PL29626B1 - , vaginal pills, sticks, etc., resistant to tropical temperatures. - Google Patents
, vaginal pills, sticks, etc., resistant to tropical temperatures. Download PDFInfo
- Publication number
- PL29626B1 PL29626B1 PL29626A PL2962638A PL29626B1 PL 29626 B1 PL29626 B1 PL 29626B1 PL 29626 A PL29626 A PL 29626A PL 2962638 A PL2962638 A PL 2962638A PL 29626 B1 PL29626 B1 PL 29626B1
- Authority
- PL
- Poland
- Prior art keywords
- sticks
- suppositories
- sugar
- vaginal
- resistant
- Prior art date
Links
- 239000006187 pill Substances 0.000 title claims description 4
- 239000000829 suppository Substances 0.000 claims description 13
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000001543 Corylus americana Nutrition 0.000 claims 1
- 240000007582 Corylus avellana Species 0.000 claims 1
- 235000007466 Corylus avellana Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229940110456 cocoa butter Drugs 0.000 description 4
- 235000019868 cocoa butter Nutrition 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229960005195 morphine hydrochloride Drugs 0.000 description 1
- XELXKCKNPPSFNN-BJWPBXOKSA-N morphine hydrochloride trihydrate Chemical compound O.O.O.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O XELXKCKNPPSFNN-BJWPBXOKSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Description
Do wyrobu czopków, pigulek pochwo¬ wych, paleczek itd. stosuje sie zwykle ma¬ slo kakaowe albo inne tluszcze, tajtze lacz¬ nie z woskiem, parafina lub podobnymi srodkami wiazacymi, przy czym sklad mieszaniny musi byc dobrany tak, aby jej punkt topliwosci lezal ponizej temperatury ciala ludzkiego. Czopki zawierajace takie srodki sa trwale tylko w (pewnych warun¬ kach. W wyzszych temperaturach, np. tro¬ pikalnych, miekna i topia sie, przez co tra¬ ca ksztalt i staja sie bezuzyteczne.Proponowano juz otrzymywanie czop¬ ków odpornych w temperaturach tropikal¬ nych przy pomocy mydla, gliceryny z ze¬ latyna, amin lub amidów albo srodków po¬ dobnych. Lecz równiez tego rodzaju czop¬ ki staja sie bezuzyteczne, poniewaz srodki tworzace zel traca przy przechowywaniu wode, przy czym czopki ulegaja znieksztal¬ ceniu, a ponadto gliceryna lub mydlo od¬ dzialywaja w takich dawkach drazniaco na blony sluzowe wywolujac np. przeczyszcze¬ nie. Równiez proponowano wytwarzac czopki o podstawowej masie nosnej, skla¬ dajacej sie z 70 — 75 czesci mocznika, 20 — 25 czesci cukru i ewentualnie masla kakaowego lub innych dodatków. Tego ro¬ dzaju masy nie sa co prawda szkodliwe pod wzgledem zdrowotnym, jednakze dzialaja fizjologicznie w taki sposób, iz powoduja silne przeczyszczenie, wskutek czego lek zawarty w czopku zostaje calkowicie lub czesciowo usuniety.Obecnie stwierdzono, iz mozna wytwa¬ rzac czopki, pigulki pochwowe, paleczki itd., trwale w temperaturach tropiikal- nych i ponad to nie wykazujace dziala- ubocznych, stosujac jako material nosny stale, rozpuszczalne w wodzie ii fizjologicz¬ nie obojetne weglowodany, np. cukier trzcinowy, gronowy lub mlekowy. Powyz¬ sze weglowodany miesza sie w zwyklej temperaturze ze srodkiem leczniczym, naj¬ lepiej w postaci mialko ^proszkowanej mieszaniny, granuluje ze stopionym tlusz^ czem, a otrzymywane granulki, skladajace sie glównie, np. w 80°/e^ach, z weglowo¬ danów, prasuje na czopki. Przeróbke gra¬ nulowanej .masy mozna uskuteczniac w urzadzeniach podobnych do urzadzen slu¬ zacych do wyrobu drazetek; jest to rów¬ niez duza zaleta takiej przeróbki mas nie- plasitycznych, gdyz przewaznie stosowane dotychczas masy plastyczne mogly byc przerabiane na zadane ksztaltki jedynie przez odlewanie lub prasowanie.Czopki, otrzymane sposobem wedlug wynalazku niniejszego, sa nietopliwe na¬ wet przy dluzszym przechowywaniu w temperaturze tropikalnej, np. w tempera¬ turach 50 — 70°C. Srodek leczniczy oraz weglowodany rozpuszczajiie w wodzie zo¬ staja wchloniete przez blone sluzowa nie powodujac dzialan ubocznych.Przyklad L 209 czesci cukru grono¬ wego miele sie dokladnie z 1 czescia chlo¬ rowodorku morfiny i nastepnie granuluje z 40 czesciami stopionego masla kakaowe¬ go. Z masy granulowanej prasuje sie 100 czopków o wadze 2,5 g.Przyklad II. 205 czesci cukru mleko¬ wego lub trzcinowego miele sie dokladnie z 5 czesciami extractum belladonnae i gra¬ nuluje z 40 czesciajmi stopionego masla ka¬ kaowego. Z masy granulowanej otrzymu¬ je sie 100 czopków o wadze 2,5 g. PLCocoa butter or other fats, including wax, paraffin or similar binders, are usually used for the preparation of suppositories, vaginal pills, sticks, etc., and the composition of the mixture must be such that its melting point lies below the temperature of the human body. Suppositories containing such agents are only stable under certain conditions. At higher temperatures, for example triplets, they soften and melt, thereby loosing their shape and rendering them unusable. It has already been proposed to obtain suppositories that are resistant to tropical temperatures. These suppositories are rendered useless as well, because the gel-forming agents lose water in storage, and the suppositories become deformed and in addition, glycerin or soap, in such doses, irritate the mucous membranes, causing, for example, laxation. It has also been proposed to produce suppositories with a basic weight, consisting of 70-75 parts of urea, 20-25 parts of sugar and possibly cocoa butter. Although these kinds of masses are not harmful to health, they have a physiological effect in such a way that they cause severe purgation, as a result of which the drug contains The vaginal suppository is completely or partially removed. It has now been found that it is possible to prepare suppositories, vaginal pills, sticks, etc., stable at tropical temperatures and, moreover, showing no side effects, using a constant water-soluble material as the carrier material. physiologically neutral carbohydrates, for example, cane, grape or milk sugar. The above-mentioned carbohydrates are mixed at the usual temperature with a medicament, preferably in the form of a fine, powdered mixture, granulated with the molten fat, and the resulting granules, consisting mainly of, for example, 80% of carbon, ¬ danów, pressed into suppositories. The processing of granulated mass can be effected in equipment similar to those for the production of pellets; This is also a great advantage of such a processing of non-plastic masses, because usually the plastic masses used so far could only be processed into desired shapes by casting or pressing. The suppositories obtained by the method of the present invention are infusible even after prolonged storage at temperature tropical, for example at temperatures of 50-70 ° C. The medicament and the water-soluble carbohydrates are absorbed by the mucosa without causing side effects. Example L 209 parts of grilled sugar are ground exactly with 1 part of morphine hydrochloride and then granulated with 40 parts of melted cocoa butter. 100 suppositories weighing 2.5 g are pressed from the granulated mass. Example II. 205 parts of milk or cane sugar are ground to exactly 5 parts of extractum belladonnae and granulated with 40 parts of melted cocoa butter. From the granulated mass, 100 suppositories weighing 2.5 g are obtained
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL29626B1 true PL29626B1 (en) | 1941-03-31 |
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