PL222258B1 - Control fungi (fusarium) agent, its preparation and its use - Google Patents

Description

(12) PATENT DESCRIPTION (19) PL (11) 222258 (13) B1 (21) Application number: 395602 ^{(51) Int.Cl.}

A01N 33/12 (2006.01) A01P 3/00 (2006.01) D21H 17/07 (2006.01) (22) Date of notification: 11.07.2011

Use of benzalkonium nitrate, benzalkonium DL-lactate or didecyldimethylammonium DL-lactate

(73) The right holder of the patent: UNIVERSITY OF TECHNOLOGY OF LODZ, Łódź, PL (72) Inventor (s): (43) Application was announced: JULIUSZ PERNAK, Poznań, PL 21.01.2013 BUP 02/13 BARTOSZ MARKIEWICZ, Poznań, PL MARIUSZ KOT, Poznań, PL KAZIMIERZ PRZYBYSZ, Lodz, PL EWA DRZEWIŃSKA, Łódź, PL (45) The grant of the patent was announced: AGNIESZKA WYSOCKA-ROBAK, Lodz, PL 29.07.2016 WUP 07/16 PIOTR PRZYBYSZ, Łódź, PL ANNA KOZIRÓG, Lodz, PL (74) Representative: item. stalemate. Ewa Kaczur-Kaczyńska

PL 222 258 B1

Description of the invention

The present invention relates to the use of benzalkonium nitrate, benzalkonium DL-lactate or didecyldimethylammonium DL-lactate for the control of fungi.

The paper products contain at least 50% plant fibers, especially wood fibers. These fibers contain cellulose, which is an excellent material for the development of microorganisms. Microorganisms cause enzymatic decomposition of wood fibers into simple compounds which they use in their own life processes. The destructive action of microorganisms begins in the production process of paper products, i.e. in raw materials (wood, pulp and waste paper), in circulating water, as well as in dyes, adhesives or fillers. The quality of the processed pulp affects the final product, its poor microbiological condition makes the paper weak and brittle.

Filamentous fungi develop particularly easily on paper, quickly adapting to unfavorable environmental conditions - variable humidity, pH, temperature. The species that exhibit cellulolytic and lipolytic properties, causing changes in the strength of the paper, discoloration and stains, are mainly responsible for the biodegradation of paper. Paper collected and stored in museums, libraries or archives in conditions of high humidity is particularly exposed to the development of various species of fungi. The most frequently isolated from library materials include: Aspergillus niger, Aspergillus terreus, Penicillium chrysogenum, Penicillium aurantiogriseum, Trichoderma viride, Chaetomium globusom.

Moisture is of particular importance when storing paper products. When the relative humidity reaches 30%, the paper product dries up and crumbles. On the other hand, when the humidity exceeds 65%, it begins to attack by fungi, and above 75% by bacteria. The most dangerous, however, are even short-term fluctuations in relative humidity above 90%, as is the case with flooding of books and documents. If they do not dry quickly to a relative humidity below 65%, bacteria and fungi can quickly develop after a few hours. Flooding the paper product with water results in the formation of difficult to remove stains on moist papers.

So far, in order to limit the development of filamentous fungi, both in the paper production process and in finished products, as well as during storage of these products in libraries, archives or museums, various types of biocides, including ionic liquids, have been used.

The use of the agent in the form of a mixture of dialkyldimethylammonium nitrates and / or alkylbenzyldimethylammonium nitrates (V) with polyglycols and / or quaternary ammonium halogens containing pigments, fragrances and fillers for surface protection and / or or plunging wood against the action of Scleophoma pityophila, Trametes versicolor, Coniophora puteana, Aspergillus niger, Penicillium funiculosum, Trichoderma viride, Alternaria alternata, Paecilomyces varioti and Chaetomium globosum strains growing on pine wood.

Patent PL No. 208,336 discloses the use of an agent in the form of 100% alcohol, chloroform or ester nitrate (V) dialkyldimethylammonium nitrates and / or alkylbenzyldimethylammonium nitrates (V) containing additives such as pigments, fragrances and fillers to combat strains of Sclerophoma pityophila, Trametes Versicolor, Coniophora puteana, Aspergillus niger, Penicillium funiculosum, Trichoderma viride, Alternaria alternata, Paecilomyces varioti, Chaetomium globosum, growing on pine wood.

Effective action of benzalkonium lactate in the form of the L (+), D (-) isomer and DL racemate in the form of an aqueous solution with a concentration of 0.01% to 80% against Candida albicans ATCC 10231 and Rhodotorula rubra (Demml 1889, Lodder 1934), it is known from the patent description PL No. 208,416, while the effective action against these fungal strains didecyldimethylammonium lactate in the form of the L (+), D (-) isomer and the DL racemate, in the form of an aqueous solution with a concentration of 0.01% up to 80% is disclosed in PL Patent No. 208,417.

Use of benzalkonium nitrate, benzalkonium DL-lactate or didecyldimethylammonium DL-lactate, in the form of solutions in water, alcohol or a mixture of water and alcohol, further containing a deacidifying substance, a surface tension lowering substance, preferably in the form of a non-ionic surfactant, the colorant and the fragrance for controlling fungi according to the invention are solutions of these

The compounds are used to protect paper or cardboard against the action of strains of filamentous fungi, such as Aspergillus niger ATCC 16404, Penicillium chrysogenum ATCC 60739, Penicillium aurantiogriseum ATCC 18382, Aspergillus terreus ATCC 10020.

Solutions of benzalkonium nitrate, benzalkonium DL-lactate or didecyldimethylammonium DL-lactate in a mixture of water and alcohol with a weight ratio of 1: 9 components are used. Solutions containing 1-75% by weight of these compounds and moreover at least 0.001% by weight of the deacidifying agent, at least 0.0001% by weight of the surface tension reducing agent, at least 0.00001% by weight of the coloring agent and at least 0.00001% by weight of the dye are used. by weight of the fragrance. Solutions of the compounds used are sprayed onto the surface of the security product or the security product is impregnated with this solution in a bath, and in the case of securing paper, solutions of these compounds are also applied in a solution sizing paper surface or in a pigment mixture for coating paper.

The effectiveness of using solutions of benzalkonium nitrate (V), benzalkonium DL-lactate or didecyldimethylammonium DL-lactate to protect paper or cardboard against the action of the above strains of filamentous fungi competes with the effectiveness of biocides currently used for this purpose, and the solutions of these compounds are characterized by a low resilience vapors and no or little toxicity to warm-blooded organisms. Moreover, the use of substrates from large-scale production for the synthesis of the compounds used causes that the price of solutions of these compounds is lower than the currently used biocides.

The following examples illustrate the subject matter of the invention.

P r z k ł a d I

A composition was prepared containing 25 g DL-benzalkonium lactate 0.1 g nonionic surfactant, 50 g ethanol, 925 g water and 0.01 g indigo carmine.

This measure was prepared as follows.

g of DL-benzalkonium lactate are taken up in 50 g of ethanol, then 925 g of water are added with vigorous stirring at room temperature. After 2 minutes of stirring, 1 g of the non-ionic surfactant - sorbitan tristearate and 0.01 g of indigo carmine as a dye were successively introduced into the prepared solution, while stirring.

The activity of the obtained preparation is shown in Table 1. The useful life of the preparation was at least 30 days.

Example II g of didecyldimethylammonium DL-lactate was introduced into 50 g of ethanol, then 925 g of water were added while stirring at room temperature. After 2 minutes of stirring, 0.1 g of synthetic fatty alcohol polyoxyethylene ether and 0.01 g of fluorescein were added while stirring.

The activity of the obtained preparation is shown in Table 1. The useful life of the preparation was at least 30 days.

P r x l a d III

980 g of water was introduced into 10 g of didecyldimethylammonium lactate, and then 10 g of isopropanol was added with constant stirring at room temperature. After 2 minutes, 0.1 g of an ethanolic solution of orange yellow S.

The activity of the obtained preparation is shown in Table 1. The useful life of the preparation was at least 30 days.

Example IV g of benzalkonium nitrate was dissolved in 990 g of water while being vigorously stirred at room temperature for 2 minutes. After this time, also while stirring, 0.1 g of nonylphenol oxyethylate (nonylphenol ethoxylate with 8 moles of oxirane) was introduced and stirred for a further 5 minutes, then transferred to an amber glass bottle.

The activity of the obtained preparation is shown in Table 1. The useful life of the preparation was at least 20 days.

EXAMPLE 5 g of benzalkonium nitrate are introduced into 950 g of water, and then 25 g of isopropyl alcohol are added with vigorous stirring at room temperature. After 2 minutes, 0.01 g of riboflavin and 0.1 g of nonylphenyl polyoxyethylene glycol ether were successively added while stirring, and the mixture was stirred for another 5 minutes. Finally, another 0.01 g of sodium carbonate was added as

PL 222 258 B1 of a de-acidifying substance. The activity of the obtained preparation is shown in Table 1. The useful life of the preparation was at least 60 days.

P r x l a d VI

In order to disinfect the surface of the paper infected with Penicillium aurantiogriseum fungus, a preparation containing 2.5% DL-benzalkonium lactate, 945 g of water, 30 g of ethyl alcohol, 0.0001% of synthetic fatty alcohol polyoxyethylene ether and 0.0001% of fluorescein was used.

The preparation was sprayed 25 cm above the surface to be cleaned, in the amount of 20 g / m2. After 30 seconds, no live forms of the fungus were observed on the paper surface.

Table 1 shows the activity of the ionic liquids used in Examples 1-5 against filamentous fungi. Minimum Conidia Inhibitory Concentration (MIC).

T a b l i c a 1

Ionic liquid Filamentous fungus strains [BA] [DL-ML] [DDA] [DL-ML] [BA] [NOa] Aspergillus niger ATCC 16404 78 19.5 39 Penicillium chrysogenum ATCC 60739 78 78 156 Penicillium aurantiogriseum ATCC 18382 78 39 78 Aspergillus terreus ATCC 10020 39 39 39

[BA] [DL-ML] - DL-benzalkonium lactate,

[DDA] [DL-ML] - Didecyldimethylammonium DL-lactate, [BA] [NO ₃ ] - benzalkonium nitrate.

Claims (4)

Patent claims 1. Use of benzalkonium nitrate, benzalkonium DL-lactate or didecyldimethylammonium DL-lactate, in the form of solutions in water, alcohol or a mixture of water and alcohol, further containing a deacidifying substance, a surface tension lowering substance, preferably in the form of a non-ionic surfactant , a colorant and a perfume for combating fungi, characterized in that the solutions of these compounds are used to protect paper or cardboard against the action of filamentous fungi such as Aspergillus niger ATCC 16404, Penicillium chrysogenum ATCC 60739, Penicillium aurantiogriseum ATCC 18382, Aspergillus terreus terreus terreus 10020. 2. The use according to claim 1 2. A method according to claim 1, characterized in that the solutions of the compounds defined in claim 1 are used in a mixture of water and alcohol with a weight ratio of the components of 1: 9. 3. Use according to claim 1 3. A method as claimed in claim 1, characterized in that the solutions of the compounds according to claim 1 contain 1-75% by weight of these compounds, moreover at least 0.001% by weight of a deacidifying agent, at least 0.0001% by weight of the surface tension lowering substance, at least 0.00001 % by weight of a coloring agent, and at least 0.00001% by weight of a perfume. 4. Use according to claim 1 3. The method of claim 1, characterized in that the solutions of the compounds defined in claim 1 are sprayed onto the surface of the security product or the security product is impregnated with this solution in the bath, and in the case of securing paper, solutions of these compounds are also applied in a solution sealing the surface of the paper or in a pigment mixture. for coating paper.