PL2855434T3 - Formy ciała stałego n-((s)-2,3-dihydroksy-propylo)-3-(2-fluoro-4- jodo-fenyloaminohzonikotynoawidu - Google Patents

Formy ciała stałego n-((s)-2,3-dihydroksy-propylo)-3-(2-fluoro-4- jodo-fenyloaminohzonikotynoawidu

Info

Publication number
PL2855434T3
PL2855434T3 PL13725913.1T PL13725913T PL2855434T3 PL 2855434 T3 PL2855434 T3 PL 2855434T3 PL 13725913 T PL13725913 T PL 13725913T PL 2855434 T3 PL2855434 T3 PL 2855434T3
Authority
PL
Poland
Prior art keywords
isonicotinamide
phenylamino
iodo
dihydroxy
fluoro
Prior art date
Application number
PL13725913.1T
Other languages
English (en)
Inventor
Axel Becker
Christoph Saal
Clemens Kuehn
Donald Bankston
Marco Poma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2855434T3 publication Critical patent/PL2855434T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
PL13725913.1T 2012-05-30 2013-05-07 Formy ciała stałego n-((s)-2,3-dihydroksy-propylo)-3-(2-fluoro-4- jodo-fenyloaminohzonikotynoawidu PL2855434T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261653037P 2012-05-30 2012-05-30

Publications (1)

Publication Number Publication Date
PL2855434T3 true PL2855434T3 (pl) 2016-12-30

Family

ID=48537929

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13725913.1T PL2855434T3 (pl) 2012-05-30 2013-05-07 Formy ciała stałego n-((s)-2,3-dihydroksy-propylo)-3-(2-fluoro-4- jodo-fenyloaminohzonikotynoawidu

Country Status (30)

Country Link
US (1) US9260393B2 (pl)
EP (1) EP2855434B1 (pl)
JP (1) JP6280543B2 (pl)
KR (1) KR20150022923A (pl)
CN (1) CN104334530A (pl)
AR (1) AR091186A1 (pl)
AU (1) AU2013269994B2 (pl)
BR (1) BR112014029838A2 (pl)
CA (1) CA2875145C (pl)
CL (1) CL2014003285A1 (pl)
DK (1) DK2855434T3 (pl)
EA (1) EA028059B1 (pl)
ES (1) ES2592860T3 (pl)
HK (1) HK1206733A1 (pl)
HR (1) HRP20161135T1 (pl)
HU (1) HUE028850T2 (pl)
IL (1) IL235947A (pl)
LT (1) LT2855434T (pl)
MX (1) MX350295B (pl)
MY (1) MY169266A (pl)
NZ (1) NZ701103A (pl)
PL (1) PL2855434T3 (pl)
PT (1) PT2855434T (pl)
RS (1) RS55167B1 (pl)
SG (1) SG11201407842TA (pl)
SI (1) SI2855434T1 (pl)
TW (1) TWI570108B (pl)
UA (1) UA112899C2 (pl)
WO (1) WO2013178320A1 (pl)
ZA (1) ZA201409426B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015127234A1 (en) * 2014-02-20 2015-08-27 Board Of Regents, The University Of Texas System Use of ibrutinib to treat egfr mutant cancer
KR20160138756A (ko) * 2015-05-26 2016-12-06 연세대학교 산학협력단 신경줄기세포로부터 도파민 신경세포로의 분화 유도용 조성물 및 이를 이용하여 신경줄기세포로부터 도파민 신경세포로 분화시키는 방법
US10179132B2 (en) 2015-05-26 2019-01-15 Industry-Academic Cooperation Foundation, Yonsei University Composition for inducing differentiation of multipotent neural stem cells into dopaminergic neurons and method for inducing differentiation of multipotent neural stem cells into dopaminergic neurons by using the same
EP3425390B1 (en) 2016-11-25 2020-12-23 Genuv Inc. Composition for promoting differentiation of and protecting neural stem cells and method for inducing neural regeneration using same
KR101833412B1 (ko) 2017-07-24 2018-02-28 연세대학교 산학협력단 신경줄기세포로부터 도파민 신경세포로의 분화 유도용 조성물 및 이를 이용하여 신경줄기세포로부터 도파민 신경세포로 분화시키는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU756586C (en) * 1997-07-01 2004-01-29 Warner-Lambert Company 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
US6545030B1 (en) * 1999-01-13 2003-04-08 Warner-Lambert Company 1-heterocycle substituted diarylamines
EP1513840B1 (en) * 2002-05-31 2006-10-04 Bayer Pharmaceuticals Corporation Compounds and compositions for the treatment of diabetes and diabetes-related disorders
MX2007004781A (es) 2004-10-20 2007-05-11 Applied Research Systems Derivados de 3-arilamino piridina.
CN102134218A (zh) * 2009-06-15 2011-07-27 凯美隆(北京)药业技术有限公司 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂

Also Published As

Publication number Publication date
HRP20161135T1 (hr) 2016-11-04
EA201401341A1 (ru) 2015-05-29
KR20150022923A (ko) 2015-03-04
JP2015518013A (ja) 2015-06-25
IL235947A (en) 2016-08-31
HUE028850T2 (en) 2017-01-30
SI2855434T1 (sl) 2016-10-28
HK1206733A1 (en) 2016-01-15
ZA201409426B (en) 2017-05-31
ES2592860T3 (es) 2016-12-01
BR112014029838A2 (pt) 2017-06-27
RS55167B1 (sr) 2017-01-31
MY169266A (en) 2019-03-20
AU2013269994A1 (en) 2015-01-22
WO2013178320A1 (en) 2013-12-05
MX2014014520A (es) 2015-02-24
JP6280543B2 (ja) 2018-02-14
MX350295B (es) 2017-09-04
CL2014003285A1 (es) 2015-03-06
EA028059B1 (ru) 2017-10-31
US9260393B2 (en) 2016-02-16
PT2855434T (pt) 2016-10-04
LT2855434T (lt) 2016-12-12
TW201400459A (zh) 2014-01-01
AR091186A1 (es) 2015-01-14
NZ701103A (en) 2016-09-30
EP2855434A1 (en) 2015-04-08
US20150152059A1 (en) 2015-06-04
UA112899C2 (uk) 2016-11-10
EP2855434B1 (en) 2016-06-22
CA2875145A1 (en) 2013-12-05
TWI570108B (zh) 2017-02-11
CA2875145C (en) 2021-01-12
AU2013269994B2 (en) 2017-04-20
IL235947A0 (en) 2015-02-01
SG11201407842TA (en) 2014-12-30
DK2855434T3 (en) 2016-09-12
CN104334530A (zh) 2015-02-04

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