HUE055521T2 - Béta-nikotinát-észter nukleotidok és eljárás azok elõállítására - Google Patents

Béta-nikotinát-észter nukleotidok és eljárás azok elõállítására

Info

Publication number
HUE055521T2
HUE055521T2 HUE18781797A HUE18781797A HUE055521T2 HU E055521 T2 HUE055521 T2 HU E055521T2 HU E18781797 A HUE18781797 A HU E18781797A HU E18781797 A HUE18781797 A HU E18781797A HU E055521 T2 HUE055521 T2 HU E055521T2
Authority
HU
Hungary
Prior art keywords
beta
processes
preparing same
nicotinate ester
nucleotides
Prior art date
Application number
HUE18781797A
Other languages
English (en)
Inventor
Anthony A Sauve
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of HUE055521T2 publication Critical patent/HUE055521T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
HUE18781797A 2017-04-05 2018-04-05 Béta-nikotinát-észter nukleotidok és eljárás azok elõállítására HUE055521T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762481912P 2017-04-05 2017-04-05

Publications (1)

Publication Number Publication Date
HUE055521T2 true HUE055521T2 (hu) 2021-11-29

Family

ID=63712318

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18781797A HUE055521T2 (hu) 2017-04-05 2018-04-05 Béta-nikotinát-észter nukleotidok és eljárás azok elõállítására

Country Status (18)

Country Link
US (2) US10961268B2 (hu)
EP (1) EP3606929B1 (hu)
JP (1) JP7182289B2 (hu)
KR (1) KR102605369B1 (hu)
CN (1) CN110709406B (hu)
AU (2) AU2018250242B2 (hu)
CA (1) CA3059228A1 (hu)
CY (1) CY1124450T1 (hu)
DK (1) DK3606929T3 (hu)
ES (1) ES2887224T3 (hu)
HR (1) HRP20211296T1 (hu)
HU (1) HUE055521T2 (hu)
LT (1) LT3606929T (hu)
PL (1) PL3606929T3 (hu)
PT (1) PT3606929T (hu)
RS (1) RS62284B1 (hu)
SI (1) SI3606929T1 (hu)
WO (1) WO2018187540A1 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3369738B1 (en) 2005-11-18 2020-05-20 Cornell Research Foundation, Inc. Method for making nicotinoyl ribosides and nicotinamide beta-riboside
CA2994553C (en) 2015-08-05 2022-08-30 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
CN110709406B (zh) 2017-04-05 2022-11-08 康奈尔大学 β-烟酸酯核苷酸及其制备方法
WO2020072497A1 (en) * 2018-10-01 2020-04-09 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
EP4346842A1 (en) * 2021-05-27 2024-04-10 Metro International Biotech, LLC Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
CN113527376A (zh) * 2021-08-06 2021-10-22 上海昶法新材料有限公司 β-烟酰胺单核苷酸的制备方法
WO2023122190A1 (en) * 2021-12-22 2023-06-29 Metro International Biotech, Llc Compositions for treatment of inflammation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736314A (en) * 1967-06-02 1973-05-29 Syntex Corp Unsaturated nucleoside phosphonates phosphonic acids and phosphonic acid salts
EP3369738B1 (en) 2005-11-18 2020-05-20 Cornell Research Foundation, Inc. Method for making nicotinoyl ribosides and nicotinamide beta-riboside
WO2011003018A2 (en) 2009-07-01 2011-01-06 Cornell University Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof
WO2011081945A2 (en) 2009-12-14 2011-07-07 Cornell University Activation and activators of sirt6
US9603862B2 (en) 2009-12-14 2017-03-28 Cornell University Activation and activators of SIRT5
WO2011146636A2 (en) 2010-05-18 2011-11-24 Cornell University Reagents and methods for sirtuin capture
WO2014014828A1 (en) 2012-07-16 2014-01-23 Cornell University Nicotinamide riboside to treat hearing loss
WO2015186114A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
US20160035539A1 (en) * 2014-07-30 2016-02-04 Lauri SAINIEMI Microfabrication
US10525070B2 (en) 2015-02-10 2020-01-07 Duke University Method of treating heart failure
US10590160B2 (en) 2015-03-27 2020-03-17 Cornell University Efficient synthesis of nicotinamide mononucleotide
CN107846883A (zh) * 2015-06-04 2018-03-27 可劳迈戴斯有限公司 选择性无溶剂磷酸化
EP3322419A4 (en) 2015-07-15 2018-08-01 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
CN110709406B (zh) 2017-04-05 2022-11-08 康奈尔大学 β-烟酸酯核苷酸及其制备方法
WO2020072497A1 (en) 2018-10-01 2020-04-09 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof

Also Published As

Publication number Publication date
EP3606929B1 (en) 2021-06-02
PL3606929T3 (pl) 2021-12-27
HRP20211296T1 (hr) 2021-11-12
DK3606929T3 (da) 2021-08-23
US20200031860A1 (en) 2020-01-30
JP7182289B2 (ja) 2022-12-02
PT3606929T (pt) 2021-09-02
EP3606929A1 (en) 2020-02-12
CN110709406A (zh) 2020-01-17
US11530233B2 (en) 2022-12-20
AU2018250242B2 (en) 2021-07-15
KR20190137133A (ko) 2019-12-10
AU2021250984A1 (en) 2021-11-18
JP2020516619A (ja) 2020-06-11
KR102605369B1 (ko) 2023-11-24
WO2018187540A1 (en) 2018-10-11
US20210214386A1 (en) 2021-07-15
US10961268B2 (en) 2021-03-30
SI3606929T1 (sl) 2021-11-30
CA3059228A1 (en) 2018-10-11
CY1124450T1 (el) 2022-07-22
AU2021250984B2 (en) 2022-09-01
CN110709406B (zh) 2022-11-08
EP3606929A4 (en) 2020-05-06
AU2018250242A1 (en) 2019-10-31
ES2887224T3 (es) 2021-12-22
RS62284B1 (sr) 2021-09-30
LT3606929T (lt) 2021-10-25

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