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Publication of PL229269B1publicationCriticalpatent/PL229269B1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Zgłoszenie dotyczy 1',2'-di[(3,7,11,15-tetrametylo-3-winyloheksadecylo]-sn-glicero-3'-fosfocholina o wzorze 1 oraz sposobu jej otrzymywania na drodze estryfikacji kwasu 3,7,11,15-tetrametylo-3-winyloheksadekanowego kompleksem sn-glicero-3-fosfocholiny i chlorku kadmu z udziałem czynnika sprzęgającego jakim jest N,N'-dicykloheksylokarbodiimid oraz w obecności 4-dimetyloaminopirydyny w środowisku bezwodnego chlorku metylenu. Rozwiązanie może znaleźć zastosowanie w terapii chorób nowotworowych.The application relates to 1 ', 2'-di [(3,7,11,15-tetramethyl-3-vinylhexadecyl] -sn-glycero-3'-phosphocholine of formula 1 and the method for its preparation by acid esterification 3,7,11 , 15-tetramethyl-3-vinylhexadecane complex of sn-glycerol-3-phosphocholine and cadmium chloride with the coupling agent N, N'-dicyclohexylcarbodiimide and in the presence of 4-dimethylaminopyridine in anhydrous methylene chloride. The solution may find application in the therapy of diseases cancer.
PL418942A2016-09-302016-09-301'2'-Di[(3,7,11,15-tetramethyl-3-vinylhexadecyl]-sn-glycero-3'-phosphocholine and method for obtaining it
PL229269B1
(en)
1'2'-Di[3,7,11-trimethyl-3-vinyldodeca-6,10-dienyl]-sn-glycero-3'-phosphocholine and method for obtaining 1'2'-di[3,7,11-trimethyl-3-vinyldodeca-6,10-dienyl]-sn-glycero-3'-phosphocholine
1'2'-Di-[3,7-dimethyl-3-vinylocta-6-enyl]-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di-[3,7-dimethyl-3-vinylocta-6-enyl]-sn-glycero-3'-phosphocholine
1',2'-Di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine and method for obtaining 1',2'-di{2-[(2''E)-2''-butylidene-1'',3'',3''-trimethyl]cyclohexyl}acetyl-sn-glycero-3'-phosphocholine
1'-Palmitoyl-2'-[2-(2''-butylidene-1'',3'',3''-trimethyl)cyclohexyl]acetyl-sn-glycero-3'-phosphocholine and method for obtaining it