PL3105313T3 - Moduł molekularnego zaworu upustowego dla biochemii syntetycznej który utrzymuje równowagę kofaktorów - Google Patents

Moduł molekularnego zaworu upustowego dla biochemii syntetycznej który utrzymuje równowagę kofaktorów

Info

Publication number
PL3105313T3
PL3105313T3 PL15774454T PL15774454T PL3105313T3 PL 3105313 T3 PL3105313 T3 PL 3105313T3 PL 15774454 T PL15774454 T PL 15774454T PL 15774454 T PL15774454 T PL 15774454T PL 3105313 T3 PL3105313 T3 PL 3105313T3
Authority
PL
Poland
Prior art keywords
maintains
purge valve
valve module
factor balance
synthetic biochemistry
Prior art date
Application number
PL15774454T
Other languages
English (en)
Inventor
James U. Bowie
Paul H. Opgenorth
Tyler P. Korman
Original Assignee
The Regents Of The University Of California Office Of Technology Transfer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California Office Of Technology Transfer filed Critical The Regents Of The University Of California Office Of Technology Transfer
Publication of PL3105313T3 publication Critical patent/PL3105313T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01051—Pyruvate dehydrogenase (NADP+) (1.2.1.51)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/99—Oxidoreductases acting on NADH or NADPH (1.6) with other acceptors (1.6.99)
    • C12Y106/99001—NADPH dehydrogenase (1.6.99.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
    • C12Y108/01004—Dihydrolipoyl dehydrogenase (1.8.1.4), i.e. lipoamide-dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01012—Dihydrolipoyllysine-residue acetyltransferase (2.3.1.12)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL15774454T 2014-04-02 2015-04-02 Moduł molekularnego zaworu upustowego dla biochemii syntetycznej który utrzymuje równowagę kofaktorów PL3105313T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461974311P 2014-04-02 2014-04-02
PCT/US2015/024181 WO2015153929A2 (en) 2014-04-02 2015-04-02 A synthetic biochemistry molecular purge valve module that maintain co-factor balance
EP15774454.1A EP3105313B1 (en) 2014-04-02 2015-04-02 A synthetic biochemistry molecular purge valve module that maintains co-factor balance

Publications (1)

Publication Number Publication Date
PL3105313T3 true PL3105313T3 (pl) 2020-06-29

Family

ID=54241447

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15774454T PL3105313T3 (pl) 2014-04-02 2015-04-02 Moduł molekularnego zaworu upustowego dla biochemii syntetycznej który utrzymuje równowagę kofaktorów

Country Status (5)

Country Link
US (2) US10196653B2 (pl)
EP (2) EP3636743A1 (pl)
ES (1) ES2786226T3 (pl)
PL (1) PL3105313T3 (pl)
WO (1) WO2015153929A2 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3636743A1 (en) * 2014-04-02 2020-04-15 The Regents of The University of California A synthetic biochemistry molecular purge valve module that maintains co-factor balance
ES2937642T3 (es) * 2014-06-11 2023-03-30 Univ Duke Composiciones y métodos para el control de flujo rápido y dinámico usando válvulas metabólicas sintéticas
US11104919B2 (en) 2015-07-21 2021-08-31 The Regents Of The University Of California Cell-free metabolic pathway for glucose metabolism with a molecular purge valve
EP3529365A4 (en) * 2016-10-18 2020-07-15 The Regents of the University of California MOLECULAR RHEOSTAT FOR COFACTOR BALANCE
EP4347800A1 (en) 2021-05-26 2024-04-10 Invizyne Technologies, Inc. Prenyltransferase variants with increased thermostability

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6015891A (en) 1988-09-09 2000-01-18 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene having a modified frequency of codon usage
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
TW201343623A (zh) * 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
US9657316B2 (en) * 2012-08-27 2017-05-23 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
EP3636743A1 (en) * 2014-04-02 2020-04-15 The Regents of The University of California A synthetic biochemistry molecular purge valve module that maintains co-factor balance

Also Published As

Publication number Publication date
WO2015153929A2 (en) 2015-10-08
WO2015153929A3 (en) 2015-11-26
ES2786226T3 (es) 2020-10-09
EP3105313B1 (en) 2020-01-29
US10196653B2 (en) 2019-02-05
EP3105313A4 (en) 2017-08-16
US20170183688A1 (en) 2017-06-29
EP3636743A1 (en) 2020-04-15
EP3105313A2 (en) 2016-12-21
US10822623B2 (en) 2020-11-03
US20190271010A1 (en) 2019-09-05

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