PL243091A1 - Process for preparing novel derivatives of demycynozylotylosine - Google Patents
Process for preparing novel derivatives of demycynozylotylosineInfo
- Publication number
- PL243091A1 PL243091A1 PL24309183A PL24309183A PL243091A1 PL 243091 A1 PL243091 A1 PL 243091A1 PL 24309183 A PL24309183 A PL 24309183A PL 24309183 A PL24309183 A PL 24309183A PL 243091 A1 PL243091 A1 PL 243091A1
- Authority
- PL
- Poland
- Prior art keywords
- optionally substituted
- alkanoyl
- hydrogen
- phenylacetyl
- phenylpropionyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Emergency Protection Circuit Devices (AREA)
- Steroid Compounds (AREA)
Abstract
C-23-Modified derivatives of demycinosyltylosin (DMT) of the formula: <IMAGE> 1 wherein R is iodo, bromo, chloro, fluoro, -S-R4, azido, -NHR5, pyridinium or -OSO2CF3; R1 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl, phenylpropionyl, phenoxyacetyl or phenylthioacetyl; R2 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenylpropionyl; R3 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenoxyacetyl; R4 is hydrogen, optionally substituted C1-C6-alkyl, cyclohexyl, C1-C5-alkanoyl, optionally substituted phenyl or benzyl, or an optionally substituted heteroaryl group selected from imidazolyl, pyrazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, thienyl and furanyl; and R5 is hydrogen or an acyl group selected from optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenylpropionyl; and salts thereof are useful antibiotics or intermediates to antibiotics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/399,656 US4452784A (en) | 1982-07-19 | 1982-07-19 | C-23-Modified derivatives of DMT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL243091A1 true PL243091A1 (en) | 1984-07-16 |
Family
ID=23580425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL24309183A PL243091A1 (en) | 1982-07-19 | 1983-07-19 | Process for preparing novel derivatives of demycynozylotylosine |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4452784A (en) |
| EP (1) | EP0099746B1 (en) |
| JP (1) | JPS5931796A (en) |
| KR (1) | KR850000966B1 (en) |
| AT (1) | ATE23047T1 (en) |
| AU (1) | AU1693583A (en) |
| CA (1) | CA1202964A (en) |
| DD (1) | DD210059A5 (en) |
| DE (1) | DE3367104D1 (en) |
| DK (1) | DK330483D0 (en) |
| ES (1) | ES8504841A1 (en) |
| FI (1) | FI832604A (en) |
| GB (1) | GB2123827B (en) |
| GR (1) | GR78387B (en) |
| NZ (1) | NZ204940A (en) |
| PH (1) | PH19727A (en) |
| PL (1) | PL243091A1 (en) |
| PT (1) | PT77040A (en) |
| ZA (1) | ZA835216B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58219197A (en) * | 1982-06-15 | 1983-12-20 | Sanraku Inc | Derivative of macrolide antibiotic |
| US4436729A (en) * | 1982-06-30 | 1984-03-13 | Schering Corporation | 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use |
| US4629786A (en) * | 1983-02-28 | 1986-12-16 | Eli Lilly And Company | C-20- and C-23 modified macrolide derivatives |
| US4656258A (en) * | 1983-03-03 | 1987-04-07 | Eli Lilly And Company | Macrocin derivatives |
| JPS62103098A (en) * | 1985-05-13 | 1987-05-13 | Microbial Chem Res Found | Tylosin derivative |
| OA08732A (en) * | 1987-05-06 | 1989-03-31 | Adir | New macrolide derivatives, their preparation process and pharmaceutical compositions containing them. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE667952A (en) * | 1964-08-05 | |||
| US4358584A (en) * | 1979-05-23 | 1982-11-09 | Eli Lilly And Company | Antibiotics A6888C and A6888X |
| JPS56122397A (en) * | 1980-02-29 | 1981-09-25 | Satoshi Omura | Marcolides |
| US4321361A (en) * | 1980-06-12 | 1982-03-23 | Eli Lilly And Company | Demycinosyltylosin and process for its production |
| ZA813578B (en) * | 1980-06-12 | 1983-01-26 | Lilly Co Eli | Macrolide antibiotics |
| US4438109A (en) * | 1980-07-25 | 1984-03-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Tylosin derivatives |
| US4304856A (en) * | 1980-11-10 | 1981-12-08 | Eli Lilly And Company | Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin |
| US4341770A (en) * | 1981-04-20 | 1982-07-27 | Eli Lilly And Company | Method of controlling ureaplasma infections |
| US4341771A (en) * | 1981-04-20 | 1982-07-27 | Eli Lilly And Company | Method of controlling Pasteurella infections |
| AU551142B2 (en) * | 1981-07-09 | 1986-04-17 | Zaidan Hojin Biseibutsu Kagaku Kenkyukai | Tylosin derivatives |
| JPS58219197A (en) * | 1982-06-15 | 1983-12-20 | Sanraku Inc | Derivative of macrolide antibiotic |
| US4436729A (en) * | 1982-06-30 | 1984-03-13 | Schering Corporation | 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use |
-
1982
- 1982-07-19 US US06/399,656 patent/US4452784A/en not_active Expired - Fee Related
-
1983
- 1983-07-18 GB GB08319306A patent/GB2123827B/en not_active Expired
- 1983-07-18 AU AU16935/83A patent/AU1693583A/en not_active Abandoned
- 1983-07-18 DK DK3304/83A patent/DK330483D0/en not_active Application Discontinuation
- 1983-07-18 DE DE8383304153T patent/DE3367104D1/en not_active Expired
- 1983-07-18 JP JP58131793A patent/JPS5931796A/en active Pending
- 1983-07-18 KR KR1019830003274A patent/KR850000966B1/en active IP Right Grant
- 1983-07-18 PH PH29239A patent/PH19727A/en unknown
- 1983-07-18 ZA ZA835216A patent/ZA835216B/en unknown
- 1983-07-18 CA CA000432587A patent/CA1202964A/en not_active Expired
- 1983-07-18 ES ES524197A patent/ES8504841A1/en not_active Expired
- 1983-07-18 NZ NZ204940A patent/NZ204940A/en unknown
- 1983-07-18 EP EP83304153A patent/EP0099746B1/en not_active Expired
- 1983-07-18 AT AT83304153T patent/ATE23047T1/en not_active IP Right Cessation
- 1983-07-18 FI FI832604A patent/FI832604A/en not_active Application Discontinuation
- 1983-07-18 GR GR71960A patent/GR78387B/el unknown
- 1983-07-18 PT PT77040A patent/PT77040A/en unknown
- 1983-07-19 PL PL24309183A patent/PL243091A1/en unknown
- 1983-07-19 DD DD83253195A patent/DD210059A5/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB8319306D0 (en) | 1983-08-17 |
| KR850000966B1 (en) | 1985-07-02 |
| GB2123827A (en) | 1984-02-08 |
| US4452784A (en) | 1984-06-05 |
| ZA835216B (en) | 1984-03-28 |
| FI832604A0 (en) | 1983-07-18 |
| GB2123827B (en) | 1986-07-30 |
| ES524197A0 (en) | 1985-05-01 |
| PH19727A (en) | 1986-06-17 |
| EP0099746A1 (en) | 1984-02-01 |
| FI832604A (en) | 1984-01-20 |
| DE3367104D1 (en) | 1986-11-27 |
| PT77040A (en) | 1983-08-01 |
| NZ204940A (en) | 1985-11-08 |
| DD210059A5 (en) | 1984-05-30 |
| JPS5931796A (en) | 1984-02-20 |
| DK330483D0 (en) | 1983-07-18 |
| ES8504841A1 (en) | 1985-05-01 |
| KR840005462A (en) | 1984-11-12 |
| CA1202964A (en) | 1986-04-08 |
| AU1693583A (en) | 1984-01-26 |
| GR78387B (en) | 1984-09-26 |
| EP0099746B1 (en) | 1986-10-22 |
| ATE23047T1 (en) | 1986-11-15 |
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