PL2917229T3 - Przeciwciała i ich fragmenty aktywowane przeciwko domenie alfa-3 białka HLA-G, sposoby i środki ich wytwarzania oraz ich zastosowania - Google Patents
Przeciwciała i ich fragmenty aktywowane przeciwko domenie alfa-3 białka HLA-G, sposoby i środki ich wytwarzania oraz ich zastosowaniaInfo
- Publication number
- PL2917229T3 PL2917229T3 PL13791794T PL13791794T PL2917229T3 PL 2917229 T3 PL2917229 T3 PL 2917229T3 PL 13791794 T PL13791794 T PL 13791794T PL 13791794 T PL13791794 T PL 13791794T PL 2917229 T3 PL2917229 T3 PL 2917229T3
- Authority
- PL
- Poland
- Prior art keywords
- hla
- antibodies
- fragments
- alpha
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12306398.4A EP2730588A1 (en) | 2012-11-12 | 2012-11-12 | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
EP13791794.4A EP2917229B1 (en) | 2012-11-12 | 2013-11-12 | Antibodies and fragments thereof raised against the alpha-3 domain of hla-g protein, methods and means for their preparation, and uses thereof |
PCT/EP2013/073648 WO2014072534A1 (en) | 2012-11-12 | 2013-11-12 | Antibodies and fragments thereof raised against the alpha-3 domain of hla-g protein, methods and means for their preparation, and uses thereof. |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2917229T3 true PL2917229T3 (pl) | 2021-01-11 |
Family
ID=47221996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL13791794T PL2917229T3 (pl) | 2012-11-12 | 2013-11-12 | Przeciwciała i ich fragmenty aktywowane przeciwko domenie alfa-3 białka HLA-G, sposoby i środki ich wytwarzania oraz ich zastosowania |
Country Status (7)
Country | Link |
---|---|
US (1) | US10005845B2 (pl) |
EP (2) | EP2730588A1 (pl) |
CA (1) | CA2891184A1 (pl) |
DK (1) | DK2917229T3 (pl) |
ES (1) | ES2786049T3 (pl) |
PL (1) | PL2917229T3 (pl) |
WO (1) | WO2014072534A1 (pl) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2730588A1 (en) | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
CN107533051B (zh) * | 2015-03-27 | 2020-11-13 | 南加利福尼亚大学 | Hla-g作为car t细胞免疫疗法的新靶标 |
JP2018518152A (ja) | 2015-03-27 | 2018-07-12 | ユニバーシティ オブ サザン カリフォルニア | 充実性腫瘍を処置するためのlhrに指向されたcar t細胞治療 |
CN109563169B (zh) * | 2016-06-03 | 2022-07-01 | 英韦克泰斯公司 | 抗hla-g特异性抗体 |
AU2017301705A1 (en) * | 2016-07-26 | 2019-01-24 | North Carolina State University | Vector-mediated immune tolerance in the eye |
TW201829463A (zh) * | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
ES2916217T3 (es) | 2017-01-05 | 2022-06-29 | Kahr Medical Ltd | Una proteína de fusión SIRP1 ALPHA-41BBL y métodos de uso de la misma |
WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
HRP20230937T1 (hr) | 2017-01-05 | 2023-11-24 | Kahr Medical Ltd. | Pd1-41bbl fuzijski protein i metode korištenja istog |
TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗-ilt4抗體及抗原結合片段 |
CA3063959A1 (en) * | 2017-05-23 | 2018-11-29 | Valentin BRUTTEL | Combinations of mhc class ib molecules and peptides for targeted therapeutic immunomodulation |
EP3434688A1 (en) * | 2017-07-24 | 2019-01-30 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Hla-g transcripts and isoforms and their uses |
WO2019177054A1 (ja) * | 2018-03-13 | 2019-09-19 | 国立大学法人北海道大学 | 腫瘍予防又は治療剤、pd-l1抑制剤、腫瘍予防又は治療剤のスクリーニング方法及びpd-l1抑制剤のスクリーニング方法 |
AR114789A1 (es) * | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
US11492387B2 (en) * | 2018-05-09 | 2022-11-08 | Tianjin Dongya Biological Technology Co., Ltd. | Broad spectrum vaccine, preparing method and application thereof |
CN113056483A (zh) | 2018-07-09 | 2021-06-29 | 戊瑞治疗有限公司 | 结合到ilt4的抗体 |
MA53381A (fr) | 2018-07-24 | 2021-06-02 | Amgen Inc | Association d'inhibiteurs de la voie lilrb1/2 et d'inhibiteurs de la voie pd-1 |
WO2020043899A1 (en) * | 2018-08-31 | 2020-03-05 | Invectys | Chimeric antigen receptors against multiple hla-g isoforms |
WO2020069133A1 (en) | 2018-09-27 | 2020-04-02 | Tizona Therapeutics | Anti-hla-g antibodies, compositions comprising anti-hla-g antibodies and methods of using anti-hla-g antibodies |
CN113045656B (zh) * | 2020-07-27 | 2022-03-08 | 台州恩泽医疗中心(集团) | 抗hla-g异构体分子hla-g5及hla-g6的单克隆抗体及其用途 |
US20220306747A1 (en) * | 2021-03-24 | 2022-09-29 | China Medical University Hospital | Anti-tumor antigen nanobody and nucleic acid encoding sequence thereof, and uses of the same |
US11795227B2 (en) * | 2021-03-24 | 2023-10-24 | Shine-On Biomedical Co., Ltd. | Immunomodulation and anti-tumor-related nanobody and nucleic acid encoding sequence thereof, and uses of the same |
GB202111905D0 (en) * | 2021-08-19 | 2021-10-06 | UCB Biopharma SRL | Antibodies |
WO2023184734A1 (zh) * | 2022-03-31 | 2023-10-05 | 台州恩泽医疗中心(集团) | 一种抗hla-g1,-g2,-g5及hla-g6异构体分子的单克隆抗体及其用途 |
CN115819583A (zh) * | 2022-03-31 | 2023-03-21 | 台州恩泽医疗中心(集团) | 一种抗hla-g分子的单克隆抗体及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999042128A1 (fr) * | 1998-02-20 | 1999-08-26 | Commissariat A L'energie Atomique | Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications |
EP1328290A2 (en) | 2000-09-15 | 2003-07-23 | University of Kansas Medical Center | Expression, preparation, uses, and sequence of recombinantly-derived soluble hla-g |
FR2856599A1 (fr) | 2003-06-30 | 2004-12-31 | Commissariat Energie Atomique | Utilisation de compositions contenant une forme soluble d'hla-g dans le traitement de pathologies du sang. |
US9175064B2 (en) | 2003-11-04 | 2015-11-03 | Shuji Miyagawa | HLA-E chimeric molecule |
CN1312182C (zh) | 2004-10-26 | 2007-04-25 | 四川新创生物科技有限公司 | 抗hla-g的单克隆抗体及分泌它的杂交瘤细胞株、癌症诊断试剂盒及其应用 |
WO2009100135A2 (en) * | 2008-02-04 | 2009-08-13 | Medical College Georgia Research Institute, Inc. | Hla-g compositions and methods of use thereof |
RU2605318C2 (ru) * | 2009-05-05 | 2016-12-20 | Новиммун С.А. | Анти-il-17f антитела и способы их применения |
CA2764860C (en) | 2009-06-25 | 2018-04-24 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Multimeric polypeptides of hla-g including at least two alpha3 domains and pharmaceutical uses thereof |
CN101967191A (zh) | 2009-07-28 | 2011-02-09 | 广州天美生物技术有限公司 | Hla-g抗体制备方法及其在医学中的应用 |
US20130177574A1 (en) | 2012-01-11 | 2013-07-11 | Paul I. Terasaki Foundation Laboratory | ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE |
EP2730588A1 (en) | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
CN109563169B (zh) | 2016-06-03 | 2022-07-01 | 英韦克泰斯公司 | 抗hla-g特异性抗体 |
-
2012
- 2012-11-12 EP EP12306398.4A patent/EP2730588A1/en not_active Withdrawn
-
2013
- 2013-11-12 WO PCT/EP2013/073648 patent/WO2014072534A1/en active Application Filing
- 2013-11-12 ES ES13791794T patent/ES2786049T3/es active Active
- 2013-11-12 EP EP13791794.4A patent/EP2917229B1/en not_active Revoked
- 2013-11-12 PL PL13791794T patent/PL2917229T3/pl unknown
- 2013-11-12 CA CA2891184A patent/CA2891184A1/en active Pending
- 2013-11-12 US US14/442,320 patent/US10005845B2/en active Active
- 2013-11-12 DK DK13791794.4T patent/DK2917229T3/da active
Also Published As
Publication number | Publication date |
---|---|
US10005845B2 (en) | 2018-06-26 |
CA2891184A1 (en) | 2014-05-15 |
EP2917229A1 (en) | 2015-09-16 |
EP2730588A1 (en) | 2014-05-14 |
ES2786049T3 (es) | 2020-10-08 |
US20160272724A1 (en) | 2016-09-22 |
DK2917229T3 (da) | 2020-04-06 |
WO2014072534A1 (en) | 2014-05-15 |
EP2917229B1 (en) | 2020-01-08 |
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