PL359174A1 - Polimery amfifilowe oraz ich koniugaty z polipeptydami - Google Patents

Polimery amfifilowe oraz ich koniugaty z polipeptydami

Info

Publication number
PL359174A1
PL359174A1 PL00359174A PL35917400A PL359174A1 PL 359174 A1 PL359174 A1 PL 359174A1 PL 00359174 A PL00359174 A PL 00359174A PL 35917400 A PL35917400 A PL 35917400A PL 359174 A1 PL359174 A1 PL 359174A1
Authority
PL
Poland
Prior art keywords
same
amphiphilic polymers
polypeptide conjugates
conjugates
polypeptide
Prior art date
Application number
PL00359174A
Other languages
English (en)
Inventor
Nnochiri N. Ekwuribe
Original Assignee
Nobex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corporation filed Critical Nobex Corporation
Publication of PL359174A1 publication Critical patent/PL359174A1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
PL00359174A 1999-12-13 2000-12-11 Polimery amfifilowe oraz ich koniugaty z polipeptydami PL359174A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/459,443 US6638906B1 (en) 1999-12-13 1999-12-13 Amphiphilic polymers and polypeptide conjugates comprising same

Publications (1)

Publication Number Publication Date
PL359174A1 true PL359174A1 (pl) 2004-08-23

Family

ID=23824795

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00359174A PL359174A1 (pl) 1999-12-13 2000-12-11 Polimery amfifilowe oraz ich koniugaty z polipeptydami

Country Status (18)

Country Link
US (2) US6638906B1 (pl)
EP (1) EP1237580A2 (pl)
JP (1) JP2003516366A (pl)
KR (1) KR20020068053A (pl)
CN (1) CN1434725A (pl)
AU (1) AU2087501A (pl)
BR (1) BR0016339A (pl)
CA (1) CA2394928A1 (pl)
CZ (1) CZ20021990A3 (pl)
HK (1) HK1049283A1 (pl)
HU (1) HUP0300133A2 (pl)
IL (1) IL150119A0 (pl)
MX (1) MXPA02005885A (pl)
NO (1) NO20022793L (pl)
PL (1) PL359174A1 (pl)
RU (1) RU2002118709A (pl)
WO (1) WO2001041812A2 (pl)
ZA (1) ZA200204603B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20090281023A9 (en) * 2001-06-04 2009-11-12 Nobex Corporation Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment
US8110351B2 (en) 2002-01-16 2012-02-07 Invitrogen Dynal As Method for isolating nucleic acids and protein from a single sample
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
CA2504287A1 (en) * 2002-11-26 2004-06-10 Nobex Corporation Natriuretic compounds, conjugates, and uses thereof
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
US20060241051A1 (en) 2002-12-26 2006-10-26 Chieko Kitada Metastin derivatives and use thereof
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
JP2007509982A (ja) * 2003-10-29 2007-04-19 アルタス ファーマシューティカルズ インコーポレイテッド 血漿コレシストキニン（ｃｃｋ）濃度を制御するための非膵臓プロテアーゼおよび痛みを処置するための非膵臓プロテアーゼ
JP4346650B2 (ja) 2004-06-25 2009-10-21 武田薬品工業株式会社 メタスチン誘導体およびその用途
US8329958B2 (en) 2004-07-02 2012-12-11 Biocon Limited Combinatorial synthesis of PEG oligomer libraries
US8168222B2 (en) * 2004-09-07 2012-05-01 Board Of Regents Of The University Of Nebraska Amphiphilic polymer-protein conjugates and methods of use thereof
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US8349991B2 (en) * 2005-04-19 2013-01-08 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
US20070026383A1 (en) * 2005-07-15 2007-02-01 Quintessence Biosciences, Inc. Methods and compositions for extracting membrane proteins
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI404726B (zh) 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
SI2314609T1 (sl) * 2008-07-30 2017-05-31 Takeda Pharmaceutical Company Limited Derivat metastina in njegova uporaba
CN103517918A (zh) * 2011-03-01 2014-01-15 诺沃—诺迪斯克有限公司 拮抗性dr3配体
CN103740661B (zh) * 2012-05-10 2015-06-03 江南大学 一种提高酶热稳定性的方法
CN103740659B (zh) * 2012-05-10 2015-06-03 江南大学 一种提高酶热稳定性的方法
US20140039158A1 (en) * 2012-07-25 2014-02-06 Belrose Pharma, Inc. Polymeric conjugates and methods of preparing the same
CN106729735B (zh) * 2017-03-09 2020-05-12 国家纳米科学中心 一种pH敏感的多肽聚合物及其制备方法和应用
WO2019201894A1 (en) * 2018-04-16 2019-10-24 Merck Patent Gmbh Additives for protein formulations to improve thermal stability
KR102765361B1 (ko) * 2022-08-22 2025-02-11 부산대학교 산학협력단 폴리소르베이트-숙신산-카르니틴 복합체 및 이를 포함하는 생리활성 물질 또는 약물 전달용 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5407683A (en) 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6191105B1 (en) 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
EP0862631A1 (en) 1995-10-26 1998-09-09 The Board Of Regents, The University Of Texas System Luminal cholecystokinin-releasing factor
PL189698B1 (pl) 1996-03-12 2005-09-30 Pg Txl Co Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
IL133585A0 (en) 1997-06-20 2001-04-30 Baker Norton Pharma Soluble prodrugs of paclitaxel
US6495514B1 (en) * 1998-01-21 2002-12-17 Mercer University Method for reducing inflammation and inducing an analgesic effect and compounds thereof
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
KR100345214B1 (ko) * 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Also Published As

Publication number Publication date
CZ20021990A3 (cs) 2002-11-13
CN1434725A (zh) 2003-08-06
EP1237580A2 (en) 2002-09-11
CA2394928A1 (en) 2001-06-14
AU2087501A (en) 2001-06-18
RU2002118709A (ru) 2004-02-27
IL150119A0 (en) 2002-12-01
WO2001041812A2 (en) 2001-06-14
MXPA02005885A (es) 2002-10-23
JP2003516366A (ja) 2003-05-13
HUP0300133A2 (en) 2003-05-28
NO20022793L (no) 2002-08-13
ZA200204603B (en) 2003-11-26
NO20022793D0 (no) 2002-06-12
US20040092449A1 (en) 2004-05-13
BR0016339A (pt) 2002-08-27
US6638906B1 (en) 2003-10-28
KR20020068053A (ko) 2002-08-24
HK1049283A1 (zh) 2003-05-09
WO2001041812A3 (en) 2002-03-21

Similar Documents

Publication Publication Date Title
IL150119A0 (en) Amphiphilic polymers and polypeptide conjugates comprising same
GB0004544D0 (en) Polymers their preparation and uses
EG22873A (en) Novel copolymers and films thereof
ZA9811590B (en) Interferon polymer conjugates
EP1157110A4 (en) NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT
AU1540001A (en) Fluorene-perylene copolymers and uses thereof
AU7223998A (en) Polymers and their preparation
GB9905203D0 (en) Polymer preparation
GB9920774D0 (en) Polymer
GB9919764D0 (en) Thyristors and their manufacture
GB9806806D0 (en) Peptides and uses thereof
AUPQ342599A0 (en) Conjugates and uses thereof
AU2841801A (en) Triazolotriazinones and the use thereof
IL131707A0 (en) Acetylcholinesterase-derived peptides and uses thereof
GB0026240D0 (en) Polymers and their uses
PL346758A1 (en) Phosphorylated polymers and conjugates thereof
IL131266A0 (en) Peptides and pharmaceutical compositions comprising same
GB9810372D0 (en) Polymers and their uses
GB2364062B (en) Polymers from diaminoanthracene and anthraquinone
GB9917165D0 (en) Polypeptides polynuclcotides and uses thereof
AU5979300A (en) Angiopoietin-6 and uses thereof
GB2348882B (en) Polymer compositions and their uses
GB9927205D0 (en) Novel copolymers and films thereof
GB9930708D0 (en) MUS101 and homologues thereof
IL149638A0 (en) S-allylmercaptoglutathione and uses thereof