PL433975A1 - Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan - Google Patents

Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan

Info

Publication number
PL433975A1
PL433975A1 PL433975A PL43397520A PL433975A1 PL 433975 A1 PL433975 A1 PL 433975A1 PL 433975 A PL433975 A PL 433975A PL 43397520 A PL43397520 A PL 43397520A PL 433975 A1 PL433975 A1 PL 433975A1
Authority
PL
Poland
Prior art keywords
chitosan
bioactive
agent based
obtaining
cross
Prior art date
Application number
PL433975A
Other languages
Polish (pl)
Other versions
PL242855B1 (en
Inventor
Marek PIĄTKOWSKI
Julia RADWAN-PRAGŁOWSKA
Łukasz JANUS
Aleksandra SIERAKOWSKA
Original Assignee
Politechnika Krakowska im. Tadeusza Kościuszki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Krakowska im. Tadeusza Kościuszki filed Critical Politechnika Krakowska im. Tadeusza Kościuszki
Priority to PL433975A priority Critical patent/PL242855B1/en
Priority to PCT/IB2021/054169 priority patent/WO2021229538A1/en
Publication of PL433975A1 publication Critical patent/PL433975A1/en
Publication of PL242855B1 publication Critical patent/PL242855B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania bioaktywnego środka hemostatycznego, który polega na tym, że chitozan poddaje się reakcji sieciowania fizycznego, stosując poli(kwas asparaginowy), a następnie inkorporuje się lizozym w strukturę usieciowanego chitozanu, przy czym reakcję sieciowania prowadzi się w temperaturze pokojowej, pod normalnym ciśnieniem. Stosunek masowy chitozanu : czynnika sieciującego wynosi od 1:0,1 do 1:6, a ilość lizozymu wynosi 12,5 - 25 mg na 1 g chitozanu. Wynalazek dotyczy także bioaktywnego środka hemostatycznego na bazie chitozanu uzyskanego tym sposobem.The subject of the application is a method of obtaining a bioactive hemostatic agent, which consists in subjecting chitosan to a physical cross-linking reaction using poly (aspartic acid), and then incorporating lysozyme into the structure of cross-linked chitosan, the cross-linking reaction being carried out at room temperature under normal pressure. The mass ratio of chitosan: cross-linker is from 1: 0.1 to 1: 6, and the amount of lysozyme is 12.5-25 mg per 1 g of chitosan. The invention also relates to a chitosan-based bioactive hemostatic agent obtained by this method.

PL433975A 2020-05-14 2020-05-14 Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan PL242855B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL433975A PL242855B1 (en) 2020-05-14 2020-05-14 Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan
PCT/IB2021/054169 WO2021229538A1 (en) 2020-05-14 2021-05-14 Method for obtaining chitosan-based bioactive hemostatic agent and chitosan-based bioactive hemostatic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL433975A PL242855B1 (en) 2020-05-14 2020-05-14 Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan

Publications (2)

Publication Number Publication Date
PL433975A1 true PL433975A1 (en) 2021-11-15
PL242855B1 PL242855B1 (en) 2023-05-02

Family

ID=77104097

Family Applications (1)

Application Number Title Priority Date Filing Date
PL433975A PL242855B1 (en) 2020-05-14 2020-05-14 Method of obtaining a bioactive hemostatic agent based on chitosan and a bioactive haemostatic agent based on chitosan

Country Status (2)

Country Link
PL (1) PL242855B1 (en)
WO (1) WO2021229538A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100412113C (en) * 2006-08-18 2008-08-20 天津理工大学 Method for preparing interpolymer bionic membrane material of poly-asparagine and chitosan
CN104162182B (en) * 2014-08-06 2016-04-13 暨南大学 A kind of have active compound hemostatic powder of antibacterial heal-promoting conjunction and preparation method thereof

Also Published As

Publication number Publication date
PL242855B1 (en) 2023-05-02
WO2021229538A1 (en) 2021-11-18

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