PL3237378T3 - Sposób wytwarzania bromku (3RS)-3-[(2SR)-(2-cyklopentylo-2-hydroksy-2-fenyloacetylo)oksy]-1,1-dimetylopirolidynium - Google Patents

Sposób wytwarzania bromku (3RS)-3-[(2SR)-(2-cyklopentylo-2-hydroksy-2-fenyloacetylo)oksy]-1,1-dimetylopirolidynium

Info

Publication number
PL3237378T3
PL3237378T3 PL15808368T PL15808368T PL3237378T3 PL 3237378 T3 PL3237378 T3 PL 3237378T3 PL 15808368 T PL15808368 T PL 15808368T PL 15808368 T PL15808368 T PL 15808368T PL 3237378 T3 PL3237378 T3 PL 3237378T3
Authority
PL
Poland
Prior art keywords
phenylacetyl
cyclopentyl
oxy
hydroxy
preparing
Prior art date
Application number
PL15808368T
Other languages
English (en)
Inventor
Pere Dalmases Barjoan
Joan Huguet Clotet
Mª Ángeles CONDE MARTÍNEZ
Javier Jesús POZA SOTO
Original Assignee
Laboratorios Lesvi, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Lesvi, S.L. filed Critical Laboratorios Lesvi, S.L.
Publication of PL3237378T3 publication Critical patent/PL3237378T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL15808368T 2014-12-24 2015-12-04 Sposób wytwarzania bromku (3RS)-3-[(2SR)-(2-cyklopentylo-2-hydroksy-2-fenyloacetylo)oksy]-1,1-dimetylopirolidynium PL3237378T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382569 2014-12-24
EP15808368.3A EP3237378B1 (en) 2014-12-24 2015-12-04 Process for preparing (3rs)-3-[(2sr)-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide
PCT/EP2015/078668 WO2016102174A1 (en) 2014-12-24 2015-12-04 Process for preparing (3rs)-3-[(2sr)-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide

Publications (1)

Publication Number Publication Date
PL3237378T3 true PL3237378T3 (pl) 2019-06-28

Family

ID=52302106

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15808368T PL3237378T3 (pl) 2014-12-24 2015-12-04 Sposób wytwarzania bromku (3RS)-3-[(2SR)-(2-cyklopentylo-2-hydroksy-2-fenyloacetylo)oksy]-1,1-dimetylopirolidynium

Country Status (6)

Country Link
US (1) US10131630B2 (pl)
EP (1) EP3237378B1 (pl)
JP (1) JP2018501270A (pl)
ES (1) ES2700597T3 (pl)
PL (1) PL3237378T3 (pl)
WO (1) WO2016102174A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3490533T3 (pl) 2016-07-29 2020-11-02 Inke, S.A. Sposób stabilizacji rozmiaru cząstek
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956062A (en) 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
FI49713C (fi) * 1974-05-15 1975-09-10 Medica Pharma Co Ltd Terapeuttisesti tehokkaan erytro-1-metyyli-3-pyrrolidinyyli-alfa-syklo -pentyylimandelaattimetobromidin valmistusmenetelmä.
DK0937041T3 (da) * 1996-11-11 2003-08-11 Christian R Noe Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel
US9926270B2 (en) * 2014-08-20 2018-03-27 Dermira, Inc. Process for production of glycopyrronium tosylate

Also Published As

Publication number Publication date
EP3237378A1 (en) 2017-11-01
ES2700597T3 (es) 2019-02-18
US20170334848A1 (en) 2017-11-23
EP3237378B1 (en) 2018-09-26
US10131630B2 (en) 2018-11-20
WO2016102174A1 (en) 2016-06-30
JP2018501270A (ja) 2018-01-18

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