PL3606929T3 - Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania - Google Patents
Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzaniaInfo
- Publication number
- PL3606929T3 PL3606929T3 PL18781797T PL18781797T PL3606929T3 PL 3606929 T3 PL3606929 T3 PL 3606929T3 PL 18781797 T PL18781797 T PL 18781797T PL 18781797 T PL18781797 T PL 18781797T PL 3606929 T3 PL3606929 T3 PL 3606929T3
- Authority
- PL
- Poland
- Prior art keywords
- beta
- preparation
- methods
- nicotinate ester
- nucleotides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762481912P | 2017-04-05 | 2017-04-05 | |
| EP18781797.8A EP3606929B1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
| PCT/US2018/026209 WO2018187540A1 (en) | 2017-04-05 | 2018-04-05 | Beta-nicotinate ester nucleotides and processes for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3606929T3 true PL3606929T3 (pl) | 2021-12-27 |
Family
ID=63712318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18781797T PL3606929T3 (pl) | 2017-04-05 | 2018-04-05 | Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10961268B2 (pl) |
| EP (1) | EP3606929B1 (pl) |
| JP (1) | JP7182289B2 (pl) |
| KR (1) | KR102605369B1 (pl) |
| CN (1) | CN110709406B (pl) |
| AU (2) | AU2018250242B2 (pl) |
| CA (1) | CA3059228C (pl) |
| CY (1) | CY1124450T1 (pl) |
| DK (1) | DK3606929T3 (pl) |
| ES (1) | ES2887224T3 (pl) |
| HR (1) | HRP20211296T1 (pl) |
| HU (1) | HUE055521T2 (pl) |
| LT (1) | LT3606929T (pl) |
| PL (1) | PL3606929T3 (pl) |
| PT (1) | PT3606929T (pl) |
| RS (1) | RS62284B1 (pl) |
| SI (1) | SI3606929T1 (pl) |
| SM (1) | SMT202100496T1 (pl) |
| WO (1) | WO2018187540A1 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3730507A1 (en) | 2005-11-18 | 2020-10-28 | Cornell Research Foundation, Inc. | Nicotinoyl riboside and nicotinamide riboside compositions for use in reducing toxicity induced by hmg-coa reductase inhibitors |
| PT3331894T (pt) | 2015-08-05 | 2021-04-07 | Metro Int Biotech Llc | Derivados mononucleotídicos de nicotinamida e suas utilizações |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| JP7182289B2 (ja) | 2017-04-05 | 2022-12-02 | コーネル ユニヴァーシティー | β－ニコチネートエステルヌクレオチドおよびその調製プロセス |
| US20210388018A1 (en) * | 2018-10-01 | 2021-12-16 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
| KR102060374B1 (ko) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| CN117545488A (zh) * | 2021-05-27 | 2024-02-09 | 麦德龙国际生物科技有限责任公司 | 烟酸单核苷酸及其酯的结晶固体以及其制作和使用方法 |
| CN113527376A (zh) * | 2021-08-06 | 2021-10-22 | 上海昶法新材料有限公司 | β-烟酰胺单核苷酸的制备方法 |
| JP2025500336A (ja) | 2021-12-22 | 2025-01-09 | メトロ インターナショナル バイオテック，エルエルシー | 炎症を治療するための組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3736314A (en) | 1967-06-02 | 1973-05-29 | Syntex Corp | Unsaturated nucleoside phosphonates phosphonic acids and phosphonic acid salts |
| EP3730507A1 (en) | 2005-11-18 | 2020-10-28 | Cornell Research Foundation, Inc. | Nicotinoyl riboside and nicotinamide riboside compositions for use in reducing toxicity induced by hmg-coa reductase inhibitors |
| WO2011003018A2 (en) | 2009-07-01 | 2011-01-06 | Cornell University | Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof |
| WO2011081945A2 (en) | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt6 |
| WO2011081942A1 (en) | 2009-12-14 | 2011-07-07 | Cornell University | Activation and activators of sirt5 |
| WO2011146636A2 (en) | 2010-05-18 | 2011-11-24 | Cornell University | Reagents and methods for sirtuin capture |
| WO2014014828A1 (en) | 2012-07-16 | 2014-01-23 | Cornell University | Nicotinamide riboside to treat hearing loss |
| JP6559713B2 (ja) * | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
| US20160035539A1 (en) | 2014-07-30 | 2016-02-04 | Lauri SAINIEMI | Microfabrication |
| US10525070B2 (en) | 2015-02-10 | 2020-01-07 | Duke University | Method of treating heart failure |
| CN107613990B (zh) | 2015-03-27 | 2021-03-26 | 康奈尔大学 | 烟酰胺单核苷酸的有效合成 |
| US20160355539A1 (en) * | 2015-06-04 | 2016-12-08 | Chromadex, Inc. | Selective solvent free phosphorylation |
| EP3322419B1 (en) | 2015-07-15 | 2025-09-03 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| JP7182289B2 (ja) | 2017-04-05 | 2022-12-02 | コーネル ユニヴァーシティー | β－ニコチネートエステルヌクレオチドおよびその調製プロセス |
| US20210388018A1 (en) | 2018-10-01 | 2021-12-16 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
-
2018
- 2018-04-05 JP JP2019555021A patent/JP7182289B2/ja active Active
- 2018-04-05 AU AU2018250242A patent/AU2018250242B2/en active Active
- 2018-04-05 PT PT187817978T patent/PT3606929T/pt unknown
- 2018-04-05 LT LTEPPCT/US2018/026209T patent/LT3606929T/lt unknown
- 2018-04-05 ES ES18781797T patent/ES2887224T3/es active Active
- 2018-04-05 DK DK18781797.8T patent/DK3606929T3/da active
- 2018-04-05 PL PL18781797T patent/PL3606929T3/pl unknown
- 2018-04-05 RS RS20211045A patent/RS62284B1/sr unknown
- 2018-04-05 HU HUE18781797A patent/HUE055521T2/hu unknown
- 2018-04-05 KR KR1020197032663A patent/KR102605369B1/ko active Active
- 2018-04-05 SI SI201830363T patent/SI3606929T1/sl unknown
- 2018-04-05 WO PCT/US2018/026209 patent/WO2018187540A1/en not_active Ceased
- 2018-04-05 CN CN201880036949.3A patent/CN110709406B/zh active Active
- 2018-04-05 SM SM20210496T patent/SMT202100496T1/it unknown
- 2018-04-05 CA CA3059228A patent/CA3059228C/en active Active
- 2018-04-05 HR HRP20211296TT patent/HRP20211296T1/hr unknown
- 2018-04-05 US US16/603,164 patent/US10961268B2/en active Active
- 2018-04-05 EP EP18781797.8A patent/EP3606929B1/en active Active
-
2021
- 2021-03-29 US US17/216,533 patent/US11530233B2/en active Active
- 2021-08-19 CY CY20211100746T patent/CY1124450T1/el unknown
- 2021-10-15 AU AU2021250984A patent/AU2021250984B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SI3606929T1 (sl) | 2021-11-30 |
| US11530233B2 (en) | 2022-12-20 |
| JP2020516619A (ja) | 2020-06-11 |
| CA3059228A1 (en) | 2018-10-11 |
| EP3606929A1 (en) | 2020-02-12 |
| AU2018250242A1 (en) | 2019-10-31 |
| AU2021250984B2 (en) | 2022-09-01 |
| CY1124450T1 (el) | 2022-07-22 |
| KR20190137133A (ko) | 2019-12-10 |
| US20210214386A1 (en) | 2021-07-15 |
| WO2018187540A1 (en) | 2018-10-11 |
| AU2018250242B2 (en) | 2021-07-15 |
| RS62284B1 (sr) | 2021-09-30 |
| US20200031860A1 (en) | 2020-01-30 |
| CN110709406A (zh) | 2020-01-17 |
| KR102605369B1 (ko) | 2023-11-24 |
| JP7182289B2 (ja) | 2022-12-02 |
| EP3606929B1 (en) | 2021-06-02 |
| US10961268B2 (en) | 2021-03-30 |
| CN110709406B (zh) | 2022-11-08 |
| EP3606929A4 (en) | 2020-05-06 |
| HUE055521T2 (hu) | 2021-11-29 |
| DK3606929T3 (da) | 2021-08-23 |
| SMT202100496T1 (it) | 2021-11-12 |
| HRP20211296T1 (hr) | 2021-11-12 |
| AU2021250984A1 (en) | 2021-11-18 |
| CA3059228C (en) | 2025-03-18 |
| ES2887224T3 (es) | 2021-12-22 |
| LT3606929T (lt) | 2021-10-25 |
| PT3606929T (pt) | 2021-09-02 |
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