PL414762A1 - New cyclobutane-1,1-dicarboxylate platinum(II) complexes with 5,7-disubstituted-1,2,4-triazole[1,5-a]pyrimidines and method for producing them - Google Patents

New cyclobutane-1,1-dicarboxylate platinum(II) complexes with 5,7-disubstituted-1,2,4-triazole[1,5-a]pyrimidines and method for producing them

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Publication number
PL414762A1
PL414762A1 PL414762A PL41476215A PL414762A1 PL 414762 A1 PL414762 A1 PL 414762A1 PL 414762 A PL414762 A PL 414762A PL 41476215 A PL41476215 A PL 41476215A PL 414762 A1 PL414762 A1 PL 414762A1
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PL
Poland
Prior art keywords
complexes
cbdc
platinum
ibmtp
pti2
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PL414762A
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Polish (pl)
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PL230465B1 (en
Inventor
Iwona Łakomska
Kamil Hoffman
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Uniwersytet Mikołaja Kopernika W Toruniu
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Application filed by Uniwersytet Mikołaja Kopernika W Toruniu filed Critical Uniwersytet Mikołaja Kopernika W Toruniu
Priority to PL414762A priority Critical patent/PL230465B1/en
Publication of PL414762A1 publication Critical patent/PL414762A1/en
Publication of PL230465B1 publication Critical patent/PL230465B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Przedmiotem zgłoszenia są nowe dikarboksylowe kompleksy platyny(II) z 5,7-dimetylo- 1,2,4-triazolo[1,5-a]pirymidyną (dmtp) albo 7-izobutylo-5-metylo-1,2,4-triazolo[1,5-a]pirymidyną (ibmtp) albo 5,7-ditertbutylo-1,2,4-triazolo[1,5-a]pirymidyną (dbtp) o wzorach odpowiednio: [Pt(1,1-CBDC)(dmtp)2], [Pt(1,1-CBDC)(ibmtp)2] oraz [Pt(1,1-CBDC)(dbtp)2] a 1,1-CBDC oznacza dianion cyklobutano-1,1-dikarboksylowy. Zgłoszenie obejmuje także sposób wytwarzania nowych dikarboksylowych kompleksów platyny(II) charakteryzujący się tym, że do mieszaniny acetonu i wody w stosunku objętościowym od 9:1 do 1:5, dodaje się cis-[PtI2(dmtp)2] albo cis-[PtI2(ibmtp)2] albo cis-[PtI2(dbtp)2] oraz cyklobutano-1,1-dikarboksylan srebra w stosunku molowym odpowiednio 1:1 i bez dostępu do światła miesza przez okres od 20 do 100 godzin, po czym mieszaninę poreakcyjną odwirowuje się, oddzieloną ciecz przesącza a klarowny roztwór zatęża w strumieniu powietrza o temperaturze od 15°C do 25°C, po czym suszy poprzez liofilizacje.The subject of the application are new dicarboxylic complexes of platinum (II) with 5,7-dimethyl-1,2,4-triazolo [1,5-a] pyrimidine (dmtp) or 7-isobutyl-5-methyl-1,2,4- triazolo [1,5-a] pyrimidine (ibmtp) or 5,7-ditertbutyl-1,2,4-triazolo [1,5-a] pyrimidine (dbtp) with the formulas respectively: [Pt (1,1-CBDC) (dmtp) 2], [Pt (1,1-CBDC) (ibmtp) 2] and [Pt (1,1-CBDC) (dbtp) 2] and 1,1-CBDC means cyclobutane-1,1-dicarboxylic dianion . The application also includes a process for the production of new dicarboxylic complexes of platinum (II) characterized in that cis- [PtI2 (dmtp) 2] or cis- [PtI2 is added to a mixture of acetone and water in a volume ratio of 9: 1 to 1: 5 (ibmtp) 2] or cis- [PtI2 (dbtp) 2] and silver cyclobutane-1,1-dicarboxylate in a 1: 1 molar ratio, respectively, and without access to light, mixing for 20 to 100 hours, after which the reaction mixture is centrifuged , the separated liquid is filtered and the clear solution is concentrated in a stream of air at a temperature of 15 ° C to 25 ° C, and then dried by lyophilization.

PL414762A 2015-11-12 2015-11-12 New cyclobutane-1,1-dicarboxylate platinum(II) complexes with 5,7-disubstituted-1,2,4-triazole[1,5-a]pyrimidines and method for producing them PL230465B1 (en)

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PL414762A PL230465B1 (en) 2015-11-12 2015-11-12 New cyclobutane-1,1-dicarboxylate platinum(II) complexes with 5,7-disubstituted-1,2,4-triazole[1,5-a]pyrimidines and method for producing them

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Application Number Priority Date Filing Date Title
PL414762A PL230465B1 (en) 2015-11-12 2015-11-12 New cyclobutane-1,1-dicarboxylate platinum(II) complexes with 5,7-disubstituted-1,2,4-triazole[1,5-a]pyrimidines and method for producing them

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PL414762A1 true PL414762A1 (en) 2017-05-22
PL230465B1 PL230465B1 (en) 2018-10-31

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018063016A1 (en) * 2016-09-29 2018-04-05 Uniwersytet Mikołaja Kopernika W Toruniu New platinum(ii) dicarboxylate complexes with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine and dimethyl sulfoxide, and their preparation method
US11814734B2 (en) 2019-05-13 2023-11-14 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018063016A1 (en) * 2016-09-29 2018-04-05 Uniwersytet Mikołaja Kopernika W Toruniu New platinum(ii) dicarboxylate complexes with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine and dimethyl sulfoxide, and their preparation method
US11814734B2 (en) 2019-05-13 2023-11-14 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor

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PL230465B1 (en) 2018-10-31

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