PL2082045T3 - Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów - Google Patents

Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów

Info

Publication number
PL2082045T3
PL2082045T3 PL07821516T PL07821516T PL2082045T3 PL 2082045 T3 PL2082045 T3 PL 2082045T3 PL 07821516 T PL07821516 T PL 07821516T PL 07821516 T PL07821516 T PL 07821516T PL 2082045 T3 PL2082045 T3 PL 2082045T3
Authority
PL
Poland
Prior art keywords
gene expression
codon usage
reducing gene
modified codon
modified
Prior art date
Application number
PL07821516T
Other languages
English (en)
Inventor
Andrea Herold
Corinna Klopprogge
Hartwig Schröder
Oskar Zelder
Weol Kyu Jeong
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of PL2082045T3 publication Critical patent/PL2082045T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL07821516T 2006-10-24 2007-10-18 Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów PL2082045T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06122882 2006-10-24
PCT/EP2007/061151 WO2008049781A1 (en) 2006-10-24 2007-10-18 Method of reducing gene expression using modified codon usage
EP07821516.7A EP2082045B1 (en) 2006-10-24 2007-10-18 Method of reducing gene expression using modified codon usage

Publications (1)

Publication Number Publication Date
PL2082045T3 true PL2082045T3 (pl) 2015-07-31

Family

ID=38969443

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07821516T PL2082045T3 (pl) 2006-10-24 2007-10-18 Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów

Country Status (6)

Country Link
US (1) US20100041107A1 (pl)
EP (1) EP2082045B1 (pl)
ES (1) ES2539280T3 (pl)
HU (1) HUE025440T2 (pl)
PL (1) PL2082045T3 (pl)
WO (1) WO2008049781A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9476032B2 (en) 2007-03-30 2016-10-25 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines
PL2235194T3 (pl) * 2008-01-23 2011-12-30 Basf Se Sposób fermentacyjnego wytwarzania 1,5- diaminopentanu
MX2010011720A (es) * 2008-04-30 2010-11-30 Evonik Degussa Gmbh Procedimiento de produccion de metionina usando microorganismos con actividad reducida de isocitrato deshidrogenasa.
JP5395893B2 (ja) * 2008-04-30 2014-01-22 ビーエーエスエフ ソシエタス・ヨーロピア 低下したイソクエン酸デヒドロゲナーゼ活性を有する微生物を使用するファインケミカルの製造方法
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
EP2534264A4 (en) * 2010-02-09 2014-02-26 Univ Columbia METHOD FOR CHANGING A POLYPEPTIDE EXPRESSION AND SOLUBILITY
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
US9169502B2 (en) * 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102013741B1 (ko) * 2017-02-24 2019-08-23 한국과학기술원 메티오닌 생합성능이 향상된 변이세포
EP3783106A4 (en) * 2018-04-20 2022-01-05 Ajinomoto Co., Inc. PROCESS FOR THE SECRETION OF A PROTEIN
EP4598947A2 (en) * 2022-10-07 2025-08-13 SENS Research Foundation Allotopic expression of mtdna genes

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドｐｃｇ２
GB2165546B (en) 1984-08-21 1989-05-17 Asahi Chemical Ind A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
DE4120867A1 (de) 1991-06-25 1993-01-07 Agfa Gevaert Ag Fotografisches verarbeitungsverfahren und vorrichtung dafuer
DE19924365A1 (de) * 1999-05-27 2000-11-30 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren und für das accDA Gen codierende Nukleotidsequenzen
US6780405B1 (en) * 2000-04-28 2004-08-24 Avant Immunotherapeutics, Inc. Regulated antigen delivery system (RADS)
EP1307475A1 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
WO2002012504A1 (en) * 2000-08-10 2002-02-14 Degussa Ag Nucleotide sequences which code for the lysr2 gene
DE10046870A1 (de) 2000-09-20 2002-03-28 Basf Ag Verfahren zur Veränderung des Genoms von Corynebakterien
EP1375664B1 (en) * 2001-03-30 2009-11-04 Ajinomoto Co., Inc. Method for the secretion and production of protein
WO2004042059A1 (en) 2002-11-08 2004-05-21 The University Of Queensland A method for optimising gene expression using synonymous codon optimisation
DE10359594A1 (de) 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
DE10359595A1 (de) * 2003-12-18 2005-07-28 Basf Ag Pgro-Expressionseinheiten
DE102004035065A1 (de) 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
JP2009501512A (ja) * 2005-06-17 2009-01-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド 改良されたアミノ酸及び代謝産物生合成
WO2007005053A1 (en) * 2005-06-30 2007-01-11 Codon Devices, Inc. Hierarchical assembly methods for genome engineering
US20070212711A1 (en) * 2005-07-16 2007-09-13 Basf Aktiengesellschaft P1-34 Expression Units
AU2006269864A1 (en) 2005-07-18 2007-01-25 Evonik Degussa Gmbh Methionine producing recombinant microorganisms
JP2009504172A (ja) 2005-08-18 2009-02-05 ビーエーエスエフ ソシエタス・ヨーロピア 向上したメチオニン合成効率を有する微生物
US20080051317A1 (en) * 2005-12-15 2008-02-28 George Church Polypeptides comprising unnatural amino acids, methods for their production and uses therefor

Also Published As

Publication number Publication date
ES2539280T3 (es) 2015-06-29
EP2082045A1 (en) 2009-07-29
US20100041107A1 (en) 2010-02-18
EP2082045B1 (en) 2015-03-18
WO2008049781A1 (en) 2008-05-02
HUE025440T2 (en) 2016-04-28

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