PL3155B1 - Method for the production of stable oily emulsions of bismuth salts. - Google Patents
Method for the production of stable oily emulsions of bismuth salts. Download PDFInfo
- Publication number
- PL3155B1 PL3155B1 PL3155A PL315523A PL3155B1 PL 3155 B1 PL3155 B1 PL 3155B1 PL 3155 A PL3155 A PL 3155A PL 315523 A PL315523 A PL 315523A PL 3155 B1 PL3155 B1 PL 3155B1
- Authority
- PL
- Poland
- Prior art keywords
- bismuth salts
- bismuth
- production
- emulsions
- stable oily
- Prior art date
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- 239000000839 emulsion Substances 0.000 title claims description 11
- 150000001621 bismuth Chemical class 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 18
- 150000002730 mercury Chemical class 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 229910052797 bismuth Inorganic materials 0.000 description 3
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 3
- 150000001622 bismuth compounds Chemical class 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000008168 almond oil Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- -1 fatty acid esters Chemical class 0.000 description 2
- 239000010446 mirabilite Substances 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- 244000242564 Osmanthus fragrans Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
Description
W ostatnich czasach zwiazki bizmutowe nabraly wielkiego znaczenia w lecznictwie.Dla korzystnego stosowania ich potrzebne sa przetwory, zawierajace zwiazki te w stanie rozpuszczonym lub najdrobniej zmie¬ szanym i nadajace sie do stosowania do¬ zylnie i woigóle pozajelitowo. Dla wstrzy- kiwan podskórnych i domiesniowych emul¬ sje nierozpuszczalnych zwiazków bizmuto¬ wych okazaly sie szczególnie korzystne.Stwierdzono, ze mozna otrzymac trwa¬ le, oleiste emulsje soli bizmutowych przez rozpuszczenie soli bizmutowych kwasów tluszczowych w odpowiednich organicz¬ nych srodkach rozpuszczajacych, a dalej przez zmieszanie tych rozczynów z olejem i wreszcie oddestylowanie organicznego srodka rozpuszczajacego. W ten sposób otrzymane emulsje nie wydzielaija zadnych osadów nawet po dluzszem staniu. Zwiazki bizmutowe sa z olejem stale najdokladniej zmieszane, wobec czego emulsje te daja sie z latwoscia wstrzykiwac i dobrze wchlaniac.Do wytwarzaniia emulsyj nadaja sie szczególnie sole bizmutowe wyzszych kwa¬ sów tluszczowych. Jafko srodki emulguja¬ ce, mozna stosowac naturalne oleje, jak równiez syntetyczne estry kwasów tlu¬ szczowych i oleje mineralne.W patencie niemieckim Nr 346507 opi¬ sano wytwarzatnie rozczynów soli rtecio- wych w olejach i tluszczach, polegajace na tern, ze sole zostaja rozpuszczone w lotnym srodku rozpuszczajacym, rozczyn zostaje zmiibszany z tluszczem, i wreszcie lotny sro¬ dek rozpuszczajacy zostaje usuniety*Od spoeofaa Mniejszego rózni sie opi¬ sany w patencie niemieckim sposób naj¬ przód tern, ze odnosi sie do soli rteciowych.Nastepnie ma on na celu otrzymywanie rozczynów soli rteciowych w olejach i tlu¬ szczach, podczas gdy w sposobie niniej¬ szym celem ostatecznym jest wytwarzanie trwalych emailsyj. Ze sposobu wedlug pa¬ tentu Nr 246507, czyli z zachowania1 sie soli rteciowych, rozpuszczajacych sie w o- lejach i tluszczach, nie naissiwala sie mysl, ze sole bizmutowe daja trwale emulsje.^ Przyklad; I. 1 czesc wagowa okimami fózmutoii|e|^y^pU9Zcza sie w 10—15 cze- sciacli wagowych eteru. Rozczyn* osuszo¬ ny wyzarzona sola glauberska i przesaczo¬ ny^ miesza sie z 4 czesciami oleju oliwnego i oddestylowuje eter najprzód przy cisnie¬ niu zfwyklem, a nastepnie w prózni. Za^ miiaist oleju oliwnego moznai zastosowac takze olej migdalowy lub parafinowy. 0- trzymuje s&e btate, dosc ciezko plynne, trwale emulsje z zawartoscia 4% bizmutu.Przyklad II. 1 czesc soli bizmutowej dwu.jodku kwasu taririnowego rozpuszcza sie w 5 czesciach eteru. Zamiast 5 czesci eteru mozna wziac takze 10—15 czesci) ben- zolu lub 10 czesci eteru naftowego. Roz- czyn, wysuszony wyzarzona sola glauber- ska i przesaczony, miesza sie z 4 czesciami oleju oliwnego i oddestylowtije eter, wzglednie benzol lub eter naftowy, naj¬ przód przy cisnieniu zwyklem, a nastepnie w prózni'. Otrzymuje sie jasnozólte, dez- koplynne, trwlale emulsje z zawartoscia o- kolo 2% bizmutu.Przyklad III. 1 czesc soli bizmutowej kwasu linolowego rozpuszcza sie w 15 cze¬ sciach eteru. Wysuszony i przesaczony rozczyn miesza sie z 4 czesciami oleju mig¬ dalowego i oddestylowane eter najprzód przy cisnieniu zwyklem, a nastepnie w prózni. Otrzymuje sie jaisnoizólte, ciezko- plynne trwale emulsje z zawartoscia okolo 4% bizmutu. PLIn recent times, bismuth compounds have gained great importance in medicine. For their beneficial use, preparations are needed that contain these compounds in a dissolved or finely mixed state, and can be used intravenously and parenterally. For subcutaneous and intramuscular injections, emulsions of insoluble bismuth compounds have proved to be particularly advantageous. It has been found that stable, oily emulsions of bismuth salts can be obtained by dissolving bismuth salts of fatty acids in suitable organic dissolving agents, followed by mixing these solutions with oil and finally distilling off the organic dissolving agent. The emulsions thus obtained do not release any deposits even after prolonged standing. The bismuth compounds are constantly mixed with the oil most thoroughly, so that these emulsions can be easily injected and well absorbed. The bismuth salts of the higher fatty acids are especially suitable for the preparation of emulsions. As an emulsifying agent, natural oils can be used, as well as synthetic fatty acid esters and mineral oils. German Patent No. 346507 describes the production of mercury salt solutions in oils and fats in which the salts are dissolved. in a volatile dissolving agent, the liquor is mixed with fat, and finally the volatile dissolving sore is removed * From the backwash of Minor, the first difference described in the German patent is that it refers to mercury salts. the preparation of solutions of mercury salts in oils and fat, whereas in the present process the ultimate goal is the preparation of permanent emails. From the method according to the patent No. 246507, that is, the preservation of mercury salts, dissolving in oils and fats, it was not ignored that bismuth salts give stable emulsions. I. 1 part by weight okimami fózmutoii | e | ^ y ^ pU9 is combined in 10-15 parts by weight of ether. The dilution, the dried, annealed Glauber's salt and the filtered one, is mixed with 4 parts of olive oil and the ether is distilled first by usual pressure and then under vacuum. For the sweet olive oil, you can also use almond or paraffin oil. 0- holds s & e btates, quite liquid, stable emulsions with 4% bismuth. Example II. 1 part of the bismuth salt of tartirinic acid di-iodide is dissolved in 5 parts of ether. Instead of 5 parts of ether, you can also take 10-15 parts of petrol or 10 parts of petroleum ether. The leaven, dried, annealed Glauber salt and filtered, is mixed with 4 parts of olive oil and distilled ether, or benzol or petroleum ether, first under ordinary pressure and then under vacuum. A light yellow, dc-liquid, stable emulsion with a bismuth content of about 2% is obtained. Example III. 1 part of linoleic acid bismuth salt is dissolved in 15 parts of ether. The dried and filtered solution is mixed with 4 parts of almond oil and the ether distilled first under normal pressure and then under vacuum. Light yellow, heavy-liquid, stable emulsions with a bismuth content of about 4% are obtained. PL
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Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3155B1 true PL3155B1 (en) | 1925-11-30 |
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