PL437711A1 - Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide - Google Patents

Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide

Info

Publication number
PL437711A1
PL437711A1 PL437711A PL43771121A PL437711A1 PL 437711 A1 PL437711 A1 PL 437711A1 PL 437711 A PL437711 A PL 437711A PL 43771121 A PL43771121 A PL 43771121A PL 437711 A1 PL437711 A1 PL 437711A1
Authority
PL
Poland
Prior art keywords
butylphthalide
isomer
hydroxy
preparing
water
Prior art date
Application number
PL437711A
Other languages
Polish (pl)
Other versions
PL242601B1 (en
Inventor
Joanna Gach
Teresa Olejniczak
Piotr Krężel
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL437711A priority Critical patent/PL242601B1/en
Publication of PL437711A1 publication Critical patent/PL437711A1/en
Publication of PL242601B1 publication Critical patent/PL242601B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania (-)-izomeru 3-hydroksy-3-butyloftalidu o wzorze 2. Postępując zgodnie z wynalazkiem, w wyniku działania enzymów pochodzących z komórek szczepu Chaetomium indicum AM 158, następuje addycja cząsteczki wody do wiązania podwójnego w łańcuchu bocznym 3-n-butylidenoftalidu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (octan etylu).The invention relates to a method for the production of the (-)-isomer of 3-hydroxy-3-butylphthalide of the formula 2. Following the invention, as a result of the action of enzymes derived from cells of the strain Chaetomium indicum AM 158, the addition of a water molecule to the double bond in the 3- n-butylidenephthalide. The product thus obtained is isolated from the aqueous culture of the micro-organism in a known manner by extraction with a water-immiscible organic solvent (ethyl acetate).

PL437711A 2021-04-27 2021-04-27 Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide PL242601B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL437711A PL242601B1 (en) 2021-04-27 2021-04-27 Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL437711A PL242601B1 (en) 2021-04-27 2021-04-27 Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide

Publications (2)

Publication Number Publication Date
PL437711A1 true PL437711A1 (en) 2022-10-31
PL242601B1 PL242601B1 (en) 2023-03-20

Family

ID=83852885

Family Applications (1)

Application Number Title Priority Date Filing Date
PL437711A PL242601B1 (en) 2021-04-27 2021-04-27 Method for preparing (-)-isomer of 3-hydroxy-3-butylphthalide

Country Status (1)

Country Link
PL (1) PL242601B1 (en)

Also Published As

Publication number Publication date
PL242601B1 (en) 2023-03-20

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