PL420169A1 - N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them - Google Patents

N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them

Info

Publication number
PL420169A1
PL420169A1 PL420169A PL42016915A PL420169A1 PL 420169 A1 PL420169 A1 PL 420169A1 PL 420169 A PL420169 A PL 420169A PL 42016915 A PL42016915 A PL 42016915A PL 420169 A1 PL420169 A1 PL 420169A1
Authority
PL
Poland
Prior art keywords
amino
indolo
guanyl
dimethyl
derivatives
Prior art date
Application number
PL420169A
Other languages
Polish (pl)
Inventor
Katarzyna Sidoryk
Monika Kaczmarska
Iwona Bujak
Krzysztof Bańkowski
Łukasz Kaczmarek
Original Assignee
Instytut Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny
Publication of PL420169A1 publication Critical patent/PL420169A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia są N-guanylowe pochodne 9-amino-5,11-dimetylo-5H-indolo[2,3-b]chinoliny o wzorze (I), w którym n oznacza liczbę całkowitą 0 lub 1, i R oznacza łańcuch boczny acylującego ?-aminokwasu, który stanowi glicyna lub L-prolina oraz ich farmaceutycznie dopuszczalne sole. N-Guanylowe pochodne 9-amino-5,11-dimetylo-5H-indolo[2,3-b]chinolin-9-ylo-aminy, charakteryzują się wysoką aktywnością cytotoksyczną oraz selektywnością działania. Ze względu na właściwości fizykochemiczne i farmakologiczne mogą stanowić składnik aktywny środków farmaceutycznych do leczenia lub profilaktyki różnych rodzajów nowotworów. W zgłoszeniu ujawniono także sposób otrzymywania N-guanylowych pochodnych 9-amino-5,11-dimetylo-5H-indolo[2,3-b]chinoliny.The subject of the application are N-guanyl 9-amino-5,11-dimethyl-5H-indolo [2,3-b] quinoline derivatives of formula (I) in which n is an integer 0 or 1, and R is an acylating side chain β-amino acid which is glycine or L-proline and their pharmaceutically acceptable salts. N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo [2,3-b] quinolin-9-ylamine are characterized by high cytotoxic activity and selectivity. Due to their physicochemical and pharmacological properties, they can be the active ingredient of pharmaceutical agents for the treatment or prevention of various types of cancer. The application also discloses a method for preparing N-guanyl 9-amino-5,11-dimethyl-5H-indolo [2,3-b] quinoline derivatives.

PL420169A 2014-03-28 2015-03-27 N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them PL420169A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL407711A PL407711A1 (en) 2014-03-28 2014-03-28 Derivatives of N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them
PCT/PL2015/000053 WO2015147666A1 (en) 2014-03-28 2015-03-27 N-guanyl derivatives of 9-amino-5.1 1 -dimethyl-5h-indolo[2,3-b]quinoline having cytotoxic activity

Publications (1)

Publication Number Publication Date
PL420169A1 true PL420169A1 (en) 2017-07-31

Family

ID=53055081

Family Applications (2)

Application Number Title Priority Date Filing Date
PL407711A PL407711A1 (en) 2014-03-28 2014-03-28 Derivatives of N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them
PL420169A PL420169A1 (en) 2014-03-28 2015-03-27 N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL407711A PL407711A1 (en) 2014-03-28 2014-03-28 Derivatives of N-Guanyl derivatives of 9-amino-5,11-dimethyl-5H-indolo[2,3-b]quinoline, method for obtaining them and pharmaceuticals containing them

Country Status (2)

Country Link
PL (2) PL407711A1 (en)
WO (1) WO2015147666A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201835075A (en) * 2017-02-14 2018-10-01 德商麥克專利有限公司 Materials for organic electroluminescent devices
US20230331721A1 (en) * 2020-10-06 2023-10-19 Dana-Farber Cancer Institute, Inc. Potent and selective covalent inhibitors of serine-arginine protein kinase (srpk) 1 and srpk2 and uses thereof
CN115350189B (en) * 2022-09-22 2023-05-30 兰州大学 Application of sinomenine derivative in preparation of medicines for treating colorectal cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL117621B1 (en) 1978-05-16 1981-08-31 Akad Sztuk Pieknych Filtration head for colour photography
PL206681B1 (en) 2002-05-10 2010-09-30 Fundacja Na Rzecz Wspierania R Carbohydrate derivatives of quinoline [2,3-b] indole and method of their receiving
PL202545B1 (en) 2004-04-02 2009-07-31 Inst Farmaceutyczny Carbohydrate derivatives of 5,11-dimethyl-5H-indole[2,3-b]quinoline and method for their obtaining as well as pharmaceuticals containing these derivatives
PL219085B1 (en) 2010-03-26 2015-03-31 Inst Farmaceutyczny Derivatives of 5,11-dimethyl-5H-indole [2,3-b] quinoline

Also Published As

Publication number Publication date
WO2015147666A1 (en) 2015-10-01
PL407711A1 (en) 2015-10-12

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