PL2000B1 - Method of obtaining vaccinates from bacteria - Google Patents
Method of obtaining vaccinates from bacteria Download PDFInfo
- Publication number
- PL2000B1 PL2000B1 PL2000A PL200024A PL2000B1 PL 2000 B1 PL2000 B1 PL 2000B1 PL 2000 A PL2000 A PL 2000A PL 200024 A PL200024 A PL 200024A PL 2000 B1 PL2000 B1 PL 2000B1
- Authority
- PL
- Poland
- Prior art keywords
- bacteria
- hexamethylenetetramine
- vaccinates
- obtaining
- compounds
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims description 7
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 16
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 9
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 229960004011 methenamine Drugs 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010046865 Vaccinia virus infection Diseases 0.000 description 3
- -1 hexamethylenetetramine compound Chemical class 0.000 description 3
- 208000007089 vaccinia Diseases 0.000 description 3
- 230000032683 aging Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Description
Wodniste splawiny bakterji, sluzace ja¬ ko wakcyny, wykazuja te wade, ze bakte- rje stopniowo ulegaja rozkladowi, przez co dzialalnosc wakcynów sie zmniejsza. W medycynie nazywaja to starzeniem sie wakcynów. Zrobiono tymczasem wazne spostrzezenie, ze rozklad bakterji nie na¬ stepuje w obecnosci heksametylenotetrami- ny lub innych preparatów powyzszego cia¬ la, soli i zwiazków zespolonych, o ile roz¬ puszczaja sie w wodzie. Najlepiej poste¬ powac nalezy w ten sposób, ze bakterje splawia sie w rozczynie heksametylenote- traminy lub innego odpowiedniego zwiazku heksametylenotetraminowego. Tak otrzy¬ mane wakcyny nie ulegaja zadnym zmia¬ nom i sa, praktycznie mówiac, bezgranicz¬ nie trwale; zastosowanie podanych zwiaz¬ ków nietyiko jest korzystne z podanych wzgledó,w lecz takze powoduje znacznie silniejsze dzialanie wakcynów.Dla otrzymania np. trwalego wakcynu gonokokowego postepuje sie nastepujaco: 2—3 dni stara kulture gonokoków rozciera sie z taka iloscia 40%-ego rozczynu heksa- metylenotetraminy, ze splawiny zawieraja nastepnie w jednym kubicznym centyme¬ trze pozadano ilosc zawiazków np. 50 lub 100 mil jonów gonokoków. W splawinach tych gonokoki zamieraja wkrótce.Mozna takze uzyc jako materjal wyj¬ sciowy zabite gonokoki, przyczem nie jest •sie zwiazanym 40%-wym rozczynem hek¬ sametylenotetraminy, mozna bowiem sto¬ sowac takze rozczyny innego stopnia pro¬ centowego.Przy wytwarzaniu wakcynów z innych bakteryj postepowac nalezy podobnie. Hek- sametylenotetramine mozna, jak juz zazna¬ czono, zastapic innym zwiazkiem heksame- tylenotetraminowym np. solami lub jod¬ kami heksametylenotetraminowemi zwiaz¬ kami heksametylenotetraminy z amidem kwasu octowochlorowego lub jodowego i t. P. PLThe watery fluff of the bacterium, serving as vaccin, shows the disadvantage that the bacteria gradually decompose, thereby reducing the activity of the vaccinia. In medicine, they call it the aging of the vaccinia. Meanwhile, an important observation has been made that bacterial decomposition does not occur in the presence of hexamethylene tetramine or other preparations of the above body, salts and complexes, as long as they are soluble in water. Ideally, the bacteria are stained in a solution of hexamethylenetetramine or another suitable hexamethylenetetramine compound. The vaccinins thus obtained do not undergo any change and are, practically speaking, infinitely persistent; the use of the above-mentioned compounds is advantageous for the given reasons, but also causes a much stronger action of vaccinia. To obtain, for example, a stable gonococcal vaccin, proceed as follows: 2-3 days old gonococcal culture is grinded with 40% hexa - methylenetetramines, where the welds then contain in one cubic centimeter the number of buds, for example 50 or 100 million gonococcal ions. These gonococci will soon die in the foulings. Killed gonococci can also be used as a starting material, since this is not a 40% solution of hexamethylene tetramine, as it is also possible to use solutions of a different percentage. for other bacteria, the same should be followed. Hexamethylenetetramine can, as already noted, be replaced with another hexamethylenetetramine compound, for example with hexamethylenetetramine salts or iodides, hexamethylenetetramine compounds with acetic acid or iodine amide, etc.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2000B1 true PL2000B1 (en) | 1925-05-30 |
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