PL402263A1 - Morpholine and morpholine-nitroimidazole derivatives of phthalocyanines, their preparation and use - Google Patents

Morpholine and morpholine-nitroimidazole derivatives of phthalocyanines, their preparation and use

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Publication number
PL402263A1
PL402263A1 PL402263A PL40226312A PL402263A1 PL 402263 A1 PL402263 A1 PL 402263A1 PL 402263 A PL402263 A PL 402263A PL 40226312 A PL40226312 A PL 40226312A PL 402263 A1 PL402263 A1 PL 402263A1
Authority
PL
Poland
Prior art keywords
morpholine
preparation
phthalocyanines
formula
nitroimidazole derivatives
Prior art date
Application number
PL402263A
Other languages
Polish (pl)
Other versions
PL222376B1 (en
Inventor
Marcin Wierzchowski
Tomasz Gośliński
Wojciech Szczotko
Paulina Skupin-Mrugalska
Stanisław Sobiak
Marek Murias
Małgorzata Kucińska
Sebastian Lijewski
Mateusz Ściepura
Maciej Korpusiński
Original Assignee
Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu filed Critical Uniwersytet Medyczny Im. Karola Marcinkowskiego W Poznaniu
Priority to PL402263A priority Critical patent/PL222376B1/en
Publication of PL402263A1 publication Critical patent/PL402263A1/en
Publication of PL222376B1 publication Critical patent/PL222376B1/en

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Abstract

Przedmiotem wynalazku są nowe morfolinowe oraz morfolinowo-nitroimidazolowe pochodne ftalocyjanin o ogólnym wzorze 1, sposób ich otrzymywania oraz zastosowanie do wytwarzania leków stosowanych w terapii fotodynamicznej, w którym - M oznacza 2H, Mg(II), Zn(II), Mn(II), Mn(III)Cl, Fe(II), Fe(III)Cl, Co(II), Cu(II) a podstawnikami R1, R2, R3, R4, R5, R6, R7 i R8 jest H lub grupy o wzorze 2 lub wzorze 3. Przedmiotem wynalazku są również sole o ogólnym wzorze 1 gdzie podstawniki R1 R2 R3, R4, R5, R6, R7 i R8 oznaczają H lub grupę o wzorze 4 i sposób ich otrzymywania. Wynalazek obejmuje również zastosowanie, związków do wytwarzania leków stosowanych w terapiach przeciwnowotworowych w szczególności PDT.The subject of the invention are new morpholino and morpholino-nitroimidazole derivatives of phthalocyanines of the general formula 1, a method for their preparation and use for the production of drugs used in photodynamic therapy, in which - M is 2H, Mg(II), Zn(II), Mn(II) , Mn(III)Cl, Fe(II), Fe(III)Cl, Co(II), Cu(II) and the substituents R1, R2, R3, R4, R5, R6, R7 and R8 are H or groups of the formula 2 or Formula 3. The invention also relates to salts of the general formula 1 where R1 R2 R3, R4, R5, R6, R7 and R8 are H or a group of formula 4 and a method for their preparation. The invention also includes the use of compounds for the production of drugs used in anticancer therapies, in particular PDT.

PL402263A 2012-12-27 2012-12-27 Morpholino, and morpholino nitro-imidazole phthalocyanine derivatives, process for their preparation and the use PL222376B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL402263A PL222376B1 (en) 2012-12-27 2012-12-27 Morpholino, and morpholino nitro-imidazole phthalocyanine derivatives, process for their preparation and the use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL402263A PL222376B1 (en) 2012-12-27 2012-12-27 Morpholino, and morpholino nitro-imidazole phthalocyanine derivatives, process for their preparation and the use

Publications (2)

Publication Number Publication Date
PL402263A1 true PL402263A1 (en) 2014-07-07
PL222376B1 PL222376B1 (en) 2016-07-29

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Family Applications (1)

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PL402263A PL222376B1 (en) 2012-12-27 2012-12-27 Morpholino, and morpholino nitro-imidazole phthalocyanine derivatives, process for their preparation and the use

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PL222376B1 (en) 2016-07-29

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