PL423865A1 - Method for producing biodegradable external stents intended for putting over blood vessels and the biodegradable external stent intended for putting over blood vessels, obtained by this method - Google Patents
Method for producing biodegradable external stents intended for putting over blood vessels and the biodegradable external stent intended for putting over blood vessels, obtained by this methodInfo
- Publication number
- PL423865A1 PL423865A1 PL423865A PL42386517A PL423865A1 PL 423865 A1 PL423865 A1 PL 423865A1 PL 423865 A PL423865 A PL 423865A PL 42386517 A PL42386517 A PL 42386517A PL 423865 A1 PL423865 A1 PL 423865A1
- Authority
- PL
- Poland
- Prior art keywords
- fiber
- biodegradable
- stent
- blood vessels
- diameter
- Prior art date
Links
Abstract
Przedmiotem zgłoszenia jest biodegradowalny stent zewnętrzny, przeznaczony do nakładania na naczynia krwionośne, w postaci cylindrycznej rurki, który obejmuje żebrowanie zarówno zewnętrznej jak i wewnętrznej powierzchni ściany stentu, przy czym w przekroju podłużnym stentu żebrowanie ściany jest zbliżone profilem do sinusoidy, której dwa grzbiety są w odległości odpowiadającej skokowi nawoju sprężyny na walcu, przy czym średnica żebra (g) mieści się w zakresie od 6,5 do 13,5% średnicy wewnętrznej (d) stentu, skok nawoju żebrowania (s) mieści się w zakresie od 200 do 800% średnicy żebra (g), a kąt nawoju jest zasadniczo taki sam na całej długości nawoju, przy czym ściany stentu wykonane są z materiału włóknistego zawierającego włóknotwórczy, biodegradowalny poliester alifatyczny i biopolimer białkowy, przy czym włóknotwórczy, biodegradowalny poliester alifatyczny ma czas biodegradacji in vivo nie krótszy niż 6 miesięcy, przy czym korzystnie produkty jego rozkładu nie wywołują reakcji zapalnej. Przedmiotem zgłoszenia jest także sposób wytwarzania biodegradowalnych stentów zewnętrznych przeznaczonych do nakładania na naczynia krwionośne, który obejmuje etapy: a) przygotowania roztworu włóknotwórczego, biodegradowalnego poliestru alifatycznego oraz biopolimeru białkowego w rozpuszczalniku organicznym, przy czym włóknotwórczy, biodegradowalny poliester alifatyczny ma czas biodegradacji in vivo nie krótszy niż 6 miesięcy, przy czym korzystnie produkty jego rozkładu nie wywołują reakcji zapalnej, b) elektroprzędzenia roztworu włóknotwórczego z pkt. a), z wykorzystaniem niskoprądowego generatora wysokiego napięcia, pompy dozującej wymieniony roztwór włóknotwórczy, kolektora obrotowego, przy czym aktywną funkcję zbierania włókien pełni walec z żebrowaną w sposób spiralny powierzchnią, przy czym średnica żebra (g) mieści się w zakresie od 6,5 do 13,5% średnicy walca (d) i skok nawoju żebrowania (s) mieści się w zakresie od 200 do 800% średnicy żebra (g) i przy czym kąt nawoju jest zasadniczo taki sam na całej długości nawoju. Zgłoszenie dotyczy również biodegradowalnego stentu zewnętrznego wytwarzanego tym sposobem.The subject of the application is a biodegradable external stent, intended for application to blood vessels, in the form of a cylindrical tube, which includes ribbing of both the external and internal surface of the stent wall, where in the longitudinal section of the stent the ribbing of the wall is similar to a sinusoid, whose two ridges are in distance corresponding to the spring winding stroke on the cylinder, with the rib diameter (g) in the range from 6.5 to 13.5% of the inner diameter (d) of the stent, the pitch of the ribbing (s) in the range from 200 to 800% rib diameter (g) and the winding angle is essentially the same over the entire length of the winding, with the walls of the stent being made of a fibrous material containing a fiber-forming, biodegradable aliphatic polyester and a protein biopolymer, wherein the fiber-forming, biodegradable aliphatic polyester has no in vivo biodegradation time less than 6 months, with root Only its degradation products do not cause an inflammatory reaction. The subject of the application is also a method for producing biodegradable external stents for application to blood vessels, which includes the steps of: a) preparing a fiber-forming solution, a biodegradable aliphatic polyester and a protein biopolymer in an organic solvent, where the fiber-forming, biodegradable aliphatic polyester has in vivo biodegradable time than 6 months, but preferably its decomposition products do not cause an inflammatory reaction, b) electrospinning of the fiber-forming solution from point a), using a low-voltage high-voltage generator, a dosing pump for said fiber-forming solution, a rotary collector, the active function of fiber collection is a roller with a spirally ribbed surface, the diameter of the rib (g) being in the range from 6.5 to 13.5% of the cylinder diameter (d) and the pitch of the finning rib (s) are in the range from 200 to 800% of the rib diameter (g) and the winding angle is substantially the same over the entire length of the bundle. The application also relates to a biodegradable external stent produced by this method.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL423865A PL236613B1 (en) | 2017-12-13 | 2017-12-13 | Method for producing biodegradable external stents intended for putting over blood vessels and the biodegradable external stent intended for putting over blood vessels, obtained by this method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL423865A PL236613B1 (en) | 2017-12-13 | 2017-12-13 | Method for producing biodegradable external stents intended for putting over blood vessels and the biodegradable external stent intended for putting over blood vessels, obtained by this method |
Publications (2)
Publication Number | Publication Date |
---|---|
PL423865A1 true PL423865A1 (en) | 2019-06-17 |
PL236613B1 PL236613B1 (en) | 2021-02-08 |
Family
ID=66809799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL423865A PL236613B1 (en) | 2017-12-13 | 2017-12-13 | Method for producing biodegradable external stents intended for putting over blood vessels and the biodegradable external stent intended for putting over blood vessels, obtained by this method |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL236613B1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137605B1 (en) * | 1983-08-03 | 1988-06-08 | Shiley Incorporated | Vascular graft prosthesis |
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2017
- 2017-12-13 PL PL423865A patent/PL236613B1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0137605B1 (en) * | 1983-08-03 | 1988-06-08 | Shiley Incorporated | Vascular graft prosthesis |
Non-Patent Citations (4)
Title |
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ATSUHIKO SATO, A NOVEL BIODEGRADABLE EXTERNAL MESH STENT IMPROVED LONGTERM PATENCY OF VEIN GRAFTS BY INHIBITING INTIMAL-MEDIAL HYPERPLASIA IN AN EXPERIMENTAL CANINE MODEL, 2016 * |
MITSURU SATO, MEDIAL REGENERATION USING A BIODEGRADABLE FELT AS A SCAFFOLD PRESERVES INTEGRITY AND COMPLIANCE OF A CANINE DISSECTED AORTA, November 2012 (2012-11-01) * |
VEERAM REDDY SR, A NOVEL BIODEGRADABLE STENT APPLICABLE FOR USE IN CONGENITAL HEART DISEASE: BENCH TESTING AND FEASIBILITY RESULTS IN A RABBIT MODEL, February 2014 (2014-02-01) * |
VIJAYAN V.ET, LONG-TERM REDUCTION OF MEDIAL AND INTIMAL THICKENING IN PORCINE SAPHENOUS VEIN GRAFTS WITH A POLYGLACTIN BIODEGRADABLE EXTERNAL SHEATH, November 2004 (2004-11-01) * |
Also Published As
Publication number | Publication date |
---|---|
PL236613B1 (en) | 2021-02-08 |
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