PL410454A1 - Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis - Google Patents

Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis

Info

Publication number
PL410454A1
PL410454A1 PL410454A PL41045414A PL410454A1 PL 410454 A1 PL410454 A1 PL 410454A1 PL 410454 A PL410454 A PL 410454A PL 41045414 A PL41045414 A PL 41045414A PL 410454 A1 PL410454 A1 PL 410454A1
Authority
PL
Poland
Prior art keywords
psoriasis
patient
response
genistein
treatment
Prior art date
Application number
PL410454A
Other languages
Polish (pl)
Inventor
Grzegorz Węgrzyn
Magdalena Gabig-Cimińska
Joanna Jakóbkiewicz-Banecka
Marta Moskot
Elwira Smolińska
Original Assignee
Uniwersytet Gdański
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Gdański filed Critical Uniwersytet Gdański
Priority to PL410454A priority Critical patent/PL410454A1/en
Priority to PCT/PL2015/000198 priority patent/WO2016093718A1/en
Priority to EP15828396.0A priority patent/EP3230470A1/en
Publication of PL410454A1 publication Critical patent/PL410454A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Przedmiotem wynalazku jest sposób identyfikowania molekularnej odpowiedzi pacjenta chorego na łuszczycę na leczenie genisteiną, gdzie określa się w próbce biologicznej pobranej od pacjenta poziom ekspresji 30 genów przedstawionych poniżej: EZH2, CDC42EP5, F12, GJB2, KRT6B, MALL, PI3, SFT2D2, SRM, SYNCRIP, THBD, ACACB, CAT, FADS1, FASN, FOXC1, FOXO1, JUN, MEGF9, MYH10, PCYOX1 RHOB, RHOBTB3, SSPN, TIMP3, TUFT1, UST, ZNF12, ZNF483, ZNF652. Ujawniono także molekularny test do wykrywania odpowiedzi pacjenta chorego na łuszczycę na leczenie genisteiną oraz zastosowanie ekspresji 30 genów do wykrywania in vitro łuszczycy u pacjenta.The subject of the invention is a method of identifying the molecular response of a patient suffering from psoriasis to genistein treatment, where the level of expression of 30 genes specified in the biological sample taken from the patient is determined: EZH2, CDC42EP5, F12, GJB2, KRT6B, MALL, PI3, SFT2D2, SRM, SYNCRIP , THBD, ACACB, CAT, FADS1, FASN, FOXC1, FOXO1, JUN, MEGF9, MYH10, PCYOX1 RHOB, RHOBTB3, SSPN, TIMP3, TUFT1, UST, ZNF12, ZNF483, ZNF652. Also disclosed is a molecular test for detecting a patient's psoriasis response to genistein treatment and the use of gene expression for in vitro detection of psoriasis in a patient.

PL410454A 2014-12-08 2014-12-08 Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis PL410454A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL410454A PL410454A1 (en) 2014-12-08 2014-12-08 Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis
PCT/PL2015/000198 WO2016093718A1 (en) 2014-12-08 2015-12-08 Methods for identifying response of patients suffering from psoriasis to genistein treatment and molecular assays therefor
EP15828396.0A EP3230470A1 (en) 2014-12-08 2015-12-08 Methods for identifying response of patients suffering from psoriasis to genistein treatment and molecular assays therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL410454A PL410454A1 (en) 2014-12-08 2014-12-08 Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis

Publications (1)

Publication Number Publication Date
PL410454A1 true PL410454A1 (en) 2016-06-20

Family

ID=55221478

Family Applications (1)

Application Number Title Priority Date Filing Date
PL410454A PL410454A1 (en) 2014-12-08 2014-12-08 Method for identification of response of a patient with psoriasis disease to treatment with genistein, molecular test and application of gene expressions for the in vitro detection of psoriasis

Country Status (3)

Country Link
EP (1) EP3230470A1 (en)
PL (1) PL410454A1 (en)
WO (1) WO2016093718A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101933694B1 (en) 2017-06-30 2018-12-28 동국대학교 산학협력단 Diagnostic kit comprising biomarkers for genistein exposure diagnosis
CN110004220A (en) * 2019-01-11 2019-07-12 北京蛋白质组研究中心 A kind of psoriasis blood serum designated object and its application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1358348A2 (en) * 2000-05-09 2003-11-05 Genetics Institute, LLC Compositions, kits, and methods for identification, assessment, prevention, and therapy of psoriasis
BRPI0620914A2 (en) * 2005-12-28 2011-11-29 Centocor Inc markers and methods for assessing and treating psoriasis and related disorders
EP2212442A1 (en) * 2007-10-26 2010-08-04 Galderma Research & Development Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof

Also Published As

Publication number Publication date
EP3230470A1 (en) 2017-10-18
WO2016093718A1 (en) 2016-06-16

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