PL2697251T3 - Sposób kontrolowania głównego kompleksu struktur N-glikanu i wariantów kwasowych oraz zmienności w procesach biologicznych wytwarzających rekombinowane białka - Google Patents

Sposób kontrolowania głównego kompleksu struktur N-glikanu i wariantów kwasowych oraz zmienności w procesach biologicznych wytwarzających rekombinowane białka

Info

Publication number
PL2697251T3
PL2697251T3 PL12713737T PL12713737T PL2697251T3 PL 2697251 T3 PL2697251 T3 PL 2697251T3 PL 12713737 T PL12713737 T PL 12713737T PL 12713737 T PL12713737 T PL 12713737T PL 2697251 T3 PL2697251 T3 PL 2697251T3
Authority
PL
Poland
Prior art keywords
bioprocesses
variability
controlling
recombinant proteins
producing recombinant
Prior art date
Application number
PL12713737T
Other languages
English (en)
Inventor
Matjaz Koncilja
Vatroslav Spudic
Sasa Stojkovic
Matjaz Tisu
Original Assignee
Lek Pharmaceuticals D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44072576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2697251(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceuticals D.D. filed Critical Lek Pharmaceuticals D.D.
Publication of PL2697251T3 publication Critical patent/PL2697251T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
PL12713737T 2011-04-13 2012-04-12 Sposób kontrolowania głównego kompleksu struktur N-glikanu i wariantów kwasowych oraz zmienności w procesach biologicznych wytwarzających rekombinowane białka PL2697251T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11162193A EP2511293A1 (en) 2011-04-13 2011-04-13 A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
EP12713737.0A EP2697251B1 (en) 2011-04-13 2012-04-12 A method for controlling the main complex n-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
PCT/EP2012/056672 WO2012140138A1 (en) 2011-04-13 2012-04-12 A method for controlling the main complex n-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins

Publications (1)

Publication Number Publication Date
PL2697251T3 true PL2697251T3 (pl) 2019-08-30

Family

ID=44072576

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12713737T PL2697251T3 (pl) 2011-04-13 2012-04-12 Sposób kontrolowania głównego kompleksu struktur N-glikanu i wariantów kwasowych oraz zmienności w procesach biologicznych wytwarzających rekombinowane białka

Country Status (6)

Country Link
US (1) US9447188B2 (pl)
EP (2) EP2511293A1 (pl)
CA (1) CA2829061C (pl)
PL (1) PL2697251T3 (pl)
SI (1) SI2697251T1 (pl)
WO (1) WO2012140138A1 (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2064314A4 (en) 2006-09-13 2009-12-30 Abbott Lab IMPROVEMENTS TO CELL CULTURE
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
BRPI0920572A8 (pt) 2008-10-20 2015-10-27 Abbott Lab Inativação viral durante a purificação dos anticorpos
EP2350127B1 (en) 2008-10-20 2015-01-28 AbbVie Inc. Isolation and purification of antibodies using protein a affinity chromatography
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2830651A4 (en) 2013-03-12 2015-09-02 Abbvie Inc HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
MX2016002798A (es) 2013-09-05 2016-07-21 Genentech Inc Metodo para reutilizacion de cromatografia.
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3094639A4 (en) * 2014-01-13 2017-08-30 Magdalena Leszcyniecka Method for optimizing post-translational modifications on recombinant proteins
TR201610497T1 (tr) * 2014-01-29 2017-06-21 Lg Chemical Ltd Rekombi̇nant protei̇n galaktosi̇lasyonunu kültür ortaminin opti̇mi̇zasyonu vasitasiyla modüle etme yöntemi̇
WO2015128793A1 (en) * 2014-02-25 2015-09-03 Dr. Reddy’S Laboratories Limited A process for modifying high mannose and galactosylation content of a glycoprotein composition
WO2016162514A1 (en) * 2015-04-10 2016-10-13 Ares Trading S.A. Methods for modulating protein glycosylation profiles of recombinant proteins
HU231463B1 (hu) 2015-08-04 2024-01-28 Richter Gedeon Nyrt. Módszer rekombináns proteinek galaktóz tartalmának növelésére
EP3833688A1 (en) * 2018-08-10 2021-06-16 Genentech, Inc. Cell culture strategies for modulating protein glycosylation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2048621A (en) 1935-10-28 1936-07-21 Carrol T Potts Type clip
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5459031A (en) * 1993-11-05 1995-10-17 Amgen Inc. Methods for controlling sialic acid derivatives in recombinant glycoproteins
PT859841E (pt) 1995-08-18 2002-11-29 Morphosys Ag Bibliotecas de proteinas/ (poli) peptidos
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
EP1480515B1 (en) 2002-03-05 2005-10-19 ARTEMIS Pharmaceuticals GmbH Inbred embryonic stem-cell derived mice
PT2137655E (pt) 2007-04-16 2012-09-14 Momenta Pharmaceuticals Inc Produtos de glicoproteína definidos e métodos relacionados
KR101659458B1 (ko) 2007-12-27 2016-09-23 박스알타 인코퍼레이티드 세포 배양 방법
WO2010017338A1 (en) 2008-08-06 2010-02-11 Praxair Technology, Inc. METHOD FOR CONTROLLING pH, OSMOLALITY AND DISSOLVED CARBON DIOXIDE LEVELS IN A MAMMALIAN CELL CULTURE PROCESS TO ENHANCE CELL VIABILITY AND BIOLOGIC PRODUCT YIELD

Also Published As

Publication number Publication date
CA2829061A1 (en) 2012-10-18
US20140087423A1 (en) 2014-03-27
EP2511293A1 (en) 2012-10-17
WO2012140138A1 (en) 2012-10-18
US9447188B2 (en) 2016-09-20
EP2697251A1 (en) 2014-02-19
SI2697251T1 (sl) 2019-06-28
EP2697251B1 (en) 2019-02-27
CA2829061C (en) 2017-01-10

Similar Documents

Publication Publication Date Title
SI2697251T1 (sl) Postopek za kontroliranje glavnih struktur kompleksnih N-glikanov in kislinskih variant ter variabilnosti v bioloških postopkih, ki proizvajajo rekombinantne proteine
GB2492655B (en) Vehicle control system and method for controlling a vehicle
IL222507A0 (en) Heterodimeric antibody fc-containing proteins and methods for production thereof
EP2780521A4 (en) MECHANICAL EDGE ESTABLISHMENT SYSTEM AND METHOD FOR TILTING AND ADJUSTING IRREGULARITY
EP2666855A4 (en) RECOMBINANT YEAST AND METHOD FOR PRODUCING A SUBSTANCE THEREWITH
EP2774316A4 (en) REMOTE CONTROL AND METHOD OF OPERATION
EP2689399A4 (en) AUTONOMOUS BIOMETRIC AUTHORIZATION CONTROL DEVICE AND METHOD
EP2745171A4 (en) PROJECTOR AND CONTROL PROCESS THEREFOR
EP2774982A4 (en) PROCESS FOR SECRETION AND PRODUCTION OF PROTEINS
IL285503A (en) A method for producing high quality recombinant allergens in a plant
PL2753881T3 (pl) Element grzejny i sposób produkcji elementu grzejnego
ZA201307629B (en) Reflector element and method and system for the production thereof
PL2565181T3 (pl) Proces otrzymywania siarczanów i/lub sulfonianów w układach mikro-reakcyjnych
EP2746978A4 (en) LICENSE CONTROL METHOD AND SYSTEM THEREFOR
PL2599985T3 (pl) Sterownik stosunku powietrze/paliwo i sposób sterowania
PL2783850T3 (pl) Profil kompozytowy wykonany z włókien drzewnych, aluminium i tworzywa sztucznego oraz sposób wytwarzania tego profilu
IL234753B (en) A method for preparing a recombinant peptide and the prepared peptide
PT2744831T (pt) Proteína de fusão de transferrina-tumstatina e métodos para a produzir e utilizar
ZA201309255B (en) Method and regulator for adjusting the burn-through point in a sintering machine
EP2695947A4 (en) PROCESS FOR PRODUCING RECOMBINANT POLYPEPTIDE
ZA201307784B (en) Anti-cyanobacteria recombinant antibody polypeptide gene therefor and prepration method thereof
SG11201405721VA (en) Method of producing a recombinant peptide
EP2593410A4 (en) METHOD FOR TEMPERATURE CONTROL IN A CALCULATOR
HK1221742A1 (zh) 用於在原核細胞中重組生產多肽的方法
GB201107829D0 (en) A method of adjusting the position of a recess-mounted gas motor and a fitting for use in the method