PL422526A1 - N-substituted compounds of tacrine, method for producing and application of those compounds - Google Patents
N-substituted compounds of tacrine, method for producing and application of those compoundsInfo
- Publication number
- PL422526A1 PL422526A1 PL422526A PL42252617A PL422526A1 PL 422526 A1 PL422526 A1 PL 422526A1 PL 422526 A PL422526 A PL 422526A PL 42252617 A PL42252617 A PL 42252617A PL 422526 A1 PL422526 A1 PL 422526A1
- Authority
- PL
- Poland
- Prior art keywords
- application
- carbon atom
- compounds
- tacrine
- acridine
- Prior art date
Links
Abstract
Przedmiotem zgłoszenia jest N-podstawiony związek takryny o wzorze 1, w którym R1, R2, R3, R4 są niezależne wybrane z grupy obejmującej atom wodoru, atom fluorowca, grupę nitrową, grupę aminową, grupę metylową, grupę metoksylową, grupę hydroksylową, grupę trifluorometylową, A oznacza dwuwartościowy fragment alkilenowy, ewentualnie rozgałęziony, mający od dwóch do dwunastu atomów węgla, przy czym łańcuch główny fragmentu alkilenowego A zawiera co najmniej dwa atomy węgla, B oznacza akrydynę, przy czym linia poprowadzona pomiędzy atomem węgla ugrupowania karboksamidowego a podstawnikiem B oznacza wiązanie pojedyncze łączące niewęzłowy atom węgla akrydyny z atomem węgla grupy karbonylowej; albo jego hydrat, solwat lub farmakologicznie dopuszczalna sól. Zgłoszenie dotyczy także wytwarzania przedmiotowego związku i kwasu akrydynokarboksylowego, a także stosowania związków o wzorze 1, w terapii do leczenia choroby nowotworowej ze współistniejącą chorobą Alzheimera.The subject of the application is an N-substituted tacrine compound of formula 1 in which R1, R2, R3, R4 are independently selected from the group consisting of hydrogen, halogen, nitro, amino, methyl, methoxy, hydroxyl, trifluoromethyl , A is a divalent alkylene fragment, optionally branched, having from two to twelve carbon atoms, where the main chain of the alkylene fragment A contains at least two carbon atoms, B is acridine, the line drawn between the carbon atom of the carboxamide moiety and the substituent B is a bond single connecting a non-node acridine carbon atom to a carbonyl group carbon atom; or a hydrate, solvate or pharmacologically acceptable salt thereof. The application also relates to the preparation of the subject compound and acridinecarboxylic acid, as well as the use of compounds of formula 1 in therapy for the treatment of cancer with co-morbid Alzheimer's disease.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422526A PL235351B1 (en) | 2017-08-09 | 2017-08-09 | N-substituted compounds of tacrine, method for producing and application of those compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422526A PL235351B1 (en) | 2017-08-09 | 2017-08-09 | N-substituted compounds of tacrine, method for producing and application of those compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PL422526A1 true PL422526A1 (en) | 2019-02-11 |
PL235351B1 PL235351B1 (en) | 2020-06-29 |
Family
ID=65270289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL422526A PL235351B1 (en) | 2017-08-09 | 2017-08-09 | N-substituted compounds of tacrine, method for producing and application of those compounds |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL235351B1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194403B1 (en) * | 1999-09-09 | 2001-02-27 | Unitech Pharmaceuticals, Inc. | Tacrine derivatives for treating Alzheimer's disease |
WO2004032929A2 (en) * | 2002-10-09 | 2004-04-22 | Neuropharma, S.A. | Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer’s disease |
WO2014180984A1 (en) * | 2013-05-09 | 2014-11-13 | Ikerchem, S.L. | Histone deacetylase inhibitors based on derivatives of tricyclic polyhydroacridine and analogs possessing fused saturated five- and seven-membered rings |
-
2017
- 2017-08-09 PL PL422526A patent/PL235351B1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194403B1 (en) * | 1999-09-09 | 2001-02-27 | Unitech Pharmaceuticals, Inc. | Tacrine derivatives for treating Alzheimer's disease |
WO2004032929A2 (en) * | 2002-10-09 | 2004-04-22 | Neuropharma, S.A. | Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer’s disease |
WO2014180984A1 (en) * | 2013-05-09 | 2014-11-13 | Ikerchem, S.L. | Histone deacetylase inhibitors based on derivatives of tricyclic polyhydroacridine and analogs possessing fused saturated five- and seven-membered rings |
Also Published As
Publication number | Publication date |
---|---|
PL235351B1 (en) | 2020-06-29 |
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