Wrocław University Of Environmental And Life Sciences
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Priority to PL425551ApriorityCriticalpatent/PL235029B1/en
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Publication of PL235029B1publicationCriticalpatent/PL235029B1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Zgłoszenie dotyczy optycznie czynnego (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimetylofenylo)-6-c-metylotetrahydropiran-2-onu o wzorze 1, oraz sposobu jego otrzymywania. Sposób ten polega na tym, że kwas (S,E)-3-(2',5'-dimetylofenylo)-heks-4-enowy poddaje się reakcji bromolaktonizacji otrzymując mieszaninę produktów, z której następnie metodą chromatografii kolumnowej wydziela się w postaci czystej (4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimetylofenylo)-6-c-metylotetrahydropiran-2-on.The application relates to an optically active (4R, 5R, 6S) -5-t-bromo-4-r- (2 ', 5'-dimethylphenyl) -6-c-methyltetrahydropyran-2-one of the formula 1 and its preparation. In this method, (S, E) -3- (2 ', 5'-dimethylphenyl) -hex-4-enoic acid is subjected to a bromolactonization reaction to obtain a mixture of products, which is then separated by column chromatography in pure form. (4R, 5R, 6S) -5-t-bromo-4-r- (2 ', 5'-dimethylphenyl) -6-c-methyltetrahydropyran-2-one.
PL425551A2018-05-152018-05-15(4R,5R,6S)-5-t-bromo-4-r-(2',5'-dimethylphenyl)-6-c-methyltetrahydropyran-2-one and method for obtaining it
PL235029B1
(en)
ENANTIOMER [R] PURE 5 - {[2-FLUORO-4- (2-OXO-2H-PIRIDIN-1-IL) -PENYL] -AMIDA} 1 - [(4-CHLORINE-PHENYL) -AMIDE] OF THE ACID [R] -5-METHYL-4, 5-DIHIDRO-PIRAZOL-1, 5-DICARBOXILICO, A METHOD FOR THE PREPARATION OF THE COMPOSITE MENTIONED, A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, CRYSTALLINE FORMS OF THE SAME AND
SOLID FORMS OF 2-[3-[4-AMINO-3-(2-FLUORINE-4-PHENOXY-PHENYL)PYRAZOLE[3,4-D]PYRIMIDIN-1-YL]PIPERIDINE-1-CARBONYL]-4-METHYL -4-[4-(OXETAN-3-IL)PIPERAZIN-1-IL]PENT-2-ENENITRILE
(+)-rel-(1R.6R, 1'R)-1-(1'-Chloroethyl)-9--oxabicyclo[4.3.0]nonan-8-one and method of obtaining (+)-rel-(1R .6R,1'R)-1-(1'-chloroethyl)-9-oxabicyclo[4.3.0]nonan-8-one
(+)-rel-(1R,6R,1'R)-1-(1'-Bromoethyl)-9-oxabicyclo[4.3.0]nonan-8-one and method of obtaining (+)-rel-(1R,6R,1'R)-1-(1'-bromoethyl)-9-oxabicyclo[4.3.0]nonan-8-one