PL339342A1 - Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2 - Google Patents

Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2

Info

Publication number
PL339342A1
PL339342A1 PL98339342A PL33934298A PL339342A1 PL 339342 A1 PL339342 A1 PL 339342A1 PL 98339342 A PL98339342 A PL 98339342A PL 33934298 A PL33934298 A PL 33934298A PL 339342 A1 PL339342 A1 PL 339342A1
Authority
PL
Poland
Prior art keywords
inhibitor
opioidic
antaligic
synergetically
oxygenase
Prior art date
Application number
PL98339342A
Other versions
PL191966B1 (en
Original Assignee
Euro Celtique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique filed Critical Euro Celtique
Publication of PL339342A1 publication Critical patent/PL339342A1/en
Publication of PL191966B1 publication Critical patent/PL191966B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention relates to the use of a combination of an opioid analgesic together with a COX-2 inhibitor. <IMAGE>
PL339342A 1997-09-17 1998-09-17 Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2 PL191966B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5919597P 1997-09-17 1997-09-17
PCT/US1998/019516 WO1999013799A1 (en) 1997-09-17 1998-09-17 Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor

Publications (2)

Publication Number Publication Date
PL339342A1 true PL339342A1 (en) 2000-12-18
PL191966B1 PL191966B1 (en) 2006-07-31

Family

ID=22021415

Family Applications (1)

Application Number Title Priority Date Filing Date
PL339342A PL191966B1 (en) 1997-09-17 1998-09-17 Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2

Country Status (26)

Country Link
US (11) US6552031B1 (en)
EP (2) EP1014886B1 (en)
JP (1) JP5077903B2 (en)
KR (1) KR100444195B1 (en)
CN (1) CN1241567C (en)
AT (2) ATE283051T1 (en)
AU (1) AU742097B2 (en)
BR (1) BR9812342A (en)
CA (1) CA2303309C (en)
CY (2) CY1106044T1 (en)
CZ (1) CZ300531B6 (en)
DE (2) DE69841590D1 (en)
DK (1) DK1518555T3 (en)
ES (2) ES2235365T3 (en)
HU (2) HU227855B1 (en)
IL (1) IL134987A0 (en)
NO (2) NO325884B1 (en)
NZ (2) NZ503233A (en)
PL (1) PL191966B1 (en)
PT (2) PT1518555E (en)
RS (1) RS49982B (en)
RU (1) RU2232600C2 (en)
SI (1) SI1518555T1 (en)
TR (1) TR200001041T2 (en)
UA (1) UA72193C2 (en)
WO (1) WO1999013799A1 (en)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
RS49982B (en) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor
WO2000029022A1 (en) * 1998-11-12 2000-05-25 Algos Pharmaceutical Corporation Cox-2 inhibitors in combination with centrally acting analgesics
SA99191255B1 (en) * 1998-11-30 2006-11-25 جي دي سيرل اند كو celecoxib compounds
JP2002538176A (en) * 1999-03-01 2002-11-12 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Compositions comprising tramadol substances and selective COX-2 inhibitors
DE19927688A1 (en) * 1999-06-17 2000-12-21 Gruenenthal Gmbh Multi-layered tablet containing tramadole and diclofenac, useful for treating pain, has separating layer between active ingredient layers
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
GB9923738D0 (en) * 1999-10-07 1999-12-08 Nestle Sa Nutritional composition
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
CA2389235C (en) 1999-10-29 2007-07-17 Euro-Celtique, S.A. Controlled release hydrocodone formulations
ECSP003851A (en) * 1999-12-22 2002-05-23 Pharmacia Corp DOUBLE RELEASE COMPOSITION OF A CYCLLOXYGENASA-2 INHIBITOR
BR0108379A (en) * 2000-02-08 2002-11-05 Euro Celtique Sa Controlled release compositions containing opioid agonist and antagonist, method for preparing a controlled release opioid analgesic formulation with increased analgesic potency and delivery system through the dermis for an opioid analgesic
DE10025948A1 (en) * 2000-05-26 2001-11-29 Gruenenthal Gmbh drug combination
EA200802070A1 (en) 2000-06-13 2009-06-30 Вайет ANALYSIS AND ANTI-INFLAMMATORY COMPOSITIONS CONTAINING CYCLOOXIGASE-2 INHIBITORS
US20020035107A1 (en) 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
US20040033938A1 (en) * 2000-09-12 2004-02-19 Britten Nancy J. Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US7071220B2 (en) * 2000-09-18 2006-07-04 Toa Eiyo Ltd. N-substituted benzothiophenesulfonamide derivatives
KR100968128B1 (en) 2000-10-30 2010-07-06 유로-셀티크 소시에떼 아노뉨 Sustained Release Hydrocodone Formulations
PT1349553E (en) * 2001-01-12 2007-01-31 Bsp Pharma As Dihydro-triterpenes in the treatment of viral infections, cardiovascular disease, inflammation, hypersensitivity or pain
MY137736A (en) * 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
US20040105883A1 (en) * 2001-04-17 2004-06-03 Ping Gao Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage
DE60230632D1 (en) * 2001-07-18 2009-02-12 Euro Celtique Sa PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE
CA2457361C (en) 2001-08-06 2008-11-04 Christopher Breder Opioid agonist formulations with releasable and sequestered antagonist
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
AR038957A1 (en) 2001-08-15 2005-02-02 Pharmacia Corp COMBINATION THERAPY FOR CANCER TREATMENT
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US7338971B2 (en) * 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
EP1448228A4 (en) * 2001-10-24 2007-01-24 Marco Pappagallo Management of postoperative pain
DE10161077A1 (en) * 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Highly concentrated stable meloxicam solutions for needleless injection
CN100418533C (en) * 2002-02-19 2008-09-17 阿德科克因格拉姆有限公司 Pharmaceutical combination of a cyclooxygenase-2 inhibitor and an opiate
GB0206505D0 (en) * 2002-03-19 2002-05-01 Euro Celtique Sa Pharmaceutical combination
US7666876B2 (en) 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
CN1674873A (en) * 2002-08-15 2005-09-28 欧罗赛铁克股份有限公司 Pharmaceutical compositions
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
DE10254785A1 (en) * 2002-11-22 2004-06-03 Grünenthal GmbH Synergistic mixture of analgesic and inhibitor of cyclo-oxygenase II, useful for treatment of pain, effective at low doses and with reduced side effects
DE50309605D1 (en) * 2002-11-22 2008-05-21 Gruenenthal Gmbh Use of (1RS, 3RS, 6RS) -6-dimethylaminomethyl-1- (3-methoxyphenyl) -cyclohexane-1,3-diol for the treatment of inflammatory pain
SI1575569T1 (en) 2002-12-13 2010-12-31 Durect Corp Oral drug delivery system comprising high viscosity liquid carrier materials
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
AU2004285327A1 (en) * 2003-10-21 2005-05-12 Arakis Ltd. The use of non-opiates for the potentation of opiates
EP1568369A1 (en) * 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
DE102004021281A1 (en) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
LT1765292T (en) 2004-06-12 2018-01-10 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
DE102004030409A1 (en) * 2004-06-23 2006-01-26 Boehringer Ingelheim Vetmedica Gmbh New use of meloxicam in veterinary medicine
US7226619B1 (en) * 2004-09-07 2007-06-05 Pharmorx Inc. Material for controlling diversion of medications
US20060281775A1 (en) 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
KR20080039400A (en) * 2005-07-07 2008-05-07 파남 컴퍼니스 인크. Sustained-release pharmaceutical composition of the high water-soluble drug
WO2007039417A1 (en) * 2005-09-30 2007-04-12 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical preparation containing meloxicam
RU2311179C1 (en) * 2006-02-20 2007-11-27 Дмитрий Владимирович Зимин Therapeutical agent possessing antiinflammatory, analgetic, and antipyretic properties and a method for preparation thereof
ES2516693T3 (en) * 2006-03-16 2014-10-31 Euro-Celtique S.A. Pharmaceutical spheroids
ITMI20060983A1 (en) * 2006-05-18 2007-11-19 Formevet S P A VETERINARY PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN AND INFLAMMATION
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
CN101484169A (en) * 2006-06-23 2009-07-15 依兰药物国际有限公司 Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
US8765178B2 (en) 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods
EP2068840A2 (en) * 2006-07-21 2009-06-17 LAB International SRL Hydrophobic abuse deterrent delivery system
US20080026053A1 (en) * 2006-07-28 2008-01-31 Sovereign Pharmaceuticals, Ltd. Capsule containing granular pharmaceutical compositions
WO2008091530A2 (en) * 2007-01-19 2008-07-31 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
US20080241121A1 (en) * 2007-04-02 2008-10-02 Daniela Salvemini Inhibitors of the ceramide metabolic pathway as adjuncts to opiates for pain
US20100086543A1 (en) * 2007-04-02 2010-04-08 Saint Louis University Compositions and methods for treating conditions associated with ceramide biosynthesis
US8415401B2 (en) 2007-12-06 2013-04-09 Durect Corporation Oral pharmaceutical dosage forms
US8771643B2 (en) 2008-01-04 2014-07-08 Schabar Research Associates Llc Use of analgesic potentiating compounds to potentiate the analgesic properties of an analgesic compound
US20090263489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Analgesic and anti-inflammatory compositions and methods for reducing, preventing or treating pain and inflammation
TWI473614B (en) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
CA2737257C (en) * 2008-09-18 2016-11-15 Purdue Pharma L.P. Pharmaceutical dosage forms comprising poly(.epsilon.-caprolactone)
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
JP5845173B2 (en) * 2009-05-01 2016-01-20 アデア ファーマスーティカルズ，インコーポレイテッド Orally disintegrating tablet composition comprising a combination of a non-opioid and an opioid analgesic
WO2011046853A1 (en) 2009-10-12 2011-04-21 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
EP2311446A1 (en) * 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
IT1398321B1 (en) * 2010-02-26 2013-02-22 Formevet Spa Ora Formevet Srl ASSOCIATION OF A CENTRAL ACTION ANALGESIC AND AN ANTI-INFLAMMATORY SELECTIVE INHIBITOR OF CYCLOOSOXIGENASIS 2 FOR THE TREATMENT OF INFLAMMATION AND PAIN IN THE VETERINARY FIELD
CA2791805A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
KR101647267B1 (en) 2010-12-22 2016-08-09 퍼듀 퍼머 엘피 Encased tamper resistant controlled release dosage forms
PH12013501345A1 (en) 2010-12-23 2022-10-24 Purdue Pharma Lp Tamper resistant solid oral dosage forms
RU2471491C1 (en) * 2011-10-19 2013-01-10 Станислав Анатольевич Кедик Use of n-vinylpyrrolidone copolymer as agent potentiating analgesic effect of morphine hydrochloride
US20130310435A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol
US20130310385A1 (en) 2012-05-18 2013-11-21 Gruenenthal Gmbh Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants
US9308196B2 (en) * 2012-05-18 2016-04-12 Gruenenthal Gmbh Pharmaceutical composition comprising (1 r,4r) -6'-fluoro-N ,N-dimethyl-4-phenyl-4',9'-d ihydro-3'H-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and an oxicam
US9320729B2 (en) 2012-05-18 2016-04-26 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative
US9855286B2 (en) 2012-05-18 2018-01-02 Gruenenthal Gmbh Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component
PE20151301A1 (en) 2013-02-05 2015-09-16 Purdue Pharma Lp PHARMACEUTICAL FORMULATIONS RESISTANT TO IMPROPER HANDLING
AU2014225685A1 (en) * 2013-03-07 2015-09-17 University Of Maryland, Baltimore Novel mixed mu agonist/ delta antagonist opioid analgesics with reduced tolerance liabilities and uses thereof
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CA2919892C (en) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
DK3169315T3 (en) 2014-07-17 2020-08-10 Pharmaceutical Manufacturing Res Services In Liquid-filled dosage form to prevent immediate release abuse
RU2745292C2 (en) 2014-09-15 2021-03-23 Орпхазиме А/C Composition with arimoclomol
JP2017531026A (en) 2014-10-20 2017-10-19 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド Sustained release abuse deterrent liquid filler form
KR101710792B1 (en) 2015-07-14 2017-02-28 주식회사 유영제약 Pharmaceutical compositions comprising celecoxib and tramadol
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
CA3028450A1 (en) 2016-07-06 2018-01-11 Durect Corporation Oral dosage form with drug composition, barrier layer and drug layer
AU2018332417B2 (en) * 2017-09-15 2023-11-30 Crystalgenomics, Inc. Pharmaceutical composition for treating acute and chronic pain, containing polmacoxib and tramadol
JP7229012B2 (en) * 2018-12-25 2023-02-27 小林製薬株式会社 Pharmaceutical composition for internal use
EP4087559A4 (en) * 2020-01-10 2024-04-17 Briori Biotech, LLC TOPICAL COMPOSITIONS CONTAINING ROFECOXIB AND METHODS FOR THEIR PREPARATION AND USE
WO2022015784A1 (en) 2020-07-15 2022-01-20 Schabar Research Associates Llc Unit oral dose compositions composed of ibuprofen and famotidine for the treatment of acute pain and the reduction of the severity and/or risk of heartburn
CA3124579A1 (en) 2020-07-15 2022-01-15 Schabar Research Associates Llc Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn
US20220133918A1 (en) * 2020-10-07 2022-05-05 Reiley Pharmaceuticals, Inc. Coxib-derived conjugate compounds and methods of use thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US654263A (en) * 1899-12-04 1900-07-24 Edward G Lewis Addressing-machine.
US3800041A (en) 1971-03-02 1974-03-26 Lilly Co Eli Analgesic compositions and methods
US4338324A (en) 1981-03-17 1982-07-06 Mcneilab, Inc. Analgesic potentiation
US4322427A (en) 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
US4489080A (en) 1981-06-26 1984-12-18 The Upjohn Company Process for analgesic treatment
EP0068838B1 (en) 1981-06-26 1986-09-17 The Upjohn Company Analgesic process and composition
US4404210A (en) 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and ibuprofen
US4407804A (en) 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and indomethacin
US4407805A (en) 1982-06-30 1983-10-04 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and zomepirac
US4486436A (en) 1982-07-22 1984-12-04 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4464376A (en) 1982-07-22 1984-08-07 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4567183A (en) * 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4552899A (en) 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4587252A (en) 1984-12-18 1986-05-06 Brighton Pharmaceutical, Inc. Hydrocodone/ibuprofen pharmaceutical compositions and method
US4571400A (en) 1984-12-18 1986-02-18 Belleview Pharmaceutical, Inc. Dihydrocodeine/ibuprofen pharmaceutical compositions and method
CH664085A5 (en) 1985-02-08 1988-02-15 Ciba Geigy Ag PHARMACEUTICAL PREPARATIONS WITH ANALGETIC EFFECTIVENESS AND THEIR PRODUCTION.
US4569937A (en) * 1985-02-11 1986-02-11 E. I. Du Pont De Nemours And Company Analgesic mixture of oxycodone and ibuprofen
GB8521350D0 (en) 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
GB8629567D0 (en) 1986-12-10 1987-01-21 Boots Co Plc Therapeutic agents
US4927854A (en) 1987-12-24 1990-05-22 Analgesic Associates Sustained/enhanced analgesia
DE3822095A1 (en) 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab NEW MEDICAMENT FORMULATION AND METHOD FOR THE PRODUCTION THEREOF
US4855315A (en) * 1988-09-02 1989-08-08 E. R. Squibb & Sons, Inc. Use of zofenopril for the treatment of rheumatoid arthritis
GB8905815D0 (en) 1989-03-14 1989-04-26 Beecham Group Plc Medicament
DE3927113C2 (en) 1989-08-17 1993-11-25 Dolorgiet Gmbh & Co Kg Agent for the treatment of severe pain conditions and process for their preparation
IE66933B1 (en) * 1990-01-15 1996-02-07 Elan Corp Plc Controlled absorption naproxen formulation for once-daily administration
TW225536B (en) 1990-08-23 1994-06-21 Ciba Geigy Ag
US5164398A (en) 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
US5240694A (en) 1991-09-23 1993-08-31 University Of Virginia Combined antiviral and antimediator treatment of common colds
US5516803A (en) 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5472712A (en) * 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5273760A (en) * 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
IT1255522B (en) 1992-09-24 1995-11-09 Ubaldo Conte COMPRESSED FOR THERAPEUTIC USE SUITABLE FOR SELLING ONE OR MORE ACTIVE SUBSTANCES WITH DIFFERENT SPEEDS
US5294195A (en) * 1992-11-02 1994-03-15 Carrier Corporation Cover for the outside enclosure of an air conditioning system
US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
US5376384A (en) * 1992-12-23 1994-12-27 Kinaform Technology, Inc. Delayed, sustained-release pharmaceutical preparation
US5321213A (en) * 1993-01-29 1994-06-14 Conoco Inc. Downhole epicyclic motion orbital seismic source
US5834479A (en) * 1993-03-05 1998-11-10 Mayer; David J. Method and composition for alleviating pain
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
US5436265A (en) 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
GB9319568D0 (en) * 1993-09-22 1993-11-10 Euro Celtique Sa Pharmaceutical compositions and usages
DE69429710T2 (en) 1993-11-23 2002-08-08 Euro-Celtique S.A., Luxemburg/Luxembourg Process for the preparation of a drug composition with delayed drug delivery
CA2182014A1 (en) * 1994-02-01 1995-08-10 Surendra P. Shah Extruded fiber-reinforced cement matrix composites and method of making same
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5552422A (en) 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
EP0809636B1 (en) * 1995-02-13 2002-09-04 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5691374A (en) 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5510368A (en) 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
US5604253A (en) 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5639780A (en) 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
US5785991A (en) 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
US5811126A (en) 1995-10-02 1998-09-22 Euro-Celtique, S.A. Controlled release matrix for pharmaceuticals
ATE334689T1 (en) 1995-11-13 2006-08-15 Univ Northwest ADMINISTRATION MEDIUM FOR ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVE INGREDIENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH MEDIUM AND ACTIVE INGREDIENTS
DE19542281C2 (en) * 1995-11-14 1997-12-04 Boehringer Ingelheim Kg Use of Epinastin for the treatment of migraines
WO1997025988A1 (en) 1996-01-17 1997-07-24 Eli Lilly And Company Methods of treating or preventing pain or nociception
US5789413A (en) 1996-02-01 1998-08-04 Merck Frosst Canada, Inc. Alkylated styrenes as prodrugs to COX-2 inhibitors
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
BR9708574A (en) 1996-04-12 1999-08-03 Searle & Co Benzene sulfonamide derivatives replaced as prodrugs of Cox-2 inhibitors
US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
WO1999007413A1 (en) * 1997-08-11 1999-02-18 Algos Pharmaceutical Corporation Substance p inhibitors in combination with nmda-blockers for treating pain
RS49982B (en) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor
NZ505193A (en) 1997-12-22 2003-03-28 Euro Celtique S Opioid agonist/antagonist combinations
US5881419A (en) * 1997-12-23 1999-03-16 Hose Minder Hose cleaner and holder

Also Published As

Publication number Publication date
US20070191412A1 (en) 2007-08-16
NZ529978A (en) 2005-06-24
US8168629B2 (en) 2012-05-01
ATE462435T1 (en) 2010-04-15
EP1014886A1 (en) 2000-07-05
CY1106044T1 (en) 2011-04-06
EP1014886B1 (en) 2004-11-24
KR20010024032A (en) 2001-03-26
DE69827821T2 (en) 2005-12-08
US8685994B2 (en) 2014-04-01
ES2343322T3 (en) 2010-07-28
US6552031B1 (en) 2003-04-22
ES2235365T3 (en) 2005-07-01
NO20001359L (en) 2000-05-16
EP1518555A1 (en) 2005-03-30
EP1518555B1 (en) 2010-03-31
US20020132825A1 (en) 2002-09-19
HU226116B1 (en) 2008-04-28
HUP0004532A2 (en) 2001-08-28
HU227855B1 (en) 2012-05-02
US20080050427A1 (en) 2008-02-28
AU9398498A (en) 1999-04-05
HUP0004532A3 (en) 2001-12-28
US20020107259A1 (en) 2002-08-08
CZ300531B6 (en) 2009-06-10
HK1030736A1 (en) 2001-05-18
US8188107B2 (en) 2012-05-29
YU16100A (en) 2003-01-31
NO20083175L (en) 2000-05-16
NO325884B1 (en) 2008-08-11
EP1014886A4 (en) 2001-10-17
NO20001359D0 (en) 2000-03-15
NZ503233A (en) 2002-11-26
IL134987A0 (en) 2001-05-20
NO335682B1 (en) 2015-01-19
US20020151559A1 (en) 2002-10-17
CN1278158A (en) 2000-12-27
CZ2000975A3 (en) 2000-09-13
SI1518555T1 (en) 2010-07-30
WO1999013799A1 (en) 1999-03-25
RU2232600C2 (en) 2004-07-20
DE69841590D1 (en) 2010-05-12
US20020099049A1 (en) 2002-07-25
US20020156091A1 (en) 2002-10-24
HU0700296D0 (en) 2007-06-28
RS49982B (en) 2008-09-29
PL191966B1 (en) 2006-07-31
BR9812342A (en) 2000-11-21
DK1518555T3 (en) 2010-07-26
US20020099064A1 (en) 2002-07-25
CA2303309A1 (en) 1999-03-25
KR100444195B1 (en) 2004-08-11
DE69827821D1 (en) 2004-12-30
AU742097B2 (en) 2001-12-20
PT1014886E (en) 2005-03-31
ATE283051T1 (en) 2004-12-15
CA2303309C (en) 2005-07-12
PT1518555E (en) 2010-05-28
US20020143028A1 (en) 2002-10-03
US8193209B2 (en) 2012-06-05
UA72193C2 (en) 2005-02-15
US8143267B2 (en) 2012-03-27
JP2001516699A (en) 2001-10-02
US20120252794A1 (en) 2012-10-04
CY1110160T1 (en) 2015-01-14
CN1241567C (en) 2006-02-15
JP5077903B2 (en) 2012-11-21
TR200001041T2 (en) 2000-08-21

Similar Documents

Publication Publication Date Title
PL339342A1 (en) Synergetically acting analgesic combination of an opioidic antaligic drug and an inhibitor of cyclo-oxygenase-2
ATE320436T1 (en) DIMERIC PYRROLOBENZODIAZEPINES
FR2685869B1 (en) THERAPEUTIC COMPOSITIONS BASED ON MIXED INHIBITORS OF NO SYNTHASE AND CYCLOOXYGENASE.
EA199800367A1 (en) TABLET OF ULTIMATED UREA UREOT
MXPA03002242A (en) Use of rhein for preparing a medicine for preventing articular cartilage damage.
ZA9811346B (en) Substituted heterocyclic benzocycloalkenes and their use as an analgesic
AU9640698A (en) Pharmaceutical combination of a cyclooxigenase-2 inhibitor and acetaminophen or an opiate
DE59811656D1 (en) Kombinationspräparat aus 2-methylthiazolidin-2,4-dicarbonsäure und paracetamol
MXPA04001878A (en) Medicinal compositions containing angiotensin ii receptor antagonist.
PL357906A1 (en) Combination of carboxyalkylethers with antihypertensives and pharmaceutical use
FI20001454A7 (en) System for improving the robocall feature and reminder features of a telephone device
SI1280522T1 (en) Combination of carboxyalkylethers with antihypertensives and pharmaceutical use
IL121990A0 (en) Device for generation and use of multi-layered text
TW450392U (en) Advertisement structure used above the holding ring of the transportation apparatus
AU2001267827A1 (en) Anti-inflammatory and analgesic agents
TW450394U (en) Signboard capable of conveniently replacing and maintaining the lamps

Legal Events

Date Code Title Description
RECP Rectifications of patent specification