PL424971A1 - Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells - Google Patents
Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cellsInfo
- Publication number
- PL424971A1 PL424971A1 PL424971A PL42497118A PL424971A1 PL 424971 A1 PL424971 A1 PL 424971A1 PL 424971 A PL424971 A PL 424971A PL 42497118 A PL42497118 A PL 42497118A PL 424971 A1 PL424971 A1 PL 424971A1
- Authority
- PL
- Poland
- Prior art keywords
- human body
- scaffolds
- chitosan
- injection
- intended
- Prior art date
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- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania żeli chitozanowych, formujących się w temperaturze ciała ludzkiego, przeznaczonych na skafoldy iniekcyjne do hodowli komórek nerwowych, który polega na wprowadzeniu do schłodzonego do temperatury 4°C roztworu wodnego octanu, chlorku, mleczanu chitozanu, sporządzonego z chitozanu o stopniu deacetylacji powyżej 70% i o masie cząsteczkowej 500 - 700 kDa, kroplami schłodzonego także do temperatury 4°C roztworu wodnego soli disodowej 5'-monofosforanu urydyny, zmieszaniu składników i odpowietrzeniu w temperaturze 4°C w czasie 24 godzin powstałego zolu przechodzącego w postać żelu w temperaturze ciała ludzkiego. Do roztworu soli chitozanu, przed wprowadzeniem roztworu soli 5'-monofosforanu urydyny, wprowadza się także środki wspomagające regenerację nerwów, jak kobalamina, kwas liponowy, tlenek grafenu.The subject of the application is a method for the production of chitosan gels, formed at the temperature of the human body, intended for injection scaffolds for the cultivation of nerve cells, which consists in introducing a cooled to 4 ° C aqueous solution of chitosan acetate, chloride, lactate, made of chitosan with a deacetylation degree above 70% and with a molecular weight of 500 - 700 kDa, dropwise, also cooled to a temperature of 4 ° C, an aqueous solution of uridine 5'-monophosphate disodium salt, mixing the components and deaerating at 4 ° C during 24 hours of the resulting sol transforming into a gel at a temperature of the human body. Nerve regeneration aids such as cobalamin, lipoic acid, graphene oxide are also introduced into the chitosan salt solution, prior to the introduction of the uridine 5'-monophosphate salt solution.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL424971A PL235369B1 (en) | 2018-03-20 | 2018-03-20 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL424971A PL235369B1 (en) | 2018-03-20 | 2018-03-20 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Publications (2)
Publication Number | Publication Date |
---|---|
PL424971A1 true PL424971A1 (en) | 2019-09-23 |
PL235369B1 PL235369B1 (en) | 2020-06-29 |
Family
ID=67979742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL424971A PL235369B1 (en) | 2018-03-20 | 2018-03-20 | Method for producing chitosan gels forming in the human body temperature, intended for injection scaffolds for breeding of nerve cells |
Country Status (1)
Country | Link |
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PL (1) | PL235369B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL219576B1 (en) * | 2010-11-22 | 2015-05-29 | Politechnika Łódzka | Process for the preparation of a temperature-sensitive chitosan hydrogel containing calcium and phosphorus |
CN104983672A (en) * | 2015-06-26 | 2015-10-21 | 青岛大学 | Preparation method for temperature-sensitive sol |
-
2018
- 2018-03-20 PL PL424971A patent/PL235369B1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL219576B1 (en) * | 2010-11-22 | 2015-05-29 | Politechnika Łódzka | Process for the preparation of a temperature-sensitive chitosan hydrogel containing calcium and phosphorus |
CN104983672A (en) * | 2015-06-26 | 2015-10-21 | 青岛大学 | Preparation method for temperature-sensitive sol |
Non-Patent Citations (1)
Title |
---|
ZOFIA MODRZEJEWSKA, BIOLOGICAL PROPERTIES OF THERMOSENSITIVE CHITOSAN GELS CONDITIONING IN WATER, 2015 * |
Also Published As
Publication number | Publication date |
---|---|
PL235369B1 (en) | 2020-06-29 |
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