PL3700514T3 - Połączenie inhibitorów il-8 i inhibitorów il-6/gp-130 do zastosowania w leczeniu przerzutów do płuc związanych z kostniakomięsakiem - Google Patents

Połączenie inhibitorów il-8 i inhibitorów il-6/gp-130 do zastosowania w leczeniu przerzutów do płuc związanych z kostniakomięsakiem

Info

Publication number
PL3700514T3
PL3700514T3 PL18795414.4T PL18795414T PL3700514T3 PL 3700514 T3 PL3700514 T3 PL 3700514T3 PL 18795414 T PL18795414 T PL 18795414T PL 3700514 T3 PL3700514 T3 PL 3700514T3
Authority
PL
Poland
Prior art keywords
inhibitors
metastasas
osteosarcoma
lung
treatment
Prior art date
Application number
PL18795414.4T
Other languages
English (en)
Inventor
Ryan David ROBERTS
Laura Brandolini
Original Assignee
Dompé Farmaceutici S.P.A.
The Research Institute At Nationwide Children's Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompé Farmaceutici S.P.A., The Research Institute At Nationwide Children's Hospital filed Critical Dompé Farmaceutici S.P.A.
Publication of PL3700514T3 publication Critical patent/PL3700514T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL18795414.4T 2017-10-24 2018-10-23 Połączenie inhibitorów il-8 i inhibitorów il-6/gp-130 do zastosowania w leczeniu przerzutów do płuc związanych z kostniakomięsakiem PL3700514T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17198072.5A EP3476390A1 (en) 2017-10-24 2017-10-24 Il-8 inhibitors for use in the treatment of sarcomas
PCT/EP2018/078971 WO2019081470A1 (en) 2017-10-24 2018-10-23 IL-8 INHIBITORS FOR USE IN THE TREATMENT OF CERTAIN SARCOMES

Publications (1)

Publication Number Publication Date
PL3700514T3 true PL3700514T3 (pl) 2025-07-07

Family

ID=60162145

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18795414.4T PL3700514T3 (pl) 2017-10-24 2018-10-23 Połączenie inhibitorów il-8 i inhibitorów il-6/gp-130 do zastosowania w leczeniu przerzutów do płuc związanych z kostniakomięsakiem

Country Status (23)

Country Link
US (2) US11660291B2 (pl)
EP (3) EP3476390A1 (pl)
JP (2) JP2021500413A (pl)
KR (2) KR20200091405A (pl)
AU (1) AU2018356497B2 (pl)
BR (1) BR112020007940A2 (pl)
CA (1) CA3079781A1 (pl)
DK (1) DK3700514T3 (pl)
ES (1) ES3029183T3 (pl)
FI (1) FI3700514T3 (pl)
HR (1) HRP20250641T1 (pl)
HU (1) HUE071855T2 (pl)
IL (1) IL274031B2 (pl)
LT (1) LT3700514T (pl)
MA (1) MA50449A (pl)
MD (1) MD3700514T2 (pl)
PL (1) PL3700514T3 (pl)
PT (1) PT3700514T (pl)
RS (1) RS66852B1 (pl)
SG (1) SG11202003622TA (pl)
SI (1) SI3700514T1 (pl)
SM (1) SMT202500202T1 (pl)
WO (1) WO2019081470A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017220539A1 (de) 2017-11-17 2019-05-23 Zf Friedrichshafen Ag Verfahren zum Betreiben eines Systems aus einem landwirtschaftlichen Arbeitsfahrzeug und zumindest einem an diesem angeordneten Arbeitsgerät

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1303249B1 (it) * 1998-10-23 2000-11-06 Dompe Spa Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono.
US20030096781A1 (en) * 2001-08-31 2003-05-22 University Of Southern California IL-8 is an autocrine growth factor and a surrogate marker for Kaposi's sarcoma
PT1776336E (pt) 2004-03-23 2009-12-18 Dompe Spa Derivados de ácido 2-fenilpropiónico e composições farmacêuticas que os contêm
EP2166006A1 (en) 2008-09-18 2010-03-24 Dompe' S.P.A. 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
JP5716180B2 (ja) 2008-11-11 2015-05-13 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 抗cxcr1組成物および方法
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
MA41044A (fr) * 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
US20170165363A1 (en) * 2015-12-11 2017-06-15 The Johns Hopkins University Cancer cell migration inhibitors and their use in therapeutic treatments
US12268671B2 (en) 2016-01-15 2025-04-08 Dompé Farmaceutici S.P.A. IL-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
US10660909B2 (en) * 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists

Also Published As

Publication number Publication date
PT3700514T (pt) 2025-05-26
AU2018356497B2 (en) 2024-02-29
DK3700514T3 (da) 2025-05-26
US20210361627A1 (en) 2021-11-25
SG11202003622TA (en) 2020-05-28
RS66852B1 (sr) 2025-06-30
MA50449A (fr) 2020-09-02
EP4548916A1 (en) 2025-05-07
ES3029183T3 (en) 2025-06-23
AU2018356497A1 (en) 2020-06-11
KR102766122B1 (ko) 2025-02-10
WO2019081470A1 (en) 2019-05-02
IL274031B2 (en) 2023-06-01
KR20230156797A (ko) 2023-11-14
US11660291B2 (en) 2023-05-30
HRP20250641T1 (hr) 2025-07-18
EP3700514B1 (en) 2025-03-19
MD3700514T2 (ro) 2025-08-31
KR20200091405A (ko) 2020-07-30
US20230248704A1 (en) 2023-08-10
EP3700514A1 (en) 2020-09-02
SI3700514T1 (sl) 2025-07-31
HUE071855T2 (hu) 2025-09-28
EP3476390A1 (en) 2019-05-01
LT3700514T (lt) 2025-06-10
JP2021500413A (ja) 2021-01-07
RU2020116757A (ru) 2021-11-30
JP2023164916A (ja) 2023-11-14
FI3700514T3 (fi) 2025-05-23
SMT202500202T1 (it) 2025-07-22
BR112020007940A2 (pt) 2020-10-20
RU2020116757A3 (pl) 2021-11-30
IL274031A (en) 2020-06-30
CA3079781A1 (en) 2019-05-02

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