PL432649A1 - Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs - Google Patents

Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs

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Publication number
PL432649A1
PL432649A1 PL432649A PL43264920A PL432649A1 PL 432649 A1 PL432649 A1 PL 432649A1 PL 432649 A PL432649 A PL 432649A PL 43264920 A PL43264920 A PL 43264920A PL 432649 A1 PL432649 A1 PL 432649A1
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PL
Poland
Prior art keywords
titanium
drug
phosphates
polymer
drugs
Prior art date
Application number
PL432649A
Other languages
Polish (pl)
Other versions
PL236822B1 (en
Inventor
Alicja Kazek-Kęsik
Monika Śmiga-Matuszowicz
Wojciech Simka
Original Assignee
Politechnika Śląska
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Publication date
Application filed by Politechnika Śląska filed Critical Politechnika Śląska
Priority to PL432649A priority Critical patent/PL236822B1/en
Publication of PL432649A1 publication Critical patent/PL432649A1/en
Publication of PL236822B1 publication Critical patent/PL236822B1/en

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  • Materials For Medical Uses (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób otrzymywania warstw polimerowych na powierzchni tytanu lub stopów tytanu na bazie polimeru z fosforanami i lekami charakteryzujący się tym, że tytan lub stop tytanu utlenia się anodowo w kąpieli wodnej zawierającej podfosforyn wapnia o stężeniu 0,001 mol/dm3 - 10 mol/dm3 stosując napięcie zaciskowe w zakresie od 0,1 V do 800 V, anodową gęstością prądu w zakresie 5 - 500 A/dm2 a następnie tak utleniony tytan lub stop tytanu umieszcza się w roztworze na bazie pochodnej kwasu adypinowego, rozpuszczalnika korzystnie dichlorometanu, leku korzystnie antybiotyku lub leku przeciwzapalnego korzystnie niesteroidowego lub leku immunosupresyjnego lub leku przeciwgrzybicznego lub leku przeciwwirusowego stosowanego w leczeniu tkanek twardych okołowszczepowych, w ilości od 0,0001 g/L do 1000 g/L oraz nierozpuszczalnych związków fosforanów cynku korzystnie (Zn3(PO4)2) i/lub fosforanów korzystnie miedzi korzystnie (Cu3(PO4)2) i/lub fosforanów srebra korzystnie (Ag3PO4), a następnie suszy.The subject of the application is a method of obtaining polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs, characterized in that the titanium or titanium alloy is anodically oxidized in a water bath containing calcium hypophosphite at a concentration of 0.001 mol / dm3 - 10 mol / dm3 using pinch voltage ranging from 0.1 V to 800 V, anodic current density ranging from 5 - 500 A / dm2, and then the so oxidized titanium or titanium alloy is placed in a solution based on an adipic acid derivative, a solvent preferably dichloromethane, a drug preferably an antibiotic or an anti-inflammatory drug, preferably a non-steroidal drug, or an immunosuppressive drug, or an antifungal drug, or an antiviral drug used in the treatment of peri-implant hard tissues, in an amount from 0.0001 g / L to 1000 g / L, and zinc phosphate insoluble compounds preferably (Zn3 (PO4) 2) and / or phosphates, preferably copper (Cu3 (PO4) 2), and / or silver phosphates, preferably (Ag3PO4 ) and then dried.

PL432649A 2020-01-21 2020-01-21 Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs PL236822B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL432649A PL236822B1 (en) 2020-01-21 2020-01-21 Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL432649A PL236822B1 (en) 2020-01-21 2020-01-21 Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs

Publications (2)

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PL432649A1 true PL432649A1 (en) 2020-09-07
PL236822B1 PL236822B1 (en) 2021-02-22

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Family Applications (1)

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PL432649A PL236822B1 (en) 2020-01-21 2020-01-21 Method for producing polymer layers on the surface of titanium or titanium alloys based on a polymer with phosphates and drugs

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PL (1) PL236822B1 (en)

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Publication number Publication date
PL236822B1 (en) 2021-02-22

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