric particles, which contains calcium Ca in the amount of 39.84% by weight. and phosphorus P in the amount of 18.53% by weight. bound into nanocrystalline hydroxyapatite HAP, and the nanometric particles with spherical morphology have a size ranging from 36.50 nm to 49.5 nm. Moreover, the hydroxyapatite material contains an admixture of at least one of the ions Mg<sup>2+</sup>, Zn<sup>2+</sup>, Sr<sup>2+</sup> with a molar ratio of 1.67 for two or more dopant ions. The subject of the notification is also the method of receiving the above-mentioned. material by the wet chemical method, which consists in the fact that in alkaline reaction conditions of the synthesis, while mixing aqueous solutions of substrates from the reaction solution containing a source of many ions, compounds containing phosphorus and calcium are precipitated in the form of a precipitate, at the molar ratio of calcium atoms to phosphorus atoms amounting to Ca/P = 1.67. The reaction is carried out in the temperature range from 25°C to 65°C for 2 to 12 hours, at a solution pH of 9 to 11. Under continuous stirring at a speed of 450 rpm to 1600 rpm into the reaction solution with Ca ions <sup>2+</sup> an aqueous solution containing PO<sub>4</sub><sup>3-</sup> phosphate ions is dosed within 30 - 50 min. During the synthesis, the equilibrium state of the substrates is maintained until they are exhausted and a precipitate of nanometer-sized crystalline hydroxyapatite particles is formed. Then, the sediment is cleaned by repeated centrifugation at a speed of 3500 to 4000 rpm for 2 to 5 minutes, alternating with washing with deionized water until a neutral reaction is obtained, and dried for 24 to 72 hours at a temperature not higher than 90°C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442461A PL442461A1 (en) | 2022-10-06 | 2022-10-06 | Synthetic bioactive hydroxyapatite material and method of its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442461A PL442461A1 (en) | 2022-10-06 | 2022-10-06 | Synthetic bioactive hydroxyapatite material and method of its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL442461A1 true PL442461A1 (en) | 2024-04-08 |
Family
ID=90623496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL442461A PL442461A1 (en) | 2022-10-06 | 2022-10-06 | Synthetic bioactive hydroxyapatite material and method of its preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL442461A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2776282A1 (en) * | 1998-03-20 | 1999-09-24 | Toulouse Inst Nat Polytech | Surgical or dental hydroxyapatite-based biomaterial preparation |
| WO2000068144A1 (en) * | 1999-05-10 | 2000-11-16 | Abonetics Limited | Method for the preparation of carbonated hydroxyapatite compositions |
-
2022
- 2022-10-06 PL PL442461A patent/PL442461A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2776282A1 (en) * | 1998-03-20 | 1999-09-24 | Toulouse Inst Nat Polytech | Surgical or dental hydroxyapatite-based biomaterial preparation |
| WO2000068144A1 (en) * | 1999-05-10 | 2000-11-16 | Abonetics Limited | Method for the preparation of carbonated hydroxyapatite compositions |
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