PL3532059T3 - Terapia skojarzona z zastosowaniem inhibitora białka bet - Google Patents
Terapia skojarzona z zastosowaniem inhibitora białka betInfo
- Publication number
- PL3532059T3 PL3532059T3 PL17864117T PL17864117T PL3532059T3 PL 3532059 T3 PL3532059 T3 PL 3532059T3 PL 17864117 T PL17864117 T PL 17864117T PL 17864117 T PL17864117 T PL 17864117T PL 3532059 T3 PL3532059 T3 PL 3532059T3
- Authority
- PL
- Poland
- Prior art keywords
- bromodomain
- extra
- combination therapy
- protein inhibitor
- terminal protein
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title 1
- 108050009021 Bromodomains Proteins 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 229940121649 protein inhibitor Drugs 0.000 title 1
- 239000012268 protein inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413763P | 2016-10-27 | 2016-10-27 | |
| US201762560840P | 2017-09-20 | 2017-09-20 | |
| PCT/US2017/058614 WO2018081475A1 (en) | 2016-10-27 | 2017-10-26 | Bromodomain and extra-terminal protein inhibitor combination therapy |
| EP17864117.1A EP3532059B1 (en) | 2016-10-27 | 2017-10-26 | Bromodomain and extra-terminal protein inhibitor combination therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3532059T3 true PL3532059T3 (pl) | 2022-05-09 |
Family
ID=62019758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17864117T PL3532059T3 (pl) | 2016-10-27 | 2017-10-26 | Terapia skojarzona z zastosowaniem inhibitora białka bet |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10166227B2 (pl) |
| EP (1) | EP3532059B1 (pl) |
| JP (1) | JP7171557B2 (pl) |
| KR (2) | KR102528406B1 (pl) |
| AU (1) | AU2017347853B2 (pl) |
| CA (1) | CA3041049A1 (pl) |
| CY (1) | CY1125126T1 (pl) |
| DK (1) | DK3532059T3 (pl) |
| ES (1) | ES2907840T3 (pl) |
| HR (1) | HRP20220375T1 (pl) |
| HU (1) | HUE058289T2 (pl) |
| LT (1) | LT3532059T (pl) |
| PL (1) | PL3532059T3 (pl) |
| PT (1) | PT3532059T (pl) |
| RS (1) | RS63054B1 (pl) |
| SI (1) | SI3532059T1 (pl) |
| SM (1) | SMT202200135T1 (pl) |
| TW (1) | TW201821106A (pl) |
| WO (1) | WO2018081475A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10702517B2 (en) * | 2015-04-22 | 2020-07-07 | Celgene Quanticel Research, Inc. | Bromodomain inhibitor |
| KR102528406B1 (ko) | 2016-10-27 | 2023-05-03 | 셀젠 콴티셀 리서치, 인크. | 브로모도메인 및 엑스트라-말단 단백질 억제제 병용 치료요법 |
| WO2019204758A1 (en) * | 2018-04-20 | 2019-10-24 | Zhiguo Zhang | Compositions and methods for treating glioblastoma by modulating a mgmt enhancer |
| CN110211633B (zh) * | 2019-05-06 | 2021-08-31 | 臻和精准医学检验实验室无锡有限公司 | Mgmt基因启动子甲基化的检测方法、测序数据的处理方法及处理装置 |
| CA3148504A1 (en) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Combination therapy for treatment of cancer |
| AU2022387426A1 (en) * | 2021-11-10 | 2024-05-16 | Celgene Quanticel Research, Inc. | Bet inhibitor for treating glioblastoma |
| WO2024050016A1 (en) | 2022-08-31 | 2024-03-07 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
| WO2024148225A1 (en) * | 2023-01-05 | 2024-07-11 | Ks And Associates Llc, Doing Business As Dream Tech, Llc | Method and system for prior toxicity data informed dose-response modeling and benchmark dose (bmd) estimation |
| WO2025049555A1 (en) | 2023-08-31 | 2025-03-06 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| GB8616125D0 (en) | 1986-07-02 | 1986-08-06 | May & Baker Ltd | Compositions of matter |
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| GB9601603D0 (en) | 1996-01-26 | 1996-03-27 | Isis Innovations Ltd | Terpyridine-platinum (II) complexes |
| CN101220033A (zh) | 2001-01-18 | 2008-07-16 | 先灵公司 | 替莫唑胺和类似物的合成 |
| DE102006007309B4 (de) | 2005-02-17 | 2012-11-29 | Chemagis Ltd. | Verbessertes Verfahren zur Herstellung von Temozolomid |
| US20070166388A1 (en) | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| JP5199263B2 (ja) | 2006-09-29 | 2013-05-15 | シプラ・リミテッド | テモゾロミドと類似体を調製するための改善された方法 |
| DE102008034256A1 (de) | 2008-07-18 | 2010-01-21 | Technische Universität Dresden | Photoaktives Bauelement mit organischen Schichten |
| US9073878B2 (en) * | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| AU2013365926B9 (en) * | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| BR112015022674A2 (pt) * | 2013-03-11 | 2017-07-18 | Abbvie Inc | inibidores de bromodomínio |
| TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
| CA2915838C (en) * | 2013-06-21 | 2023-04-18 | Zenith Epigenetics Corp. | Bicyclic bromodomain inhibitors |
| WO2015018522A1 (en) * | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl) |
| EP3290407B1 (en) * | 2013-10-18 | 2020-01-01 | Celgene Quanticel Research, Inc | Bromodomain inhibitors |
| CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2016014859A1 (en) * | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
| US20190055235A1 (en) * | 2014-12-17 | 2019-02-21 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
| TW201642860A (zh) * | 2015-04-22 | 2016-12-16 | 塞爾基因定量細胞研究公司 | 布羅莫結構域抑制劑 |
| SG10202013249PA (en) * | 2015-12-24 | 2021-02-25 | Celgene Quanticel Research Inc | Bromodomain and extra-terminal protein inhibitor combination therapy |
| KR102528406B1 (ko) * | 2016-10-27 | 2023-05-03 | 셀젠 콴티셀 리서치, 인크. | 브로모도메인 및 엑스트라-말단 단백질 억제제 병용 치료요법 |
-
2017
- 2017-10-26 KR KR1020197014146A patent/KR102528406B1/ko active Active
- 2017-10-26 CA CA3041049A patent/CA3041049A1/en active Pending
- 2017-10-26 AU AU2017347853A patent/AU2017347853B2/en active Active
- 2017-10-26 HR HRP20220375TT patent/HRP20220375T1/hr unknown
- 2017-10-26 SI SI201731079T patent/SI3532059T1/sl unknown
- 2017-10-26 KR KR1020237014461A patent/KR102587839B1/ko active Active
- 2017-10-26 JP JP2019522408A patent/JP7171557B2/ja active Active
- 2017-10-26 ES ES17864117T patent/ES2907840T3/es active Active
- 2017-10-26 WO PCT/US2017/058614 patent/WO2018081475A1/en not_active Ceased
- 2017-10-26 RS RS20220280A patent/RS63054B1/sr unknown
- 2017-10-26 DK DK17864117.1T patent/DK3532059T3/da active
- 2017-10-26 LT LTEPPCT/US2017/058614T patent/LT3532059T/lt unknown
- 2017-10-26 PL PL17864117T patent/PL3532059T3/pl unknown
- 2017-10-26 SM SM20220135T patent/SMT202200135T1/it unknown
- 2017-10-26 PT PT178641171T patent/PT3532059T/pt unknown
- 2017-10-26 HU HUE17864117A patent/HUE058289T2/hu unknown
- 2017-10-26 EP EP17864117.1A patent/EP3532059B1/en active Active
- 2017-10-27 TW TW106137075A patent/TW201821106A/zh unknown
- 2017-10-27 US US15/796,571 patent/US10166227B2/en active Active
-
2018
- 2018-11-14 US US16/191,319 patent/US10576075B2/en active Active
-
2020
- 2020-01-23 US US16/750,996 patent/US10881655B2/en active Active
- 2020-09-25 US US17/033,311 patent/US11464771B2/en active Active
-
2022
- 2022-03-21 CY CY20221100226T patent/CY1125126T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018081475A1 (en) | 2018-05-03 |
| US20210008056A1 (en) | 2021-01-14 |
| EP3532059B1 (en) | 2022-01-26 |
| HUE058289T2 (hu) | 2022-07-28 |
| US10166227B2 (en) | 2019-01-01 |
| US10576075B2 (en) | 2020-03-03 |
| PT3532059T (pt) | 2022-03-02 |
| TW201821106A (zh) | 2018-06-16 |
| HRP20220375T1 (hr) | 2022-05-13 |
| RS63054B1 (sr) | 2022-04-29 |
| EP3532059A4 (en) | 2020-05-20 |
| KR20190088979A (ko) | 2019-07-29 |
| US11464771B2 (en) | 2022-10-11 |
| LT3532059T (lt) | 2022-05-25 |
| JP2019535682A (ja) | 2019-12-12 |
| CA3041049A1 (en) | 2018-05-03 |
| US20180117030A1 (en) | 2018-05-03 |
| CY1125126T1 (el) | 2023-06-09 |
| ES2907840T3 (es) | 2022-04-26 |
| EP3532059A1 (en) | 2019-09-04 |
| US10881655B2 (en) | 2021-01-05 |
| US20200155539A1 (en) | 2020-05-21 |
| KR102587839B1 (ko) | 2023-10-11 |
| SI3532059T1 (sl) | 2022-06-30 |
| AU2017347853B2 (en) | 2022-02-17 |
| JP7171557B2 (ja) | 2022-11-15 |
| SMT202200135T1 (it) | 2022-05-12 |
| KR102528406B1 (ko) | 2023-05-03 |
| KR20230078758A (ko) | 2023-06-02 |
| DK3532059T3 (da) | 2022-03-14 |
| AU2017347853A1 (en) | 2019-05-30 |
| US20190083483A1 (en) | 2019-03-21 |
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