PL3202772T3 - Kryształ kompleksu inhibitora l-proliny/glukozy sodowej 2 - Google Patents
Kryształ kompleksu inhibitora l-proliny/glukozy sodowej 2Info
- Publication number
- PL3202772T3 PL3202772T3 PL15846001.4T PL15846001T PL3202772T3 PL 3202772 T3 PL3202772 T3 PL 3202772T3 PL 15846001 T PL15846001 T PL 15846001T PL 3202772 T3 PL3202772 T3 PL 3202772T3
- Authority
- PL
- Poland
- Prior art keywords
- proline
- inhibitor
- sodium
- crystal
- complex
- Prior art date
Links
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 title 1
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410523436 | 2014-09-30 | ||
| PCT/CN2015/089128 WO2016050134A1 (zh) | 2014-09-30 | 2015-09-08 | 一种钠-葡萄糖协同转运蛋白2抑制剂的l-脯氨酸复合物、其一水合物及晶体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3202772T3 true PL3202772T3 (pl) | 2021-02-22 |
Family
ID=55629417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15846001.4T PL3202772T3 (pl) | 2014-09-30 | 2015-09-08 | Kryształ kompleksu inhibitora l-proliny/glukozy sodowej 2 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10301344B2 (pl) |
| EP (1) | EP3202772B1 (pl) |
| JP (1) | JP6761564B2 (pl) |
| KR (1) | KR20170060035A (pl) |
| CN (1) | CN105992769B (pl) |
| BR (1) | BR112017005454A2 (pl) |
| CA (1) | CA2961819C (pl) |
| ES (1) | ES2836099T3 (pl) |
| HU (1) | HUE052588T2 (pl) |
| PL (1) | PL3202772T3 (pl) |
| PT (1) | PT3202772T (pl) |
| TW (1) | TWI680983B (pl) |
| WO (1) | WO2016050134A1 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021512910A (ja) * | 2018-02-07 | 2021-05-20 | リアタ ファーマシューティカルズ インコーポレイテッド | ノボビオシン類似体とプロリンとの共結晶形態 |
| CN112375087A (zh) * | 2020-11-27 | 2021-02-19 | 浙江天宇药业股份有限公司 | 一种脯氨酸恒格列净的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011002166A (es) * | 2008-08-28 | 2011-04-07 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,1-triol. |
| ES2544272T3 (es) * | 2010-03-17 | 2015-08-28 | Katholieke Universiteit Leuven | Almacenamiento de productos que respiran |
| CN102372722A (zh) | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
| KR20150048720A (ko) * | 2012-07-11 | 2015-05-07 | 오시리스 쎄라퓨틱스, 인크. | 연골 제품 제조 방법 |
| US9145434B2 (en) * | 2012-07-26 | 2015-09-29 | Boehringer Ingelheim International Gmbh | Crystalline complex of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ss-d-glucopyranos-1-yl)-benzene, methods for its preparation and the use thereof for preparing medicaments |
| EP4245765A3 (en) * | 2013-04-04 | 2024-03-20 | Boehringer Ingelheim Vetmedica GmbH | Treatment of metabolic disorders in equine animals |
| CN104031098A (zh) * | 2014-06-21 | 2014-09-10 | 李友香 | 降糖药物 |
| CN104017031A (zh) | 2014-06-21 | 2014-09-03 | 李友香 | 降血糖药物和组合物 |
-
2015
- 2015-09-08 PL PL15846001.4T patent/PL3202772T3/pl unknown
- 2015-09-08 PT PT158460014T patent/PT3202772T/pt unknown
- 2015-09-08 EP EP15846001.4A patent/EP3202772B1/en active Active
- 2015-09-08 BR BR112017005454A patent/BR112017005454A2/pt not_active IP Right Cessation
- 2015-09-08 US US15/514,118 patent/US10301344B2/en not_active Expired - Fee Related
- 2015-09-08 JP JP2017512686A patent/JP6761564B2/ja not_active Expired - Fee Related
- 2015-09-08 KR KR1020177009290A patent/KR20170060035A/ko not_active Ceased
- 2015-09-08 WO PCT/CN2015/089128 patent/WO2016050134A1/zh not_active Ceased
- 2015-09-08 ES ES15846001T patent/ES2836099T3/es active Active
- 2015-09-08 HU HUE15846001A patent/HUE052588T2/hu unknown
- 2015-09-08 CA CA2961819A patent/CA2961819C/en active Active
- 2015-09-08 CN CN201580008497.4A patent/CN105992769B/zh active Active
- 2015-09-21 TW TW104131089A patent/TWI680983B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2961819A1 (en) | 2016-04-07 |
| TW201612188A (en) | 2016-04-01 |
| EP3202772A4 (en) | 2017-08-09 |
| TWI680983B (zh) | 2020-01-01 |
| BR112017005454A2 (pt) | 2017-12-12 |
| HUE052588T2 (hu) | 2021-05-28 |
| CA2961819C (en) | 2022-11-08 |
| US20170298087A1 (en) | 2017-10-19 |
| WO2016050134A1 (zh) | 2016-04-07 |
| ES2836099T3 (es) | 2021-06-24 |
| PT3202772T (pt) | 2020-11-20 |
| US10301344B2 (en) | 2019-05-28 |
| JP6761564B2 (ja) | 2020-09-30 |
| CN105992769B (zh) | 2019-04-02 |
| EP3202772A1 (en) | 2017-08-09 |
| KR20170060035A (ko) | 2017-05-31 |
| EP3202772B1 (en) | 2020-10-28 |
| CN105992769A (zh) | 2016-10-05 |
| JP2017530107A (ja) | 2017-10-12 |
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