PL418944A1 - 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it - Google Patents

1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it

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Publication number
PL418944A1
PL418944A1 PL418944A PL41894416A PL418944A1 PL 418944 A1 PL418944 A1 PL 418944A1 PL 418944 A PL418944 A PL 418944A PL 41894416 A PL41894416 A PL 41894416A PL 418944 A1 PL418944 A1 PL 418944A1
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PL
Poland
Prior art keywords
phosphocholine
butylidene
palmitoyl
trimethyl
acetyl
Prior art date
Application number
PL418944A
Other languages
Polish (pl)
Other versions
PL231815B1 (en
Inventor
Anna Gliszczyńska
Natalia Niezgoda
Witold Gładkowski
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL418944A priority Critical patent/PL231815B1/en
Publication of PL418944A1 publication Critical patent/PL418944A1/en
Publication of PL231815B1 publication Critical patent/PL231815B1/en

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Abstract

Zgłoszenie dotyczy 1'-palmitoilo-2'-[2-(2"-butylideno-1",3",3"-trimetylo)cykloheksylo]acetylo-sn-glicero-3'-fosfocholiny, o wzorze 1, przedstawionym na rysunku oraz sposobu jej otrzymywania na drodze estryfikacji 1-palmitoilo-sn-glicero-3-fosfocholiny kwasem 2-(2-butylideno-1,3,3-trimetylocykloheksylo)-octowym z udziałem czynnika sprzęgającego jakim jest N,N'-dicykloheksylokarbodiimid oraz w obecności 4-dimetyloaminopirydyny w środowisku bezwodnego chlorku metylenu lub chloroformu. Fosfolipid ten może znaleźć zastosowanie w przemyśle farmaceutycznym jako prolek w terapii chorób nowotworowych.The application relates to 1'-palmitoyl-2 '- [2- (2 "-butylidene-1", 3 ", 3" -trimethyl) cyclohexyl] acetyl-sn-glycerol-3'-phosphocholine, of formula 1, shown in figure and the method of its preparation by esterification of 1-palmitoyl-sn-glycerol-3-phosphocholine with 2- (2-butylidene-1,3,3-trimethylcyclohexyl) acetic acid with the participation of a coupling agent which is N, N'-dicyclohexylcarbodiimide and presence of 4-dimethylaminopyridine in anhydrous methylene chloride or chloroform. This phospholipid may find application in the pharmaceutical industry as a prodrug in the therapy of cancer.

PL418944A 2016-09-30 2016-09-30 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it PL231815B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL418944A PL231815B1 (en) 2016-09-30 2016-09-30 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL418944A PL231815B1 (en) 2016-09-30 2016-09-30 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it

Publications (2)

Publication Number Publication Date
PL418944A1 true PL418944A1 (en) 2017-11-20
PL231815B1 PL231815B1 (en) 2019-04-30

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ID=60324391

Family Applications (1)

Application Number Title Priority Date Filing Date
PL418944A PL231815B1 (en) 2016-09-30 2016-09-30 1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it

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PL (1) PL231815B1 (en)

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Publication number Publication date
PL231815B1 (en) 2019-04-30

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