PL418944A1 - 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it
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1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it
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Publication of PL231815B1publicationCriticalpatent/PL231815B1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Zgłoszenie dotyczy 1'-palmitoilo-2'-[2-(2"-butylideno-1",3",3"-trimetylo)cykloheksylo]acetylo-sn-glicero-3'-fosfocholiny, o wzorze 1, przedstawionym na rysunku oraz sposobu jej otrzymywania na drodze estryfikacji 1-palmitoilo-sn-glicero-3-fosfocholiny kwasem 2-(2-butylideno-1,3,3-trimetylocykloheksylo)-octowym z udziałem czynnika sprzęgającego jakim jest N,N'-dicykloheksylokarbodiimid oraz w obecności 4-dimetyloaminopirydyny w środowisku bezwodnego chlorku metylenu lub chloroformu. Fosfolipid ten może znaleźć zastosowanie w przemyśle farmaceutycznym jako prolek w terapii chorób nowotworowych.The application relates to 1'-palmitoyl-2 '- [2- (2 "-butylidene-1", 3 ", 3" -trimethyl) cyclohexyl] acetyl-sn-glycerol-3'-phosphocholine, of formula 1, shown in figure and the method of its preparation by esterification of 1-palmitoyl-sn-glycerol-3-phosphocholine with 2- (2-butylidene-1,3,3-trimethylcyclohexyl) acetic acid with the participation of a coupling agent which is N, N'-dicyclohexylcarbodiimide and presence of 4-dimethylaminopyridine in anhydrous methylene chloride or chloroform. This phospholipid may find application in the pharmaceutical industry as a prodrug in the therapy of cancer.
PL418944A2016-09-302016-09-301'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it
PL231815B1
(en)
1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it
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1'2'-Di[3,7,11-trimethyl-3-vinyldodeca-6,10-dienyl]-sn-glycero-3'-phosphocholine and method for obtaining 1'2'-di[3,7,11-trimethyl-3-vinyldodeca-6,10-dienyl]-sn-glycero-3'-phosphocholine