PL3902779T3 - Sposób wytwarzania egzo-n-(3-azabicyklo[3.2.1]oktan- 8-ylo)-karbaminianu tert-butylu - Google Patents

Sposób wytwarzania egzo-n-(3-azabicyklo[3.2.1]oktan- 8-ylo)-karbaminianu tert-butylu

Info

Publication number
PL3902779T3
PL3902779T3 PL19835672.7T PL19835672T PL3902779T3 PL 3902779 T3 PL3902779 T3 PL 3902779T3 PL 19835672 T PL19835672 T PL 19835672T PL 3902779 T3 PL3902779 T3 PL 3902779T3
Authority
PL
Poland
Prior art keywords
octan
azabicyclo
carbamate
tert
butyl
Prior art date
Application number
PL19835672.7T
Other languages
English (en)
Inventor
Weichun Chen
Guocai ZHANG
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL3902779T3 publication Critical patent/PL3902779T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL19835672.7T 2018-12-27 2019-12-24 Sposób wytwarzania egzo-n-(3-azabicyklo[3.2.1]oktan- 8-ylo)-karbaminianu tert-butylu PL3902779T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018124296 2018-12-27
CN2019093185 2019-06-27
PCT/EP2019/087000 WO2020136188A1 (en) 2018-12-27 2019-12-24 Process for the preparation exo-tert-butyl n-(3-azabicyclo[3.2.1]octan-8-yl)carbamate

Publications (1)

Publication Number Publication Date
PL3902779T3 true PL3902779T3 (pl) 2023-05-15

Family

ID=69159752

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19835672.7T PL3902779T3 (pl) 2018-12-27 2019-12-24 Sposób wytwarzania egzo-n-(3-azabicyklo[3.2.1]oktan- 8-ylo)-karbaminianu tert-butylu

Country Status (12)

Country Link
US (1) US20220073469A1 (pl)
EP (1) EP3902779B1 (pl)
JP (1) JP2022515610A (pl)
KR (1) KR20210110309A (pl)
CN (1) CN113165992A (pl)
AU (1) AU2019412747A1 (pl)
CA (1) CA3112418A1 (pl)
ES (1) ES2940185T3 (pl)
IL (1) IL283994B2 (pl)
MX (1) MX2021006955A (pl)
PL (1) PL3902779T3 (pl)
WO (1) WO2020136188A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023006715A (es) 2020-12-11 2023-06-23 Hoffmann La Roche Proceso para la preparacion de (9s)-n-[3-(6-metilpirimidin-4-il)-3 -azabiciclo[3.2.1]octan-8-il]-9-(2,3,4-trifluorofenil)-6,7,8,9-te trahidro-5h-[1,2,4]triazolo[1,5-a]azepin-2-amina y su forma solida.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227684B1 (en) * 2003-08-29 2011-11-28 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
CN103570621B (zh) * 2013-05-17 2015-04-29 万邦德制药集团股份有限公司 一种（-）-石杉碱甲的制备
US20190322676A1 (en) 2016-12-20 2019-10-24 Biomarin Pharmaceutical Inc. Ceramide galactosyltransferase inhibitors for the treatment of disease

Also Published As

Publication number Publication date
KR20210110309A (ko) 2021-09-07
IL283994B2 (en) 2024-05-01
EP3902779A1 (en) 2021-11-03
JP2022515610A (ja) 2022-02-21
TW202039441A (zh) 2020-11-01
WO2020136188A1 (en) 2020-07-02
MX2021006955A (es) 2021-07-15
CA3112418A1 (en) 2020-07-02
IL283994A (en) 2021-07-29
AU2019412747A1 (en) 2021-04-08
EP3902779B1 (en) 2023-01-18
IL283994B1 (en) 2024-01-01
US20220073469A1 (en) 2022-03-10
CN113165992A (zh) 2021-07-23
ES2940185T3 (es) 2023-05-04

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