PL431708A1 - Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation - Google Patents

Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation

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Publication number
PL431708A1
PL431708A1 PL431708A PL43170819A PL431708A1 PL 431708 A1 PL431708 A1 PL 431708A1 PL 431708 A PL431708 A PL 431708A PL 43170819 A PL43170819 A PL 43170819A PL 431708 A1 PL431708 A1 PL 431708A1
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PL
Poland
Prior art keywords
arginine
copper
hydrate
bis
crystalline form
Prior art date
Application number
PL431708A
Other languages
Polish (pl)
Other versions
PL238889B1 (en
Inventor
Agnieszka Wojciechowska
Jan Janczak
Original Assignee
Politechnika Wrocławska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL431708A priority Critical patent/PL238889B1/en
Publication of PL431708A1 publication Critical patent/PL431708A1/en
Publication of PL238889B1 publication Critical patent/PL238889B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Wynalazek dotyczy krystalicznej formy kompleksu bis(L-arginina)di(tiocyjaniano)miedź(II) hydrat 1/2, znajdującej zastosowanie jako składnik leku o wolnym uwalnianiu i kontrolowanym stężeniu teofiliny. Wynalazek zapewnia również sposób wytwarzania krystalicznej formy kompleksu bis(L-arginina)di(tiocyjaniano)miedź(II) hydrat 1/2, który charakteryzuje się tym, że jedną część molową uwodnionej soli mrówczanu miedzi (II), rozpuszcza się w wodzie i poddaje się reakcji z jedną częścią molową wodnego roztworu L-argininy, po czym powstałą mieszaninę poddaje się reakcji z dwiema lub trzema częściami molowymi wodnego roztworu KSCN, po 1 dniu otrzymuje się zielony proszek, który odfiltrowuje się a klarowną mieszaninę pozostawia się do dalszego powolnego odparowywania a po minimum 20 dniach otrzymuje się krystaliczną formę bis(L-arginina)di(tiocyjaniano)miedź(II) hydrat 1/2.The invention relates to a crystalline form of the complex bis (L-arginine) di (thiocyanate) copper (II) hydrate 1/2, which is used as a drug component with a slow release and controlled concentration of theophylline. The invention also provides a method for the preparation of a crystalline form of the bis (L-arginine) di (thiocyanate) copper (II) hydrate 1/2 complex, which is characterized in that one mole part of hydrated copper (II) formate salt is dissolved in water and subjected to is reacted with one part by mole of aqueous L-arginine, then the resulting mixture is reacted with two or three parts by mole of aqueous solution of KSCN, after 1 day a green powder is obtained, which is filtered off and the clear mixture is allowed to evaporate further slowly and after a minimum of 20 days, the crystalline form of bis (L-arginine) di (thiocyanato) copper (II) hydrate 1/2 is obtained.

PL431708A 2019-11-04 2019-11-04 Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation PL238889B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL431708A PL238889B1 (en) 2019-11-04 2019-11-04 Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431708A PL238889B1 (en) 2019-11-04 2019-11-04 Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation

Publications (2)

Publication Number Publication Date
PL431708A1 true PL431708A1 (en) 2021-05-17
PL238889B1 PL238889B1 (en) 2021-10-18

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ID=75882833

Family Applications (1)

Application Number Title Priority Date Filing Date
PL431708A PL238889B1 (en) 2019-11-04 2019-11-04 Crystalline form of bis(L-arginine)di(thiocyanate)copper(II) hydrate 1/2 complex and method of its preparation

Country Status (1)

Country Link
PL (1) PL238889B1 (en)

Also Published As

Publication number Publication date
PL238889B1 (en) 2021-10-18

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