PL441982A1 - Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów - Google Patents

Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów

Info

Publication number
PL441982A1
PL441982A1 PL441982A PL44198222A PL441982A1 PL 441982 A1 PL441982 A1 PL 441982A1 PL 441982 A PL441982 A PL 441982A PL 44198222 A PL44198222 A PL 44198222A PL 441982 A1 PL441982 A1 PL 441982A1
Authority
PL
Poland
Prior art keywords
cancer immunotherapy
asymmetrically substituted
biphenyl derivatives
biphenyl
derivatives
Prior art date
Application number
PL441982A
Other languages
English (en)
Inventor
Aleksandra Hec
Jan Barczyński
Urszula Błaszkiewicz
Przemysław Bielski
Michał Mikitiuk
Tomasz SITAR
Tadeusz Holak
Original Assignee
Recepton Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recepton Spółka Z Ograniczoną Odpowiedzialnością filed Critical Recepton Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL441982A priority Critical patent/PL441982A1/pl
Priority to EP22195637.8A priority patent/EP4159720A1/en
Publication of PL441982A1 publication Critical patent/PL441982A1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia są nowe, niesymetrycznie podstawione pochodne 1,1'-bifenylu jako małocząsteczkowe inhibitory celujące w punkt kontroli odpowiedzi immunologicznej PD-1/PD-L1, które mogą znaleźć zastosowanie w immunoterapii nowotworów.
PL441982A 2021-09-30 2022-08-09 Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów PL441982A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL441982A PL441982A1 (pl) 2022-08-09 2022-08-09 Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów
EP22195637.8A EP4159720A1 (en) 2021-09-30 2022-09-14 Nonsymmetric substituted 1,1'-biphenyl derivatives and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441982A PL441982A1 (pl) 2022-08-09 2022-08-09 Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów

Publications (1)

Publication Number Publication Date
PL441982A1 true PL441982A1 (pl) 2024-02-12

Family

ID=89855698

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441982A PL441982A1 (pl) 2021-09-30 2022-08-09 Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów

Country Status (1)

Country Link
PL (1) PL441982A1 (pl)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180179179A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2019191624A1 (en) * 2018-03-29 2019-10-03 Arbutus Biopharma, Inc. Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same
EP3750887A1 (en) * 2018-02-05 2020-12-16 Abbisko Therapeutics Co., Ltd. Biaryl derivative, preparation method thereof and pharmaceutical application thereof
EP4001274A1 (en) * 2019-07-18 2022-05-25 Abbisko Therapeutics Co., Ltd. Biphenyl derivatives for blocking pd-1/pd-l1 interaction, preparation method therefor and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180179179A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3750887A1 (en) * 2018-02-05 2020-12-16 Abbisko Therapeutics Co., Ltd. Biaryl derivative, preparation method thereof and pharmaceutical application thereof
WO2019191624A1 (en) * 2018-03-29 2019-10-03 Arbutus Biopharma, Inc. Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same
EP4001274A1 (en) * 2019-07-18 2022-05-25 Abbisko Therapeutics Co., Ltd. Biphenyl derivatives for blocking pd-1/pd-l1 interaction, preparation method therefor and use thereof

Similar Documents

Publication Publication Date Title
PH12021500014A1 (en) Fused ring compounds
CR20200347A (es) Inhibidores pd-1/pd-l1
MX2021014441A (es) Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
MX2021014443A (es) Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
MX2020001598A (es) Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5).
EA033395B1 (ru) Ингибиторы индоламин-2,3-диоксигеназы и способы их применения
CA3010752A1 (en) Inhibitors of the pd-1/pd-l1 protein/protein interaction
MA50949B1 (fr) Anticorps anti-ctla-4 et leurs procédés d'utilisation
CA2962914C (en) Compounds and compositions for modulating egfr mutant kinase activities
MX2020007799A (es) Inhibidores de cinasa no derrepresible de control de aminoacido general 2 (gcn2) y sus usos.
MX2023008031A (es) Inhibidores de la cinasa 2 de control general no desrepresible (gcn2) y usos de los mismos.
EA201891191A1 (ru) 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения
MX2021004245A (es) Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
EA201791563A1 (ru) Замещенные нуклеозидные производные, полезные в качестве агентов против рака
EA201991884A2 (ru) Ингибиторы g12c kras
MX2015017486A (es) Inhibidores de indolamina 2,3-dioxigenasa (dio).
SA519410093B1 (ar) مركبات بيريميدو بيريميدينون مفيدة كمثبطات دبليو إى إى-1 كيناز
BR112021016056A2 (pt) Anticorpos de claudina 6 e usos dos mesmos
MX2021001471A (es) Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4).
MX2020009555A (es) Inhibidores selectivos de proteina arginina-metiltransferasa 5 (prmt5).
CR20210614A (es) Nuevos inhibidores de egfr
WO2018166993A3 (en) PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
PL441982A1 (pl) Niesymetrycznie podstawione pochodne 1,1'-bifenylu do stosowania w immunoterapii nowotworów
AU2020357395A8 (en) Bicyclic compound and use thereof
MX2023005716A (es) Derivados de cromeno como inhibidores de la interaccion receptor de antigeno de celula t (tcr) - region no catalitica de la proteina citosolica de la proteina tirosina cinasa (nck).