PL2139484T3 - Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha - Google Patents

Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Info

Publication number
PL2139484T3
PL2139484T3 PL08742677T PL08742677T PL2139484T3 PL 2139484 T3 PL2139484 T3 PL 2139484T3 PL 08742677 T PL08742677 T PL 08742677T PL 08742677 T PL08742677 T PL 08742677T PL 2139484 T3 PL2139484 T3 PL 2139484T3
Authority
PL
Poland
Prior art keywords
methods
treating cancer
pi3k alpha
pyridopyrimidinone
inhibitors
Prior art date
Application number
PL08742677T
Other languages
Polish (pl)
Inventor
Peter Lamb
David Matthews
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of PL2139484T3 publication Critical patent/PL2139484T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL08742677T 2007-04-10 2008-04-09 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha PL2139484T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92289907P 2007-04-10 2007-04-10
EP08742677.1A EP2139484B9 (en) 2007-04-10 2008-04-09 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha
PCT/US2008/004573 WO2008124161A1 (en) 2007-04-10 2008-04-09 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Publications (1)

Publication Number Publication Date
PL2139484T3 true PL2139484T3 (en) 2013-12-31

Family

ID=39627802

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08742677T PL2139484T3 (en) 2007-04-10 2008-04-09 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Country Status (31)

Country Link
US (1) US8513266B2 (en)
EP (1) EP2139484B9 (en)
JP (3) JP2010523670A (en)
KR (1) KR101626435B1 (en)
CN (2) CN102727498B (en)
AU (1) AU2008236562B2 (en)
BR (1) BRPI0810206A2 (en)
CA (1) CA2683641C (en)
CO (1) CO6251254A2 (en)
CR (1) CR11100A (en)
DK (1) DK2139484T3 (en)
DO (1) DOP2009000243A (en)
EA (1) EA020022B1 (en)
EC (1) ECSP099724A (en)
ES (1) ES2430614T3 (en)
HN (1) HN2009003002A (en)
HR (1) HRP20130688T1 (en)
IL (1) IL201284A (en)
MA (1) MA31358B1 (en)
ME (1) ME00936B (en)
MX (1) MX2009010930A (en)
MY (1) MY150697A (en)
NZ (1) NZ580110A (en)
PL (1) PL2139484T3 (en)
PT (1) PT2139484E (en)
RS (1) RS52939B (en)
SI (1) SI2139484T1 (en)
TN (1) TN2009000400A1 (en)
UA (1) UA100979C2 (en)
WO (1) WO2008124161A1 (en)
ZA (1) ZA200906764B (en)

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SA08280783B1 (en) * 2007-01-11 2011-04-24 استرازينيكا ايه بي Pyridopyrimidine Derivatives as PDE4 Inhibitors
UA100979C2 (en) 2007-04-10 2013-02-25 Экселиксис, Инк. Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha
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WO2010022125A1 (en) 2008-08-20 2010-02-25 Schering Corporation Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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AR080151A1 (en) 2010-02-09 2012-03-14 Exelixis Inc METHODS TO TREAT CANCER USING PI 3K PYRIDOPIRIMIDINONE INHIBITORS AND MTOR IN COMBINATION WITH AUTOPHAGIA INHIBITORS
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WO2013056067A1 (en) * 2011-10-13 2013-04-18 Exelixis, Inc. Compounds for use in the treatment of basal cell carcinoma
PH12014500973A1 (en) 2011-11-01 2014-06-16 Exelixis Inc Phosphatidylinositol 3-kinase inhibitors for the treatment of lymphoproliferative malignancies
JP6126615B2 (en) * 2011-11-11 2017-05-10 インテリカイン， エルエルシー Combinations of kinase inhibitors and their use
CA2860051A1 (en) * 2011-12-27 2013-07-04 Kadmon Corporation, Llc Methods for treatment of breast cancer nonresponsive to trastuzumab
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20150182490A1 (en) 2012-06-26 2015-07-02 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
US8980259B2 (en) * 2012-07-20 2015-03-17 Novartis Ag Combination therapy
AR092045A1 (en) 2012-08-07 2015-03-18 Novartis Ag PHARMACEUTICAL COMBINATIONS
KR20160061911A (en) 2013-04-08 2016-06-01 데니스 엠. 브라운 Therapeutic benefit of suboptimally administered chemical compounds
US9950194B2 (en) 2014-09-09 2018-04-24 Mevion Medical Systems, Inc. Patient positioning system
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PE20190475A1 (en) * 2016-08-15 2019-04-04 Pfizer CDK2 / 4/6 INHIBITORS
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Also Published As

Publication number Publication date
CN102727498B (en) 2016-08-03
ECSP099724A (en) 2010-03-31
MX2009010930A (en) 2010-01-20
EP2139484A1 (en) 2010-01-06
IL201284A0 (en) 2010-05-31
CR11100A (en) 2010-01-19
NZ580110A (en) 2012-06-29
US20100209420A1 (en) 2010-08-19
RS52939B (en) 2014-02-28
EP2139484B8 (en) 2013-08-21
CA2683641A1 (en) 2008-10-16
SI2139484T1 (en) 2013-10-30
AU2008236562B2 (en) 2013-11-07
HK1139863A1 (en) 2010-09-30
WO2008124161A1 (en) 2008-10-16
HRP20130688T1 (en) 2013-09-30
DK2139484T3 (en) 2013-10-21
EP2139484B9 (en) 2014-06-11
IL201284A (en) 2016-06-30
ES2430614T3 (en) 2013-11-21
CO6251254A2 (en) 2011-02-21
PT2139484E (en) 2013-10-31
KR101626435B1 (en) 2016-06-01
US8513266B2 (en) 2013-08-20
BRPI0810206A2 (en) 2014-10-21
DOP2009000243A (en) 2010-10-31
TN2009000400A1 (en) 2010-12-31
MY150697A (en) 2014-02-28
ME00936B (en) 2012-06-20
JP2014034576A (en) 2014-02-24
EP2139484B1 (en) 2013-07-17
UA100979C2 (en) 2013-02-25
AU2008236562A1 (en) 2008-10-16
EA020022B1 (en) 2014-08-29
EA200970932A1 (en) 2010-04-30
JP2014139217A (en) 2014-07-31
KR20100016354A (en) 2010-02-12
HN2009003002A (en) 2014-03-24
CN102727498A (en) 2012-10-17
CN101715345A (en) 2010-05-26
JP2010523670A (en) 2010-07-15
CA2683641C (en) 2016-08-16
MA31358B1 (en) 2010-05-03
ZA200906764B (en) 2010-08-25

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