PL243091A1 - Process for preparing novel derivatives of demycynozylotylosine - Google Patents

Process for preparing novel derivatives of demycynozylotylosine

Info

Publication number
PL243091A1
PL243091A1 PL24309183A PL24309183A PL243091A1 PL 243091 A1 PL243091 A1 PL 243091A1 PL 24309183 A PL24309183 A PL 24309183A PL 24309183 A PL24309183 A PL 24309183A PL 243091 A1 PL243091 A1 PL 243091A1
Authority
PL
Poland
Prior art keywords
optionally substituted
alkanoyl
hydrogen
phenylacetyl
phenylpropionyl
Prior art date
Application number
PL24309183A
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL243091A1 publication Critical patent/PL243091A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Train Traffic Observation, Control, And Security (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Steroid Compounds (AREA)

Abstract

C-23-Modified derivatives of demycinosyltylosin (DMT) of the formula: <IMAGE> 1 wherein R is iodo, bromo, chloro, fluoro, -S-R4, azido, -NHR5, pyridinium or -OSO2CF3; R1 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl, phenylpropionyl, phenoxyacetyl or phenylthioacetyl; R2 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenylpropionyl; R3 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenoxyacetyl; R4 is hydrogen, optionally substituted C1-C6-alkyl, cyclohexyl, C1-C5-alkanoyl, optionally substituted phenyl or benzyl, or an optionally substituted heteroaryl group selected from imidazolyl, pyrazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, thienyl and furanyl; and R5 is hydrogen or an acyl group selected from optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenylpropionyl; and salts thereof are useful antibiotics or intermediates to antibiotics.
PL24309183A 1982-07-19 1983-07-19 Process for preparing novel derivatives of demycynozylotylosine PL243091A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/399,656 US4452784A (en) 1982-07-19 1982-07-19 C-23-Modified derivatives of DMT

Publications (1)

Publication Number Publication Date
PL243091A1 true PL243091A1 (en) 1984-07-16

Family

ID=23580425

Family Applications (1)

Application Number Title Priority Date Filing Date
PL24309183A PL243091A1 (en) 1982-07-19 1983-07-19 Process for preparing novel derivatives of demycynozylotylosine

Country Status (19)

Country Link
US (1) US4452784A (en)
EP (1) EP0099746B1 (en)
JP (1) JPS5931796A (en)
KR (1) KR850000966B1 (en)
AT (1) ATE23047T1 (en)
AU (1) AU1693583A (en)
CA (1) CA1202964A (en)
DD (1) DD210059A5 (en)
DE (1) DE3367104D1 (en)
DK (1) DK330483D0 (en)
ES (1) ES8504841A1 (en)
FI (1) FI832604A (en)
GB (1) GB2123827B (en)
GR (1) GR78387B (en)
NZ (1) NZ204940A (en)
PH (1) PH19727A (en)
PL (1) PL243091A1 (en)
PT (1) PT77040A (en)
ZA (1) ZA835216B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219197A (en) * 1982-06-15 1983-12-20 Sanraku Inc Derivative of macrolide antibiotic
US4436729A (en) * 1982-06-30 1984-03-13 Schering Corporation 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
US4656258A (en) * 1983-03-03 1987-04-07 Eli Lilly And Company Macrocin derivatives
JPS62103098A (en) * 1985-05-13 1987-05-13 Microbial Chem Res Found Tylosin derivative
OA08732A (en) * 1987-05-06 1989-03-31 Adir New macrolide derivatives, their preparation process and pharmaceutical compositions containing them.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE667952A (en) * 1964-08-05
US4358584A (en) * 1979-05-23 1982-11-09 Eli Lilly And Company Antibiotics A6888C and A6888X
JPS56122397A (en) * 1980-02-29 1981-09-25 Satoshi Omura Marcolides
US4321361A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company Demycinosyltylosin and process for its production
ZA813578B (en) * 1980-06-12 1983-01-26 Lilly Co Eli Macrolide antibiotics
US4438109A (en) * 1980-07-25 1984-03-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Tylosin derivatives
US4304856A (en) * 1980-11-10 1981-12-08 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
US4341770A (en) * 1981-04-20 1982-07-27 Eli Lilly And Company Method of controlling ureaplasma infections
US4341771A (en) * 1981-04-20 1982-07-27 Eli Lilly And Company Method of controlling Pasteurella infections
AU551142B2 (en) * 1981-07-09 1986-04-17 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Tylosin derivatives
JPS58219197A (en) * 1982-06-15 1983-12-20 Sanraku Inc Derivative of macrolide antibiotic
US4436729A (en) * 1982-06-30 1984-03-13 Schering Corporation 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use

Also Published As

Publication number Publication date
GB8319306D0 (en) 1983-08-17
KR850000966B1 (en) 1985-07-02
GB2123827A (en) 1984-02-08
US4452784A (en) 1984-06-05
ZA835216B (en) 1984-03-28
FI832604A0 (en) 1983-07-18
GB2123827B (en) 1986-07-30
ES524197A0 (en) 1985-05-01
PH19727A (en) 1986-06-17
EP0099746A1 (en) 1984-02-01
FI832604A (en) 1984-01-20
DE3367104D1 (en) 1986-11-27
PT77040A (en) 1983-08-01
NZ204940A (en) 1985-11-08
DD210059A5 (en) 1984-05-30
JPS5931796A (en) 1984-02-20
DK330483D0 (en) 1983-07-18
ES8504841A1 (en) 1985-05-01
KR840005462A (en) 1984-11-12
CA1202964A (en) 1986-04-08
AU1693583A (en) 1984-01-26
GR78387B (en) 1984-09-26
EP0099746B1 (en) 1986-10-22
ATE23047T1 (en) 1986-11-15

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