PL3755318T3 - Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń - Google Patents

Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń

Info

Publication number
PL3755318T3
PL3755318T3 PL19756525.2T PL19756525T PL3755318T3 PL 3755318 T3 PL3755318 T3 PL 3755318T3 PL 19756525 T PL19756525 T PL 19756525T PL 3755318 T3 PL3755318 T3 PL 3755318T3
Authority
PL
Poland
Prior art keywords
disorders
treatment
modified
cannabis sativa
substance addiction
Prior art date
Application number
PL19756525.2T
Other languages
English (en)
Inventor
Jonnie R. Williams
Original Assignee
Mymd Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mymd Pharmaceuticals, Inc. filed Critical Mymd Pharmaceuticals, Inc.
Publication of PL3755318T3 publication Critical patent/PL3755318T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/28—Cannabaceae, e.g. cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03007—Tetrahydrocannabinolic acid synthase (1.21.3.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03008—Cannabidiolic acid synthase (1.21.3.8)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Addiction (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nutrition Science (AREA)
  • Environmental Sciences (AREA)
PL19756525.2T 2018-02-20 2019-02-11 Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń PL3755318T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862632448P 2018-02-20 2018-02-20
PCT/US2019/017433 WO2019164689A1 (en) 2018-02-20 2019-02-11 Genetically modified cannabis sativa plants and modified cannabinoid compounds for treatment of substance addiction and other disorders

Publications (1)

Publication Number Publication Date
PL3755318T3 true PL3755318T3 (pl) 2022-12-19

Family

ID=67687826

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19756525.2T PL3755318T3 (pl) 2018-02-20 2019-02-11 Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń
PL21171866.3T PL3884936T3 (pl) 2018-02-20 2019-02-11 Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL21171866.3T PL3884936T3 (pl) 2018-02-20 2019-02-11 Genetycznie zmodyfikowane rośliny cannabis sativa i zmodyfikowane związki kannabinoidowe do leczenia uzależnień od substancji i innych zaburzeń

Country Status (13)

Country Link
US (4) US11085047B2 (pl)
EP (2) EP3884936B1 (pl)
JP (2) JP7293561B2 (pl)
KR (2) KR102374793B1 (pl)
CN (2) CN113264914A (pl)
AU (2) AU2019225717B2 (pl)
CA (2) CA3091776C (pl)
ES (2) ES2929366T3 (pl)
HU (2) HUE060229T2 (pl)
IL (2) IL276518B (pl)
PL (2) PL3755318T3 (pl)
PT (2) PT3884936T (pl)
WO (1) WO2019164689A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4938547B2 (ja) 2007-05-10 2012-05-23 日本トムソン株式会社 内面シールを備えた直動案内ユニット
US20240000808A1 (en) * 2020-11-16 2024-01-04 Orcosa Inc. Improved use of cannabinoids in the treatment of alzheimer's disease
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
MX2023006076A (es) * 2020-11-24 2023-08-09 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Derivados de cannabinoides y su uso en el tratamiento de la inflamación y/o el dolor y/o la obesidad.
WO2022180532A1 (en) * 2021-02-23 2022-09-01 Puregene Ag Quantitative trait loci (qtls) associated with a high-varin trait in cannabis
CN113099973B (zh) * 2021-05-17 2022-05-27 潍坊市华以农业科技有限公司 一种药用大麻矮化高产的种植方法
AU2022397237A1 (en) * 2021-11-27 2024-05-16 Miralogx Llc Synthetic cannabinoid compounds, pharmaceutical compositions, and treatment methods
WO2023150347A2 (en) * 2022-02-07 2023-08-10 Miralogx Llc Synthetic cannabinoid compounds, pharmaceutical compositions, and treatment methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942244A (en) 1997-07-31 1999-08-24 Farmo-Nat Ltd. Local oral herbal slow release tablets
GB2438682A (en) * 2006-06-01 2007-12-05 Gw Pharma Ltd New use for cannabinoids
DE102007046086A1 (de) * 2007-09-26 2009-04-09 Heinz Prof. Dr. Letzel Pflanzenextrakt aus THC-armen Cannabis zur Behandlung von Erkrankungen
GB2456183A (en) * 2008-01-04 2009-07-08 Gw Pharma Ltd Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament
US8884100B2 (en) 2009-08-12 2014-11-11 National Research Council Of Canada Aromatic prenyltransferase from Cannabis
GB2478595B (en) * 2010-03-12 2018-04-04 Gw Pharma Ltd Phytocannabinoids in the treatment of glioma
GB201111261D0 (en) * 2011-07-01 2011-08-17 Gw Pharma Ltd Cannabinoids for use in the treatment of neuro-degenerative diseases or disorders
GB201117956D0 (en) * 2011-10-18 2011-11-30 Otsuka Pharma Co Ltd Phytocannabinoids for use in the treatment of breast cancer
US20160108016A1 (en) * 2012-09-06 2016-04-21 Northeastern University Novel Cannabinergic Compounds and Uses Thereof
CA2957953C (en) 2014-06-27 2021-10-19 National Research Council Of Canada (Nrc) Cannabichromenic acid synthase from cannabis sativa
WO2016004121A1 (en) 2014-07-01 2016-01-07 MJAR Holdings, LLC High cannabidiol cannabis strains
EP3556376A1 (en) * 2015-01-22 2019-10-23 Phytoplant Research S.L. Methods of purifying cannabinoids, compositions and kits thereof
AU2016215094B2 (en) 2015-02-05 2019-09-26 Colorado Can Llc Purified CBD and CBDA, and methods, compositions and products employing CBD or CBDA
BR112017025388A2 (pt) * 2015-05-28 2018-08-07 Tweed Inc. plantas cannabis tendo expressão modificada de thca sintase
US10059683B2 (en) * 2015-07-10 2018-08-28 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
US11466283B2 (en) * 2016-08-18 2022-10-11 Canopy Growth Corporation Plants and methods for increasing and decreasing synthesis of cannabinoids

Also Published As

Publication number Publication date
CN113264914A (zh) 2021-08-17
AU2021202296B2 (en) 2021-11-11
EP3755318A1 (en) 2020-12-30
IL282342B (en) 2022-02-01
EP3755318A4 (en) 2021-04-14
CA3120993C (en) 2022-06-21
JP7322353B2 (ja) 2023-08-08
IL282342A (en) 2021-05-31
IL276518A (en) 2020-09-30
US10787675B2 (en) 2020-09-29
AU2019225717A1 (en) 2020-10-08
US11629355B2 (en) 2023-04-18
CN112040942A (zh) 2020-12-04
EP3884936A1 (en) 2021-09-29
KR20210055794A (ko) 2021-05-17
US20230212597A1 (en) 2023-07-06
AU2019225717B2 (en) 2021-10-21
CA3120993A1 (en) 2019-08-29
PL3884936T3 (pl) 2022-12-05
JP7293561B2 (ja) 2023-06-20
EP3884936B1 (en) 2022-10-12
PT3755318T (pt) 2022-09-05
AU2021202296A1 (en) 2021-05-13
ES2929366T3 (es) 2022-11-28
CA3091776A1 (en) 2019-08-29
JP2021507937A (ja) 2021-02-25
US12129473B2 (en) 2024-10-29
US20210380998A1 (en) 2021-12-09
WO2019164689A1 (en) 2019-08-29
ES2926328T3 (es) 2022-10-25
IL276518B (en) 2021-04-29
HUE060229T2 (hu) 2023-02-28
KR102374793B1 (ko) 2022-03-17
EP3755318B1 (en) 2022-08-24
KR20200128050A (ko) 2020-11-11
PT3884936T (pt) 2022-10-25
CA3091776C (en) 2021-12-28
JP2021113213A (ja) 2021-08-05
US11085047B2 (en) 2021-08-10
US20200061138A1 (en) 2020-02-27
KR102332631B1 (ko) 2021-12-01
HUE059916T2 (hu) 2023-01-28
US20200155629A1 (en) 2020-05-21

Similar Documents

Publication Publication Date Title
IL276518B (en) Genetically Modified Cannabis Sativa Plants and Modified Cannabinoid Compounds for the Treatment of Substance Addiction and Other Disorders
ZA201900986B (en) Plants and methods for increasing and decreasing synthesis of cannabinoids
IL272627A (en) Terpene-enriched cannabinoid compositions and method of treatment
IL304526A (en) Production of compounds and preparations to inhibit the activity of shp2
IL298689B1 (en) Preparations and methods for suppressing masp-3 for the treatment of various diseases and conditions
EP3902553A4 (en) ENRICHED CANNABINOID COMPOSITION IN HERBAL PREPARATION AND METHOD OF TREATMENT
DK3717471T3 (da) Nye forbindelser og lægemiddelsammensætninger heraf til behandling af sygdomme
IL269302A (en) Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders
IL291735A (en) Heteroarylbiphenylamines for the treatment of pd-l1 diseases
EP3615657A4 (en) APPARATUS, METHODS AND COMPOSITION FOR THE SYNTHESIS OF CANNABINOID COMPOUNDS
EP3193862C0 (en) TOPICAL COMPOSITION OF CANNABINOIDS FOR THE TREATMENT OF ARTHRITIS PAIN
HUE068098T2 (hu) Eljárás eliglusztát és köztitermékei elõállítására
EP3707275A4 (en) DOSAGE AND STRATEGY RECOMMENDATIONS FOR THE TREATMENT OF MEDICAL CONDITIONS USING CANNABIS
PL3651586T3 (pl) Sposób izolacji białka z materiału roślinnego
ZA201906213B (en) Compounds and methods for the treatment of parasitic diseases
EP3681477A4 (en) PROCEDURES AND IMPROVED COMPOSITION FOR TREATMENT OF TREITERPEN RESPONSIBLE CONDITIONS, DISEASES, OR DISORDERS
EP3713558C0 (en) AMINOADAMANTYL NITRATE COMPOUNDS AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS
IL292086A (en) Methods of making feminized cannabis sativa seed and compositions thereof
IL275653A (en) Purified cannabis extracts and methods for their preparation
IL284112A (en) A method for extracting proteins from cannabis plant material
EP3251699A4 (en) Composition and method for treatment of neuropsychiatric disorders
IL275941B (en) Physical means and methods for influencing cannabis plants
IL282003A (en) Methods of making platelets comprising modified receptors and uses thereof
IL259674B (en) Benzofuran derivatives for the treatment of diseases related to the central nervous system and other diseases
ZA202001140B (en) Derivatives of luciferin and methods for their synthesis