PL3082805T3 - Podstawione amino-triazole i sposoby z ich użyciem - Google Patents

Podstawione amino-triazole i sposoby z ich użyciem

Info

Publication number
PL3082805T3
PL3082805T3 PL14871777T PL14871777T PL3082805T3 PL 3082805 T3 PL3082805 T3 PL 3082805T3 PL 14871777 T PL14871777 T PL 14871777T PL 14871777 T PL14871777 T PL 14871777T PL 3082805 T3 PL3082805 T3 PL 3082805T3
Authority
PL
Poland
Prior art keywords
methods
same
substituted amino
amino triazoles
triazoles
Prior art date
Application number
PL14871777T
Other languages
English (en)
Inventor
Michael L. CORMAN
William M. HUNGERFORD
Adam Golebiowski
Raymond P. Beckett
Marzena MAZUR
Sylwia OLEJNICZAK
Jacek OLCZAK
Original Assignee
Institute For Drug Discovery, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Discovery, Llc filed Critical Institute For Drug Discovery, Llc
Publication of PL3082805T3 publication Critical patent/PL3082805T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
PL14871777T 2013-12-20 2014-12-19 Podstawione amino-triazole i sposoby z ich użyciem PL3082805T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919117P 2013-12-20 2013-12-20
EP14871777.0A EP3082805B1 (en) 2013-12-20 2014-12-19 Substituted amino triazoles, and methods using same
PCT/US2014/071490 WO2015095701A1 (en) 2013-12-20 2014-12-19 Substituted amino triazoles, and methods using same

Publications (1)

Publication Number Publication Date
PL3082805T3 true PL3082805T3 (pl) 2020-09-21

Family

ID=53403739

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14871777T PL3082805T3 (pl) 2013-12-20 2014-12-19 Podstawione amino-triazole i sposoby z ich użyciem

Country Status (9)

Country Link
US (1) US10214531B2 (pl)
EP (1) EP3082805B1 (pl)
JP (1) JP2017501226A (pl)
CN (1) CN106659715A (pl)
AU (1) AU2014369053B2 (pl)
CA (1) CA2937147A1 (pl)
PL (1) PL3082805T3 (pl)
SG (1) SG11201605757SA (pl)
WO (1) WO2015095701A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106659697B (zh) * 2014-05-30 2022-03-29 斯菲叶尔制药私有公司 作为抗结核剂的化合物
PL415073A1 (pl) * 2014-12-19 2016-06-20 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
WO2017021920A1 (en) * 2015-08-05 2017-02-09 Indivior Uk Limited Dopamine d3 receptor antagonists having a bicyclo moiety
PL415078A1 (pl) 2015-09-04 2017-03-13 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
KR20200043409A (ko) 2017-08-21 2020-04-27 아카디아 파마슈티칼스 인코포레이티드 질병 치료를 위한 화합물, 이의 염 및 방법
US11440884B2 (en) * 2017-08-21 2022-09-13 Acadia Pharmaceuticals Inc. Compounds, salts thereof and methods for treatment of diseases
IL277071B1 (en) 2018-03-08 2024-03-01 Incyte Corp Aminopyrizine diol compounds as PI3K–y inhibitors
CN108467395B (zh) * 2018-05-09 2020-12-11 大连理工大学 一种几丁质酶抑制剂及其应用
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
BR112022000325A2 (pt) 2019-07-11 2022-03-15 Escape Bio Inc Indazois e azaindazois como inibidores de lrrk2
CN114466845A (zh) * 2019-09-25 2022-05-10 昂科艾伦迪治疗法公司 制备5-(4-((2s,5s)-5-(4-氯苄基)-2-甲基吗啉代)哌啶-1-基)-1h-1,2,4-三唑-3-胺的方法
US20230125481A1 (en) * 2020-01-28 2023-04-27 Evotec International Gmbh Modulators of the integrated stress response pathway
CN111732571B (zh) * 2020-07-24 2021-06-29 广西壮族自治区农业科学院 一种用于防治香蕉枯萎病的杀植物真菌剂
CN114835687B (zh) * 2021-04-02 2023-09-05 北京华森英诺生物科技有限公司 AhR抑制剂
AU2022292554A1 (en) 2021-06-14 2024-01-04 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer
US20230348516A1 (en) * 2022-04-29 2023-11-02 Molecure S.A. Ykl-40 inhibitors and their therapeutic applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4421753A (en) * 1982-01-15 1983-12-20 American Cyanamid Company 1-(5-Amino-4H-1,2,4-triazol-3-yl)-4-substituted-piperazines
US4582833A (en) * 1984-04-16 1986-04-15 American Cyanamid Company 2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines
GB0325745D0 (en) * 2003-11-05 2003-12-10 Astrazeneca Ab Chemical compounds
US8183241B2 (en) 2005-06-01 2012-05-22 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives
WO2009082526A2 (en) 2007-10-05 2009-07-02 Pharmacopeia, Inc. Ortho pyrrolidine, benzyl-substituted heterocycle ccr1 antagonists for autoimmune diseases & inflammation
KR20140047032A (ko) 2011-03-24 2014-04-21 얀센 파마슈티칼즈, 인코포레이티드 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체

Also Published As

Publication number Publication date
EP3082805A1 (en) 2016-10-26
WO2015095701A1 (en) 2015-06-25
AU2014369053B2 (en) 2019-03-14
SG11201605757SA (en) 2016-08-30
JP2017501226A (ja) 2017-01-12
CN106659715A (zh) 2017-05-10
AU2014369053A1 (en) 2016-07-28
US20160297823A1 (en) 2016-10-13
EP3082805B1 (en) 2020-02-05
US10214531B2 (en) 2019-02-26
EP3082805A4 (en) 2017-05-10
CA2937147A1 (en) 2015-06-25

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