PL425551A1 - (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it - Google Patents

(4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it

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Publication number
PL425551A1
PL425551A1 PL42555118A PL42555118A PL425551A1 PL 425551 A1 PL425551 A1 PL 425551A1 PL 42555118 A PL42555118 A PL 42555118A PL 42555118 A PL42555118 A PL 42555118A PL 425551 A1 PL425551 A1 PL 425551A1
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PL
Poland
Prior art keywords
dimethylphenyl
methyltetrahydropyran
bromo
obtaining
hex
Prior art date
Application number
PL42555118A
Other languages
Polish (pl)
Other versions
PL235029B1 (en
Inventor
Witold Gładkowski
Angelika Sysak
Aleksandra Pawlak
Aleksandra Włoch
Bożena Obmińska-Mrukowicz
Halina Kleszczyńska
Marcelina Mazur
Original Assignee
Wrocław University Of Environmental And Life Sciences
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Application filed by Wrocław University Of Environmental And Life Sciences filed Critical Wrocław University Of Environmental And Life Sciences
Priority to PL425551A priority Critical patent/PL235029B1/en
Publication of PL425551A1 publication Critical patent/PL425551A1/en
Publication of PL235029B1 publication Critical patent/PL235029B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Zgłoszenie dotyczy optycznie czynnego (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimetylofenylo)-6-c-metylotetrahydropiran-2-onu o wzorze 1, oraz sposobu jego otrzymywania. Sposób ten polega na tym, że kwas (S,E)-3-(2',5'-dimetylofenylo)-heks-4-enowy poddaje się reakcji bromolaktonizacji otrzymując mieszaninę produktów, z której następnie metodą chromatografii kolumnowej wydziela się w postaci czystej (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimetylofenylo)-6-c-metylotetrahydropiran-2-on.The application relates to an optically active (4R, 5R, 6S) -5-t-bromo-4-r- (2 ', 5'-dimethylphenyl) -6-c-methyltetrahydropyran-2-one of the formula 1 and its preparation. In this method, (S, E) -3- (2 ', 5'-dimethylphenyl) -hex-4-enoic acid is subjected to a bromolactonization reaction to obtain a mixture of products, which is then separated by column chromatography in pure form. (4R, 5R, 6S) -5-t-bromo-4-r- (2 ', 5'-dimethylphenyl) -6-c-methyltetrahydropyran-2-one.

PL425551A 2018-05-15 2018-05-15 (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it PL235029B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL425551A PL235029B1 (en) 2018-05-15 2018-05-15 (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL425551A PL235029B1 (en) 2018-05-15 2018-05-15 (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it

Publications (2)

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PL425551A1 true PL425551A1 (en) 2019-11-18
PL235029B1 PL235029B1 (en) 2020-05-18

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PL425551A PL235029B1 (en) 2018-05-15 2018-05-15 (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it

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PL235029B1 (en) 2020-05-18

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